Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Mahadevan Rajasekaran"'
Publikováno v:
Urology. 69:791-794
OBJECTIVES The molecular mechanisms by which potassium induces urinary bladder hyperactivity are not clear. In the present study, we tested our hypothesis that potassium chloride (KCl)-induced bladder hyperactivity might be mediated through a calcium
Autor:
Paul C. Stein, Marianne Chenoweth, Amir H. Arsanjani, C. Lowell Parsons, Mahadevan Rajasekaran
Publikováno v:
Urology. 69:577-581
Tamm-Horsfall protein (THP) from normal urine has been shown to protect against the cytotoxic effects of toxic urinary cations (TFs) in vivo and in vitro. This study investigated the effect of desialylation on the cytoprotective activity of THP.From
Publikováno v:
BJU International. 98:430-434
OBJECTIVE To evaluate the effects of MN-001, a novel orally active anti-inflammatory agent, in suppressing the bladder hyperactivity resulting from ovalbumin (OA)-induced mast-cell stimulation in a rat model. MATERIALS AND METHODS Sprague-Dawley rats
Publikováno v:
International Journal of Impotence Research. 16:187-194
To evaluate the association between hypertension, male erectile function, Rho-kinase, and cyclic GMP pathways, we monitored neurogenic erectile response in spontaneously hypertensive (SHR) vs normotensive rats. We also evaluated SHR erectile function
Publikováno v:
BJU international. 104(2)
OBJECTIVES To evaluate whether rat fetal brain stem cells can be induced to acquire cell fates outside the nervous system, hypothesising that cell-based replacement therapy with stem cells can aid in the regeneration of penile smooth musculature and
Publikováno v:
The journal of sexual medicine. 5(6)
Animal models have contributed, to a great extent, to our understanding and advancement in the field of sexual medicine. Many current medical and surgical therapies in sexual medicine are the direct result of the development of such animal models. Ov
Publikováno v:
International journal of urology : official journal of the Japanese Urological Association. 13(4)
Loss of the lower urinary permeability barrier and passive potassium cycling into tissue are an initiating event in interstitial cystitis. We tested whether a low molecular weight cytotoxic fraction from normal urine causes sensitivity to intravesica
Publikováno v:
Neurourology and urodynamics. 24(3)
Spontaneously hypertensive rats (SHR) exhibit overactive bladder (OAB) symptoms and have an up-regulated calcium sensitizing RhoA/Rho-kinase pathway in their vascular smooth muscle tissues. This study examined the role of RhoA/Rho-kinase pathway in b
Publikováno v:
Urology. 66(4)
To test whether the presence of Tamm-Horsfall protein (THP) can limit the injury caused by low-molecular-weight (LMW) urinary cations using an in vivo rat bladder injury model. Previous studies have shown that normal urine contains LMW cations toxic
Publikováno v:
Journal of andrology. 26(2)
Physiological aging is a significant risk factor in the on-set of male erectile dysfunction (ED) and an imbalance in factors that modulate cavernosal smooth-muscle tone may play a role in these altered penile hemodynamic mechanisms. To evaluate the a