Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Kazuhiko Nozaki"'
Autor:
Kampei Shimizu, Satoshi Shimo, Mieko Oka, Tomohiro Aoki, Kazuhiko Nozaki, Isao Ono, Nobuhiko Ohno, Hirokazu Koseki, Hirohiko Imai, Mika Kushamae, Haruka Miyata, Takakazu Kawamata, Yu Abekura, Akitsugu Kawashima
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Smooth muscle cells (SMCs) are the major type of cells constituting arterial walls and play a role to maintain stiffness via producing extracellular matrix. Here, the loss and degenerative changes of SMCs become the major histopathological features o
Autor:
Tomohiro Aoki, Susumu Miyamoto, Kazuhiko Nozaki, Mieko Oka, Mika Kushamae, Hiroharu Kataoka, Yu Abekura, Tohru Mizutani, Kampei Shimizu, Haruka Miyata, Takakazu Kawamata
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 78:798-807
Subarachnoid hemorrhage due to rupture of intracranial aneurysms is a life-threatening disease. Although some previous reports have demonstrated an association between lipid accumulation and degenerative changes in aneurysmal walls in humans, epidemi
Autor:
Haruka Miyata, Kazuhiko Nozaki, Yu Abekura, Hirokazu Koseki, Tomohiro Aoki, Shuh Narumiya, Hiroharu Kataoka, Susumu Miyamoto, Kampei Shimizu
Publikováno v:
Neurologia medico-chirurgica
Subarachnoid hemorrhage due to rupture of a pre-existing intracranial aneurysm has quite a poor outcome in spite of intensive medical care. Hemodynamic stress loaded on intracranial arterial walls is considered as a trigger and a regulator of formati
Autor:
Isao Ono, Haruka Miyata, Tomohiro Aoki, Hirokazu Koseki, Kampei Shimizu, Yu Abekura, Manabu Shirai, Tohru Mizutani, Mika Kushamae, Kazuhiko Nozaki, Mieko Oka
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Subarachnoid hemorrhage due to rupture of an intracranial aneurysm has a quite poor prognosis after the onset of symptoms, despite the modern technical advances. Thus, the mechanisms underlying the rupture of lesions should be clarified. To this end,
Autor:
Juhana Frȍsen, Eliisa Ollikainen, Tomohiro Aoki, Shuh Narumiya, Miyuki Fukuda, Johanna P. Laakkonen, Keiichi Tsuji, Kana Bando, Kazuhiko Nozaki, Go Shioi
Intracranial aneurysms are common but are generally untreated, and their rupture can lead to subarachnoid hemorrhage. Because of the poor prognosis associated with subarachnoid hemorrhage, preventing the progression of intracranial aneurysms is criti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1bb2ec116ffcfcf0e61da15b0bcff4f
http://hdl.handle.net/10138/233572
http://hdl.handle.net/10138/233572
Autor:
Tomohiro Aoki, Haruka Miyata, Hirokazu Koseki, Kazuhiko Nozaki, Shuh Narumiya, Katsumi Takizawa, Hidetoshi Kasuya
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175421 (2017)
PLoS ONE
PLoS ONE
Given the social importance of intracranial aneurysm as a major cause of a lethal subarachnoid hemorrhage, clarification of mechanisms underlying the pathogenesis of this disease is essential for improving poor prognosis once after rupture. Previous
Autor:
Kazuhiko Nozaki, Kenzo Tsunetoshi, Hirotoshi Imamura, Yasushi Takagi, Kent Doi, Tsuyoshi Ohta, Ken-ichiro Kikuta
Publikováno v:
Atherosclerosis. 211:114-121
Objective The aim of this study was to investigate the transdifferentiation of bone marrow (BM)-derived endothelial progenitor cells (EPCs) into the smooth muscle cell (SMC) lineage in vitro and in vivo . Methods and results EPCs were obtained from B
Autor:
R Morishita, Tomohiro Aoki, Hiroharu Kataoka, Kazuhiko Nozaki, Nobuo Hashimoto, Ryota Ishibashi
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 29:1080-1086
Background— Reduced extracellular matrix is a prominent feature of cerebral aneurysms (CAs). We previously reported excessive ECM degradation in CA walls. In the present study, we examined collagen biosynthesis in CA walls and the molecular mechani
Autor:
Makoto Hayase, Nobuo Hashimoto, Shohei Wakao, Yutaka Itokazu, Mari Dezawa, Yasushi Takagi, Kazuhiko Nozaki, Masaaki Kitada
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 29:1409-1420
Bone marrow stromal cells (MSCs) are an excellent source of cells for treating a variety of central nervous system diseases. In this study, we report the efficient induction of committed neural progenitor cells from rat and human MSCs (NS-MSCs) by in
Autor:
Kensuke Egashira, Hiroharu Kataoka, Kazuhiko Nozaki, Tomohiro Aoki, Ryota Ishibashi, Nobuo Hashimoto
Publikováno v:
Stroke. 40:942-951
Background and Purpose—Recent studies have suggested that chronic inflammation actively participates in cerebral aneurysm (CA) formation. Macrophages accumulate in CA walls and express proinflammatory genes promoting CA progression, but the molecul