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Autor:
Anna Carbone, Patrizia Diana, Silvia Tisi, Ignazio Castagliuolo, Libero Caracausi, Girolamo Cirrincione, Alessia Salvador, Francesco Dall'Acqua, Paola Barraja, Daniela Vedaldi, Alessandra Montalbano, Paola Brun
Publikováno v:
ChemMedChem. 6:1238-1248
Heteroanalogues of angelicin, pyrrolo[3,2-h]quinazolines, were synthesized with the aim of obtaining new potent photochemotherapeutic agents. Many derivatives caused a significant decrease in cell proliferation in several human tumor cell lines after
Autor:
Paola Barraja, Daniela Vedaldi, Paola Brun, Alessia Salvador, Anna Carbone, Virginia Spanò, Patrizia Diana, Barbara Parrino, Alessandra Montalbano, Girolamo Cirrincione
Publikováno v:
European journal of medicinal chemistry. 102
A new series of pyrazolo[3,4-h]quinolines, heteroanalogues of angelicin was conveniently prepared with a broad substitution pattern. A large number of derivatives was obtained and the cellular photocytotoxicity was evaluated in vitro against 5 differ
Autor:
Patrizia Diana, Anna Carbone, Virginia Spanò, Paola Barraja, Daniela Vedaldi, Alessandra Montalbano, Barbara Parrino, M Muscarella, Alessia Salvador, Girolamo Cirrincione
Derivatives of new ring systems 11H-pyrido[3',2':4,5]pyrrolo[3,2-c]cinnoline and pyrido[3',2':4,5]pyrrolo[1,2-c][1,2,3]benzotriazine have been prepared from the key intermediates 2-(1H-pyrrolo[2,3-b]pyridin-2-yl)anilines in excellent yields (94-99%)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46fb0014c8c524b05fb4acca58a96803
http://hdl.handle.net/10447/102794
http://hdl.handle.net/10447/102794
Autor:
Girolamo Cirrincione, Ignazio Castagliuolo, Alessia Salvador, Libero Caracausi, Giorgio Palù, Patrizia Diana, Paola Barraja, Daniela Vedaldi, Paola Brun, Francesco Dall'Acqua, Anna Carbone, Alessandra Montalbano
In the search for new photochemotherapeutic agents, a series of derivatives of the ring system pyrrolo[3,2-h]quinoline--bioisosters of the angular furocoumarin angelicin--were synthesized through a four-step synthetic approach, in reasonable overall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88da20c1b189b679b3f317089fdf0a14
http://hdl.handle.net/10447/51294
http://hdl.handle.net/10447/51294
Autor:
Alessia Salvador, Paola Barraja, Daniela Vedaldi, Gaetano Dattolo, Giampietro Viola, Alessandra Montalbano, Girolamo Cirrincione, Giuseppe Basso, Annamaria Martorana, Francesco Dall'Acqua, Patrizia Diana
Publikováno v:
Journal of medicinal chemistry. 51(8)
Isoindoloquinoxalines 4 and 5 were obtained by refluxing 2-(2'-aminoaryl)-1-cyanoisoindoles 3a- e in acetic or formic acid. All derivatives were screened by the National Cancer Institute (Bethesda, MD) for the in vitro one dose primary anticancer ass