Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Susan V. Hughes"'
Autor:
Lisa M. Freeman, Ronjon Chakraverty, Katie N. Evans, Susan V. Hughes, Deborah Hardie, Terry K. Means, Martin Hewison
Publikováno v:
Blood. 106:2042-2049
Glucocorticoids (GCs) exert powerful anti-inflammatory effects that may relate in part to their ability to restrict the differentiation and function of dendritic cells (DCs). Although these inhibitory effects are dependent upon GCs binding to nuclear
Autor:
Susan V. Hughes, Martin Hewison, Rosemary Bland, Susan L.F. Chan, Paul E. Squires, Claire E. Hills, Danijela Markovic
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. :121-125
A number of studies have suggested that Vitamin D has a potential role in the development/treatment of diabetes. These effects may be mediated by circulating levels of 1alpha,25(OH)(2)D(3), but local production of 1alpha,25(OH)(2)D(3), catalysed by t
Autor:
Rosemary Bland, Lisa M. Freeman, Katie N. Evans, Aristides G. Eliopoulos, Ronjon Chakraverty, Susan V. Hughes, Paul Moss, Mark D. Kilby, Martin Hewison
Publikováno v:
The Journal of Immunology. 170:5382-5390
The functions of dendritic cells (DCs) are tightly regulated such that protective immune responses are elicited and unwanted immune responses are prevented. 1 alpha 25-dihydroxyvitamin D(3) (1 alpha 25(OH)(2)D(3)) has been identified as a major facto
Autor:
L.J. Eyre, Paul M. Stewart, Martin Hewison, Susan V. Hughes, Rosemary Bland, Mark S. Cooper, Michael C. Sheppard, Elizabeth H. Rabbitt
Publikováno v:
Journal of Cellular Biochemistry. 81:453-462
11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) acts as a pre-receptor signaling mechanism for corticosteroids by regulating the access of active glucocorticoids to both glucocorticoid (GR) and mineralocorticoid receptors (MR). To examine the rela
Autor:
Rosemary Bland, Paul M. Stewart, Susan V. Hughes, Daniel Zehnder, Martin Hewison, Pierre Ronco
Publikováno v:
Kidney international. 60(4)
Regulation of vitamin D-1α-hydroxylase in a human cortical collecting duct cell line. Background Recent studies have shown that renal expression of 25-hydroxyvitamin D 3 -1α-hydroxylase (1α-OHase) is not restricted to proximal tubules. To investig