Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Jan Tavernier"'
Leptin brain entry via a tanycytic LepR–EGFR shuttle controls lipid metabolism and pancreas function
Autor:
Emilie Caron, Rubén Nogueiras, Ulrich Boehm, Manon Duquenne, Markus Schwaninger, Jerome Clasadonte, Cyril Bourouh, Eleonora Deliglia, Stéphane Ory, Young-Bum Kim, Stéphane Gasman, Eric Trinquet, Soumya Kusumakshi, Asturo Oishi, Massimiliano Mazzone, S. Rasika, Daniela Fernandois, Nathalie Jouy, Jan Tavernier, Cintia Folgueira, Marion Millet, Anisia Silva, Julie Dam, Ines Martinez-Corral, Ralf Jockers, Monica Imbernon, Vincent Prevot, Jean-Sébastien Annicotte
Publikováno v:
Nature Metabolism
Nature Metabolism, Nature Publishing Group, 2021, 3 (8), pp.1071-1090. ⟨10.1038/s42255-021-00432-5⟩
Nature metabolism
Nature Metabolism, Nature Publishing Group, 2021, 3 (8), pp.1071-1090. ⟨10.1038/s42255-021-00432-5⟩
Nature metabolism
Metabolic health depends on the brain’s ability to control food intake and nutrient use versus storage, processes that require peripheral signals such as the adipocyte-derived hormone, leptin, to cross brain barriers and mobilize regulatory circuit
Autor:
Ralf Jockers, Jan Tavernier, Joris Wauman, Marine Luka, Julie Dam, Vincent Prevot, Tori Lhomme, Tangui Maurice, Lennart Zabeau, Erika Cecon, Anisia J. Silva, Min Min Chen
Publikováno v:
Neuroendocrinology
Neuroendocrinology, 2021, 111 (4), pp.370-387. ⟨10.1159/000508105⟩
Neuroendocrinology, 2021, 111 (4), pp.370-387. ⟨10.1159/000508105⟩
Introduction: Metabolic dysfunction is now recognized as a pivotal component of Alzheimer’s disease (AD), the most common dementia worldwide. However, the precise molecular mechanisms linking metabolic dysfunction to AD remain elusive. Objective: H
Autor:
Bart Vandekerckhove, Anje Cauwels, Gilles Uzé, An Goethals, Stijn De Munter, Nele Vanderroost, Alexander Van Parys, Frank Peelman, Jan Tavernier, Jennyfer Bultinck, Peter Brouckaert, Annick Verhee, Jeroen Hostens, Leander Huyghe, Sandra Van Lint, Niko Kley, Lennart Zabeau
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 2, Pp n/a-n/a (2020)
EMBO Molecular Medicine
EMBO Molecular Medicine, Wiley Open Access, 2019, ⟨10.15252/emmm.201911223⟩
EMBO MOLECULAR MEDICINE
EMBO Molecular Medicine
EMBO Molecular Medicine, Wiley Open Access, 2019, ⟨10.15252/emmm.201911223⟩
EMBO MOLECULAR MEDICINE
Systemic toxicities have severely limited the clinical application of tumor necrosis factor (TNF) as an anticancer agent. Activity‐on‐Target cytokines (AcTakines) are a novel class of immunocytokines with improved therapeutic index. A TNF‐based
Autor:
T.M. Wijesuriya, Jan Tavernier, Rachel Wevrick, Leentje De Ceuninck, Karin Vanessa Carias, Delphine Masschaele, Matthea R. Sanderson
Publikováno v:
Human Molecular Genetics. 26:4215-4230
In Prader-Willi syndrome (PWS), obesity is caused by the disruption of appetite-controlling pathways in the brain. Two PWS candidate genes encode MAGEL2 and necdin, related melanoma antigen proteins that assemble into ubiquitination complexes. Mice l
Autor:
Claude Libert, Marlies Ballegeer, Jan Tavernier, Ioanna Petta, Sam Lievens, Lien Dejager, Karolien De Bosscher
Publikováno v:
Microbiology and Molecular Biology Reviews. 80:495-522
SUMMARYGlucocorticoids (GCs) have been widely used for decades as a first-line treatment for inflammatory and autoimmune diseases. However, their use is often hampered by the onset of adverse effects or resistance. GCs mediate their effects via bindi
Autor:
Ralf Jockers, Lennart Zabeau, Elianne Burg, Jan Tavernier, Jennifer De Geest, Sandra Van Lint, Anisia Silva, Julie Dam, Joris Wauman, Elke Rogge
Publikováno v:
Cellular and molecular life sciences : CMLS. 76(6)
Leptin links body energy stores to high energy demanding processes like reproduction and immunity. Based on leptin's role in autoimmune diseases and cancer, several leptin and leptin receptor (LR) antagonists have been developed, but these intrinsica
Autor:
Jan Tavernier, Delphine De Sutter, Delphine Masschaele, Joris Wauman, Giel Vandemoortele, Leentje De Ceuninck, Sven Eyckerman
Publikováno v:
Journal of proteome research. 17(4)
Ring finger protein 41 (RNF41) is an E3 ubiquitin ligase involved in the ubiquitination and degradation of many proteins including ErbB3 receptors, BIRC6, and parkin. Next to this, RNF41 regulates the intracellular trafficking of certain JAK2-associa
Autor:
Jan Tavernier, Dorien Clarisse, Karlien Van Wesemael, Ilse M. Beck, Fritz Offner, Karolien De Bosscher
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 5, p e0197000 (2018)
PLOS ONE
PLoS ONE, Vol 13, Iss 5, p e0197000 (2018)
PLOS ONE
Glucocorticoids (GCs) are a cornerstone in the treatment of lymphoid malignancies such as multiple myeloma (MM) and acute lymphoblastic leukemia (ALL). Yet, prolonged GC use is hampered by deleterious GC-related side effects and the emergence of GC r
Autor:
Riet De Rycke, Kris Gevaert, Viacheslav Mylka, Lode De Cauwer, Claude Libert, Julie Deckers, Wim Vanden Berghe, Jan Tavernier, Francis Impens, Jonathan Thommis, Dariusz Ratman, Karolien De Bosscher
Publikováno v:
Autophagy
AUTOPHAGY
AUTOPHAGY
Glucocorticoids are widely used to treat inflammatory disorders; however, prolonged use of glucocorticoids results in side effects including osteoporosis, diabetes and obesity. Compound A (CpdA), identified as a selective NR3C1/glucocorticoid recepto
Autor:
Lode De Cauwer, Claude Libert, Sam Lievens, Jonathan Thommis, Nadia Bougarne, Jan Tavernier, Marlies Ballegeer, Sofie Desmet, Ioanna Petta, Lien Dejager, Sofie Vandevyver, Karolien De Bosscher, Jolien Vandewalle
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
SCIENTIFIC REPORTS
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
SCIENTIFIC REPORTS
The transcriptional activity of the glucocorticoid receptor (GR) is co-determined by its ability to recruit a vast and varying number of cofactors. We here identify Striatin-3 (STRN3) as a novel interaction partner of GR that interferes with GR’s l