Zobrazeno 1 - 10
of 19
pro vyhledávání: 'Lüllmann-Rauch, Renate'
Autor:
Renate Lüllmann-Rauch, M. Ziegenhagen
Publikováno v:
Histochemistry. 95:263-268
The purpose of the present investigation was to examine whether or not a di-cationic amphiphilic compound that is known (1) to be accumulated in lysosomes and (2) to form insoluble complexes with sulfated glycosaminoglycans (sGAG) in vitro, is able t
Publikováno v:
Archives of Toxicology. 64:291-298
The purpose of the present investigation was to establish a cell culture system suitable for demonstrating the drug-induced lysosomal storage of sulfated glycosaminoglycans (GAGs). This is a drug side-effect which was previously studied in animals tr
Publikováno v:
Toxicology and applied pharmacology. 114(2)
In the accompanying paper, four dibasic acridine derivatives were reported to induce lysosomal storage of sulfated glycosaminoglycans (sGAG), i.e., mucopolysaccharidosis, in cultured fibroblast (Handrock et al. Toxicol. Appl. Pharmacol. 114, 1992). T
Publikováno v:
Experimental and Molecular Pathology. 49:279-289
The dicationic amphiphilic compound tilorone was previously shown to interfere with the lysosomal degradation of sulfated glycosaminoglycans (GAGs) of cultured cells and to cause mucopolysaccharidosis-like alterations in several organs of rats. Since
Autor:
Renate Lüllmann-Rauch
Publikováno v:
Virchows Archiv B Cell Pathology Including Molecular Pathology. 44:355-368
This ultrastructural and histochemical study deals with the lysosomal storage phenomena occurring in the rat liver after repeated oral administration of tilorone, an agent with anti-tumor and anti-viral activities. In the sinusoidal endothelium and i
Autor:
Heinz Lüllmann, Renate Lüllmann-Rauch
Publikováno v:
Toxicology and Applied Pharmacology. 61:138-146
The antiestrogenic drug tamoxifen is an amphiphilic cationic compound and might therefore be suspected to interfere with intralysosomal catabolism of polar lipids as previously observed with several other amphiphilic cationic drugs. Large oral doses
Autor:
Renate Lüllmann-Rauch
Publikováno v:
Graefe's Archive for Clinical and Experimental Ophthalmology. 224:377-383
According to clinical reports, the antitumor drug tilorone induces corneal opacities in patients. The present communication shows that keratopathy can be experimentally reproduced in rats and describes the cellular alterations underlying the corneal
Autor:
Renate Lüllmann-Rauch
Publikováno v:
Histochemistry. 93:149-154
The cationic dyes Cuprolinic Blue (CB) and Toluidine Blue (TB) were used to preserve the intralysosomal storage material accumulating in tilorone-induced mucopolysaccharidosis. As shown in previous studies, the stored glycosaminoglycans (GAGs) are le
Publikováno v:
Virchows Archiv B Cell Pathology Including Molecular Pathology. 48:33-45
The purpose of this study was to examine whether the aortic and mitral valves of rats are involved in the mucopolysaccharidosis-like disorder induced by tilorone. Rats were treated with large doses of the drug for periods of 1–21 weeks. After chron
Publikováno v:
Toxicology. 44:45-59
The purpose of this study was to test whether or not the antiviral drug amantadine induces the structural features of lipidosis in intact animals (rats) and cultured cells, and to investigate the interactions between amantadine and phospholipids. Chl