Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Hanke L. Matlung"'
Autor:
Panagiota Bouti, Bart J. A. M. Klein, Paul J. H. Verkuijlen, Karin Schornagel, Floris P. J. van Alphen, Kees-Karel H. Taris, Maartje van den Biggelaar, Arie J. Hoogendijk, Robin van Bruggen, Taco W. Kuijpers, Hanke L. Matlung
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundThe importance of CD11b/CD18 expression in neutrophil effector functions is well known. Beyond KINDLIN3 and TALIN1, which are involved in the induction of the high-affinity binding CD11b/CD18 conformation, the signaling pathways that orches
Externí odkaz:
https://doaj.org/article/53bd94c6190c4bc09c41a6251de19372
Autor:
Angela A. F. Gankema, Charita Furumaya, Sara Fernández-Hermira, Mark Hoogenboezem, Hanke L. Matlung, Robin van Bruggen, Taco W. Kuijpers
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Cancer is one of the leading causes of death worldwide. Treatment outcome is largely dictated by the tumor type, disease stage, and treatment success rates, but also by the variation among patients in endogenous anti-tumor responses. Studies indicate
Externí odkaz:
https://doaj.org/article/a0094b75d97d41fcb931be4af775aa0c
Autor:
Paula Martinez-Sanz, Adrien R. G. Laurent, Edith Slot, Mark Hoogenboezem, Nikolina Bąbała, Robin van Bruggen, Anthony Rongvaux, Richard A. Flavell, Godelieve A. M. Tytgat, Katka Franke, Hanke L. Matlung, Taco W. Kuijpers, Derk Amsen, Julien J. Karrich
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionMISTRG mice have been genetically modified to allow development of a human myeloid compartment from engrafted human CD34+ haemopoietic stem cells, making them particularly suited to study the human innate immune system in vivo. Here, we c
Externí odkaz:
https://doaj.org/article/6f2a3ef6081c4018ae68e848da1ea48c
Autor:
Panagiota Bouti, Steven D. S. Webbers, Susanna C. Fagerholm, Ronen Alon, Markus Moser, Hanke L. Matlung, Taco W. Kuijpers
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Neutrophils are the most prevalent leukocytes in the human body. They have a pivotal role in the innate immune response against invading bacterial and fungal pathogens, while recent emerging evidence also demonstrates their role in cancer progression
Externí odkaz:
https://doaj.org/article/572fb513c6ea41069fe1f4be174f5cf2
Autor:
Annette E. Neele, Hung-Jen Chen, Marion J. J. Gijbels, Saskia van der Velden, Marten A. Hoeksema, Marieke C. S. Boshuizen, Jan Van den Bossche, Anton T. Tool, Hanke L. Matlung, Timo K. van den Berg, Esther Lutgens, Menno P. J. de Winther
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Macrophages define a key component of immune cells present in atherosclerotic lesions and are central regulators of the disease. Since epigenetic processes are important in controlling macrophage function, interfering with epigenetic pathways in macr
Externí odkaz:
https://doaj.org/article/a428a6da91984e6f8be4eb28adb8b03a
Autor:
Katka Franke, Saravanan Y. Pillai, Mark Hoogenboezem, Marion J. J. Gijbels, Hanke L. Matlung, Judy Geissler, Hugo Olsman, Chantal Pottgens, Patrick J. van Gorp, Maria Ozsvar-Kozma, Yasuyuki Saito, Takashi Matozaki, Taco W. Kuijpers, Rudi W. Hendriks, Georg Kraal, Christoph J. Binder, Menno P. J. de Winther, Timo K. van den Berg
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The inhibitory immunoreceptor SIRPα is expressed on myeloid and neuronal cells and interacts with the broadly expressed CD47. CD47-SIRPα interactions form an innate immune checkpoint and its targeting has shown promising results in cancer patients.
Externí odkaz:
https://doaj.org/article/ee6a819bfd8145e18c05d69a81a9717a
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Over the last decades, cancer immunotherapies such as checkpoint blockade and adoptive T cell transfer have been a game changer in many aspects and have improved the treatment for various malignancies considerably. Despite the clinical success of har
Externí odkaz:
https://doaj.org/article/21b5187689dd404593e540c93c0f7727
Autor:
Louise W. Treffers, Michel van Houdt, Christine W. Bruggeman, Marieke H. Heineke, Xi Wen Zhao, Joris van der Heijden, Sietse Q. Nagelkerke, Paul J. J. H. Verkuijlen, Judy Geissler, Suzanne Lissenberg-Thunnissen, Thomas Valerius, Matthias Peipp, Katka Franke, Robin van Bruggen, Taco W. Kuijpers, Marjolein van Egmond, Gestur Vidarsson, Hanke L. Matlung, Timo K. van den Berg
Publikováno v:
Frontiers in Immunology, Vol 9 (2019)
The function of the low-affinity IgG-receptor FcγRIIIb (CD16b), which is uniquely and abundantly expressed on human granulocytes, is not clear. Unlike the other Fcγ receptors (FcγR), it is a glycophosphatidyl inositol (GPI) -anchored molecule and
Externí odkaz:
https://doaj.org/article/4f7effa6b2a44b6cb973aba88e5a5277