Zobrazeno 1 - 10
of 58
pro vyhledávání: 'Lüllmann-Rauch, Renate'
Autor:
Hans Bockhardt, Renate Lüllmann-Rauch
Publikováno v:
Acta Pharmacologica et Toxicologica. 47:45-48
This study was aimed at the question of whether or not the antidepressant zimelidine, which is an amphiphilic cationic compound, can induce generalized lipidosis in animals. Rats were chronically treated with high oral doses (80 mg/kg) of the drug, a
Publikováno v:
Graefe's Archive for Clinical and Experimental Ophthalmology. 239:788-793
A series of dicationic amphiphilic drugs, most of them immunomodulatory agents, are known to induce generalised lysosomal storage of sulphated glycosaminoglycans (GAGs) in rats and in cultured cells of several species including man. The present study
Publikováno v:
General Pharmacology: The Vascular System. 27:1317-1324
1. Certain compounds (e.g., the immunomodulator tilorone and congeners) are able to induce lysosomal storage of sulphated glycosaminoglycans (GAG), thus, producing cytological and biochemical alterations reminiscent of the inherited mucopolysaccharid
Publikováno v:
Toxicology. 110:27-37
The antimalarial agents quinacrine and chloroquine are well known as potent inducers of lysosomal storage of polar lipids (lipidosis) in cell culture and in vivo. In previous experiments on cultured fibroblasts, chloroquine was shown to additionally
Autor:
Renate Lüllmann-Rauch, Stefan H. Geist
Publikováno v:
Annals of Anatomy - Anatomischer Anzeiger. 176:3-9
Summary The purpose of this study was to investigate the effects of two lipidosis-inducing drugs (the anorectic drug chlorphentermine and the tricyclic antidepressantimipramine) upon the estrous cycle of rats and upon the morphology of the vaginal an
Autor:
Renate Lüllmann-Rauch, M. Ziegenhagen
Publikováno v:
Histochemistry. 95:263-268
The purpose of the present investigation was to examine whether or not a di-cationic amphiphilic compound that is known (1) to be accumulated in lysosomes and (2) to form insoluble complexes with sulfated glycosaminoglycans (sGAG) in vitro, is able t
Publikováno v:
Archives of Toxicology. 64:291-298
The purpose of the present investigation was to establish a cell culture system suitable for demonstrating the drug-induced lysosomal storage of sulfated glycosaminoglycans (GAGs). This is a drug side-effect which was previously studied in animals tr
Autor:
Heinz Beck, Volkmar Gieselmann, Simon Ngamli Fewou, Matthias Eckhardt, Renate Lüllmann-Rauch, Julika Pitsch, Kerstin Khalaj Hedayati
Metachromatic leukodystrophy is a lysosomal storage disorder caused by deficiency in the sulfolipid degrading enzyme arylsulfatase A (ASA). In the absence of a functional ASA gene, 3-O-sulfogalactosylceramide (sulfatide; SGalCer) and other sulfolipid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db2e807382d88dcf3e84edc1a06b1afe
https://europepmc.org/articles/PMC6672212/
https://europepmc.org/articles/PMC6672212/
Publikováno v:
Toxicology. 85(2-3)
Some immunomodulatory drugs have previously been shown to induce lysosomal storage of sulfated glycosaminoglycans (sGAG) in intact organisms and cultured cells. These compounds consist of a planary aromatic ring system and two symmetric side chains e
Publikováno v:
Toxicology and applied pharmacology. 114(2)
The purpose of the present cytological and radiochemical study was to investigate whether the immunomodulatory agent 3,6-bis[2-(diethylamino)ethoxy]acridine (CL-90.100) and three congeners induce lysosomal storage of sulfated glycosaminoglycans (sGAG