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Autor:
Doris Zane, Rachna Jain, Roshni Singh, Josephine Shelton, Bing Yang, Yan Wang, Shane Roller, Thomas R. Alessi, Melanie Felx, Paul L. Feldman
Publikováno v:
Microbiology Spectrum
Microbiology Spectrum, Vol 9, Iss 1 (2021)
Microbiology Spectrum, Vol 9, Iss 1 (2021)
The toxicity of tenofovir alafenamide (TAF) hemifumarate (HF) was evaluated when administered by continuous subcutaneous (s.c.) infusion via an external infusion pump for 28 days to rats and dogs. The toxicokinetics of TAF and two metabolites, tenofo
Autor:
Ziemann, Christian, Roller, Jonas, Malter, Markus M., Keller, Kira, Kollmar, Otto, Glanemann, Matthias, Menger, Michael D., Sperling, Jens
Publikováno v:
BMC Cancer
BMC Cancer, Vol 19, Iss 1, Pp 1-8 (2019)
BMC Cancer, Vol 19, Iss 1, Pp 1-8 (2019)
BACKGROUND: Intra-arterial therapy with embolics is established for the treatment of malignancies of the liver. However, there are no studies comparing the different effects of various embolics used in clinical practice. Herein, we analyzed the effec
Publikováno v:
Phytochemistry. 115:9-19
Carnosic acid (salvin), which possesses antioxidative and antimicrobial properties, is increasingly exploited within the food, nutritional health and cosmetics industries. Since its first extraction from a Salvia species (∼70years ago) and its iden
Publikováno v:
Oncology Reports. 32:1296-1302
Galium verum, also known as Lady's Bedstraw, is an herbaceous plant native to Europe and Asia, and has been used in traditional medicine as an anticancer medicine applied in most cases as a decoction. The influence of a Galium verum decoction on the
Autor:
Erin Swiger, Thomas J. Rimele, Vincent Rash, David Moncol, Donald L. Hertzog, Caroline J. Diaz, Jon L. Collins, Christopher Nystrom, Pierette Banker, David J. Cowan, Channa K Jayawickreme, Josephine Yuen, Sean Ross, Shane Roller, Xi Liang, Steven M. Sparks, Christopher Joseph Aquino, Dock Steven Thomas, Grace Chen
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(5)
The long chain free fatty acid receptor 4 (FFA4/GPR120) has recently been recognized as lipid sensor playing important roles in nutrient sensing and inflammation and thus holds potential as a therapeutic target for type 2 diabetes and metabolic syndr
Autor:
Roller, Markus1 (AUTHOR) markus.roller@bmr-online.de
Publikováno v:
Inhalation Toxicology. Jul2009 Supplement 1, Vol. 21, p144-157. 14p. 2 Diagrams, 6 Charts, 1 Graph.
Autor:
ROLLER, MARKUS1 (AUTHOR), POTT, FRIEDRICH2 (AUTHOR)
Publikováno v:
Annals of the New York Academy of Sciences. 2006, Vol. 1076 Issue 1, p266-280. 15p. 3 Diagrams, 2 Charts.
Autor:
Eric E. Boros, Robert L. Dobbins, Maggie S. McIntyre, Ryan Klein, David J. Cowan, Xi Liang, Xiaozhou Yao, Andrew A. Young, Kristin M. Patterson, Paul L. Feldman, John Ray, Christine L. Merrill, Lindsey T. Harston, Jeff L. Ambroso, Jon L. Collins, Shane Roller, Michael J. Bishop, Judith S. Prescott, Christopher Joseph Aquino, Alan Cunningham, Don L. Anderson, Istvan Kaldor, Wu Yulin, Lihong Chen, Josephine Yuen
Publikováno v:
Journal of Medicinal Chemistry. 56:5094-5114
The apical sodium-dependent bile acid transporter (ASBT) transports bile salts from the lumen of the gastrointestinal (GI) tract to the liver via the portal vein. Multiple pharmaceutical companies have exploited the physiological link between ASBT an
Autor:
Marc Roller, Juan Carlos Espín, María Romo Vaquero, Francisco A. Tomás-Barberán, María-Teresa García-Conesa, Emilie Fromentin, John G. Flanagan, Rocío García Villalba, Mar Larrosa, María J. Yáñez-Gascón
Publikováno v:
Molecular Nutrition & Food Research. 57:1834-1846
Scope: Carnosic acid (CA) and derived diterpenes abundant in rosemary extracts (REs) exert anti-obesity effects. The aim of this study was to investigate the bioavailability of these compounds in a rat model of obesity. Methods and results: A total o