Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Joanne A. Harrold"'
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 32:428-436
The ability of clozapine to induce weight gain in female rats was investigated in three studies with progressively lowered doses of clozapine. In an initial preliminary high dose study, clozapine at 6 and 12 mg/kg (i.p., b.i.d.) was found to induce w
Autor:
Andrew J. Goudie, John P.H. Wilding, Joanne A. Harrold, Gillian D. Cooper, Jason C.G. Halford, Lucy Pickavance
Publikováno v:
Journal of Psychopharmacology. 21:405-413
Many of olanzapine's (OLZ) actions in humans related to weight regulation can be modelled in female rats (Cooper et al., 2005). Such effects include weight gain, hyperphagia, enhanced visceral adiposity and elevated Levels of insulin and adiponectin.
Autor:
Joanne A. Harrold, Gareth Williams
Publikováno v:
Peptides. 27:365-371
This paper reviews aspects of our research, focusing on the role of the melanocortin system in the central regulation of feeding and energy balance, which was begun in 1997. It describes data from successive physiological studies, concerning the iden
Autor:
Joanne A. Harrold, Peter Brodin, Peter King, Mona Byström, Gareth Williams, Kerstin Lindgren, Kerstin Enquist, Joanne C. Elliott, Assar Bäckman
Publikováno v:
Molecular Brain Research. 128:150-159
Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide that stimulates feeding and increases body weight in rodents. We studied the role of the system in energy homeostasis and its regulation by the satiety signals, leptin and insulin. We
Autor:
Joanne A. Harrold, Gareth Williams
Publikováno v:
British Journal of Nutrition. 90:729-734
Knowledge of the cannabinoid system and its components has expanded greatly over the past decade. There is increasing evidence for its role in the regulation of food intake and appetite. Cannabinoid system activity in the hypothalamus is thought to c
Publikováno v:
Peptides. 24:397-405
alpha-Melanocyte stimulating hormone (MSH) has generally been assumed to be the endogenous ligand acting at the melanocortin-4 receptor (MC4-R), activation of which in the hypothalamus leads to reduced feeding. However, beta-MSH is also capable of ac
Publikováno v:
Proceedings of the Nutrition Society. 59:385-396
The hypothalamus is the focus of many peripheral signals and neural pathways that control energy homeostasis and body weight. Emphasis has moved away from anatomical concepts of ‘feeding’ and ‘satiety’ centres to the specific neurotransmitter
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 279:E340-E347
We investigated the relative importance of overeating, thermogenesis, and uncoupling protein (UCP) expression in determining the severity of obesity in male Wistar rats fed a highly palatable diet. After 2 wk of feeding, body weight did not differ si
Publikováno v:
Brain Research. 847:90-97
5-Hydroxytryptamine (5-HT, serotonin), synthesized in midbrain raphe nuclei and released in various hypothalamic sites, decreases food intake but the specific 5-HT receptor subtypes involved are controversial. Here, we have studied changes in the reg
Autor:
John C. Clapham, Mohammad Tadayyon, XJ Cai, Joanne A. Harrold, Robin E. Buckingham, Shelagh Wilson, Peter S. Widdowson, John P.H. Wilding, Gareth R. Williams, Jonathan R.S. Arch
Publikováno v:
Diabetes. 48:2132-2137
Orexins (hypocretins), novel peptides expressed in specific neurons of the lateral hypothalamic area (LHA), stimulate feeding when injected intracerebroventricularly. We investigated their role in feeding in the rat by measuring hypothalamic prepro-o