Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Susan S. Margulies"'
Autor:
Michael F. Beers, Gladys G. Lawrence, Jason D. Christie, Jennifer Pogoriler, Edward E. Morrisey, Y. Suzuki, William J. Zacharias, Edward Cantu, David M. Chenoweth, Dolinay Tamas, Chanat Aonbangkhen, Alec M. Stablow, Susan S. Margulies
Publikováno v:
Respiratory Research, Vol 19, Iss 1, Pp 1-14 (2018)
Respiratory Research
Respiratory Research
Background Acute respiratory distress syndrome (ARDS) is a severe form of lung injury characterized by damage to the epithelial barrier with subsequent pulmonary edema and hypoxic respiratory failure. ARDS is a significant medical problem in intensiv
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237613 (2020)
PLoS ONE
PLoS ONE
Background Nordihydroguaiaretic acid (NDGA) is a plant extract that has been shown to act as a free radical scavenger and pluripotent inhibitor of pro-inflammatory cytokines, two major cellular processes involved in the pathophysiology of sepsis. We
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 57:193-203
Ventilator-induced lung injury (VILI) is a severe complication of mechanical ventilation that can lead to acute respiratory distress syndrome. VILI is characterized by damage to the epithelial barrier with subsequent pulmonary edema and profound hypo
Autor:
Dmitry A. Goncharov, Seung-Beom Hong, Melane L. James, Laura S. Schmidt, Masaya Baba, Andrew J. Gow, W. Marston Linehan, Hua Li, Susan H. Guttentag, Susan S. Margulies, Linda W. Gonzales, Vera P. Krymskaya, Elena A. Goncharova, Victoria Stepanova, Elena N. Atochina-Vasserman
Publikováno v:
Cell Reports, Vol 7, Iss 2, Pp 412-423 (2014)
Cell reports, vol 7, iss 2
Cell reports, vol 7, iss 2
Summary: Spontaneous pneumothoraces due to lung cyst rupture afflict patients with the rare disease Birt-Hogg-Dubé (BHD) syndrome, which is caused by mutations of the tumor suppressor gene folliculin (FLCN). The underlying mechanism of the lung mani
Autor:
Nurit Davidovich, Gladys G. Lawrence, Peter Chhour, Brian C. DiPaolo, Susan S. Margulies, Nadir Yehya
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:156-164
Mechanical ventilation with high tidal volumes has been associated with pulmonary alveolar flooding. Understanding the mechanisms underlying cyclic stretch-induced increases in alveolar epithelial permeability may be important in designing preventive
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 304:L210-L220
Simulating ventilator-induced lung injury (VILI) in the laboratory requires stretching of lung alveolar tissue. Whereas precision-cut lung slices (PCLSs) are widely used for studying paracrine signaling pathways in the lungs, their use in stretch stu
Autor:
Sunita Bhandare, Susan S. Margulies, Todd J. Kilbaugh, Manda Saraswati, David H. Lorom, Courtney L. Robertson
Publikováno v:
Journal of Neurotrauma. 28:763-774
Cyclosporin A (CsA) has been shown to be neuroprotective in mature animal models of traumatic brain injury (TBI), but its effects on immature animal models of TBI are unknown. In mature animal models, CsA inhibits the opening of the mitochondrial per
Publikováno v:
American Journal of Physiology-Cell Physiology. 299:C345-C353
Alveolar epithelial cells (AEC) maintain integrity of the blood-gas barrier with gasket-like intercellular tight junctions (TJ) that are anchored internally to the actin cytoskeleton. We hypothesize that stretch rapidly reorganizes actin (10 min) int
Publikováno v:
European Respiratory Journal. 32:854-861
The present study measured stretch-induced changes in transepithelial permeability to uncharged tracers (1.5-5.5 A) using cultured monolayers of alveolar epithelial type-I like cells. Cultured alveolar epithelial cells were subjected to uniform cycli
Autor:
Susan S. Margulies, Jacob L. Fisher
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 292:L40-L53
While a number of whole cell mechanical models have been proposed, few, if any, have focused on the relationship among plasma membrane tension, plasma membrane unfolding, and plasma membrane expansion and relaxation via lipid insertion. The goal of t