Zobrazeno 1 - 10
of 15
pro vyhledávání: '"John R. Foster"'
Autor:
Sadhna Srivastava, S.D. Gangolli, Michael A. Collins, Colin R. Stubberfield, John R. Foster, Brian G. Lake
Publikováno v:
Acta Pharmacologica et Toxicologica. 51:217-226
The oral administration of 500–2500 mg/kg/day dicyclohexyl phthalate (DCHP) to young male Sprague-Dawley rats for 7 days resulted in liver enlargement and induction of some parameters of hepatic xenobiotic metabolism. Additional studies indicated t
Publikováno v:
Toxicology and Applied Pharmacology. 98:185-197
Cysteine conjugate beta-lyase (beta-lyase) was purified to electrophoretic homogeneity from the kidney cytosol of male Wistar rats. The highly purified enzyme exhibited a monomeric molecular weight of 50,000 Da and was active in the alpha-beta elimin
Publikováno v:
The Journal of Pathology. 139:309-321
Prepubertal rats treated orally with di-n-pentyl phthalate at 2.2 g/kg body weight were killed at 1, 3, 6 and 24 hr following a single dose, and after 2, 3 and 4 days of repeated daily dosing. At 3 hr Sertoli cells in a proportion of the seminiferous
Autor:
Lucy V. Thomas, Sharat D. Gangolli, John R. Foster, Dianne M. Creasy, Paul M. D. Foster, Melvyn W. Cook
Publikováno v:
Toxicology and Applied Pharmacology. 69:385-399
Ethylene glycol monomethyl (EGM) and monoethyl (EGE) ethers were administered po to rats at dosages varying from 50 to 500 mg/kg body weight/day for EGM and 250 to 1000 mg/kg body weight/day EGE for 11 days. First evidence of testicular damage follow
Publikováno v:
Clinical Immunology and Immunopathology. 30:62-70
Inbred rats fed diets containing 150 ppm dioctyltin dichloride (DOTC) demonstrated a progressive reduction in thymic weight. This was accompanied by a decrease in both the number of circulating lymphocytes and their ability to respond to mitogenic st
Publikováno v:
Toxicology and Applied Pharmacology. 72:46-60
Young male Sprague-Dawley rats and Syrian hamsters were treated with 25–1000 mg/kg/day di-(2-ethylhexyl) phthalate (DEHP) orally for 14 days. Liver enlargement was observed in both species, the magnitude being greater in the rat than in the hamster
Publikováno v:
Journal of Comparative Pathology. 101:421-427
Procarbazine hydrochloride, an antineoplastic drug, was administered to pregnant rats from days 13 to 16 of gestation at doses of 0, 1, 5 and 15 mg per kg as part of a behavioural study. Histological examination of the brains from the offspring at 12
Publikováno v:
Toxicology and Applied Pharmacology. 63:120-132
Di-n-pentyl phthalate has previously been shown in our laboratory to produce testicular atrophy in young male rats when administered orally at 2.2 g/kg body wt/day for 4 days. Development of testicular damage by this compound was also associated with
Autor:
Christopher F. Hayward, Jamie McQuade, Dorothea Sesardic, Edward A. Lock, John R. Foster, Clifford R. Elcombe, Donald S. Davies, Richard T. Robson, Alan R. Boobis
Publikováno v:
Biochemical Pharmacology. 35:4543-4554
The cellular distribution of cytochrome P-450 has been studied in the liver and a number of extrahepatic tissues in the rat by immunocytochemistry, using an antibody raised against cytochrome P-450 form c. Immunoreactive cytochrome P-450, most probab
Publikováno v:
Toxicology and applied pharmacology. 67(1)
Primary cultures of rat hepatocytes were exposed to a range of chemicals known to cause peroxisome proliferation in vivo. Peroxisomal palmitoyl-CoA oxidation and carnitine acetyltransferase (CAT) activity were increased within 12 to 24 hr of adding 0