Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kevin Chipman"'
Autor:
Stuart Harrad, Jinkang Zhang, Maciej Bromirski, J. Kevin Chipman, Gopal Pawar, Mark R. Viant, Mohamed Abou-Elwafa Abdallah, Kyle D’Silva
Publikováno v:
Analytical and Bioanalytical Chemistry. 407:1871-1883
The high resolution, accurate mass, and fast scanning features of the Orbitrap(TM) mass spectrometer, combined with the separation power of ultrahigh-performance liquid chromatography were applied for the first time to study the metabolic profiles of
peer-reviewed Biochar production, from pyrolysis of lignocellulosic feedstocks, agricultural residues, and animal and poultry manures are emerging globally as novel industrial and commercial products. It is important to develop and to validate a seri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5658535d0a5293a80d8171fa8a1ef924
Publikováno v:
Environmental Science & Technology. 48:2732-2740
α-, β-, and γ-Hexabromocyclododecanes (HBCDs) were subjected to in vitro biotransformation experiments with rat and trout liver S9 fractions for different incubation times (10, 30, and 60 min) at 2 concentration levels (1 and 10 μM). The metaboli
Autor:
Leda Mirbahai, Angela Mally, Kevin Hickling, Carolin Hamberger, Tim D. Williams, Tao Chen, J. Kevin Chipman
Publikováno v:
Toxicology. 292:63-70
Furan, a widely used industrial compound, has been found in a number of heated food items. Furan is carcinogenic to rats and mice, but the mechanism behind its carcinogenic effect is still not well understood. In this study, we tested the hypothesis
Autor:
Nil Turan, Wolfgang Dekant, Francesco Falciani, Philipp Antczak, Angela Mally, Sabrina Moro, J. Kevin Chipman
Publikováno v:
Toxicological Sciences. 126:336-352
Furan, a heat-generated food contaminant, is hepatotoxic and carcinogenic in rodents. Furan is oxidized by cytochrome P450 2E1 to cis-2-butene-1,4-dial, a chemically reactive α,β-unsaturated dialdehyde, which has been identified as the key toxic me
Publikováno v:
Environmental Health Perspectives
Background Evidence of potent rodent carcinogenicity via an unclear mechanism suggests that furan in various foods [leading to an intake of up to 3.5 μg/kg body weight (bw)/day] may present a potential risk to human health. Objectives We tested the
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1628:22-29
Connexin32 (Cx32) is the predominant gap junction protein expressed in adult rat hepatocytes. This study investigated transcriptional regulation of the rat Cx32 gene in MH 1 C 1 rat hepatoma cells using transient expression assays in conjunction with
Publikováno v:
Toxicology. 187:101-115
Chemical carcinogens are generally classified as genotoxic or non-genotoxic. However, weak genotoxicity at high concentrations is sometimes observed and interpretation is often problematic. In addition, certain rodent carcinogens exert their effects
Publikováno v:
General Pharmacology: The Vascular System. 26:1445-1453
1. Hepatocyte couplets can be routinely prepared from rat liver to produce a suitable in vitro model for polarized primary cells. 2. Centrifugal elutriation provides a means of producing enriched subpopulations of periportal and perivenous couplets f
Publikováno v:
Biochemical Pharmacology. 47:625-632
Isolated rat hepatocyte couplets were used to study the effects of menadione and a rise in the intracellular concentration of calcium on biliary canalicular function. Canalicular function was assessed by counting the percentage of couplets which were