Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Chang, Z"'
Autor:
Jarvis, Michael F., Burgard, Edward C., McGaraughty, Steve, Honore, Prisca, Lynch, Kevin, Brennan, Timothy J., Subieta, Alberto, van Biesen, Tim, Cartmell, Jayne, Bianchi, Bruce, Niforatos, Wende, Kage, Karen, Yu, Haixia, Mikusa, Joe, Wismer, Carol T., Zhu, Chang Z., Chu, Katharine, Lee, Chih-Hung, Stewart, Andrew O., Polakowski, James, Cox, Bryan F., Kowaluk, Elizabeth, Williams, Michael, Sullivan, James, Faltynek, Connie
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2002 Dec . 99(26), 17179-17184.
Externí odkaz:
https://www.jstor.org/stable/3074083
Autor:
Arthur L. Nikkel, Ji Ma, L. Olson, Sujatha M. Gopalakrishnan, Kelly J. Doyle, Vivek C. Abraham, D. L. Widomski, Steve McGaraughty, Brent Putman, Murali Gopalakrishnan, Laura Leys, Chang Z. Zhu, Steve D. Pratt, Zhi Su, Chih-Hung Lee, K. Salte
Publikováno v:
European Journal of Pharmacology. 788:1-11
Adenosine (ADO) is an important regulatory purine nucleoside that accumulates at sites of inflammation and tissue injury including in diseases associated with renal pathology. Endogenous levels of ADO may be increased by inhibiting the ADO-metabolizi
Autor:
Diana L. Donnelly-Roberts, Arthur L. Nikkel, Chang Z. Zhu, Steve McGaraughty, Kelly J. Doyle, Murali Gopalakrishnan, Marian T. Namovic, K. Salte, Lauren Olsen, D. L. Widomski, Zhi Su
Publikováno v:
Journal of pharmacological and toxicological methods. 94(Pt 1)
Introduction The adenine model of kidney disease typically involves dietary delivery of adenine over several weeks. This model can be variable in its disease progression and can result in significant mortality. In the current study, the amount of ade
Autor:
Timothy A. Vortherms, Michael F. Jarvis, Chang Z. Zhu, Daria Darczak, Jill M. Wetter, Victoria E. Scott, Chih-Hung Lee, Shashank Shekhar, Clinton M. Yeung, Michael R. Schrimpf, Patricia N. Banfor, Ivan Milicic, Kennan C. Marsh, Andrew M. Swensen, Loan N. Miller, Xenia Beebe
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:4857-4861
A novel series of N-type calcium channel inhibitors have been discovered. Optimization of potency and HT-ADME properties provides 4-aminocyclopentapyrrolidines with analgesic efficacy after oral dosing.
Akademický článek
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Autor:
Torben R. Neelands, Andrew O. Stewart, Gricelda H. Simler, Chengmin Zhong, Andrew J. King, Chang Z. Zhu, George Doherty, Andrew M. Swensen, Ivan Milicic, Janel M. Boyce-Rustay, Cenchen Zhan, Patricia N. Banfor, Timothy A. Vortherms, Victoria E. Scott, Natalie Bratcher, Michael F. Jarvis, Wende Niforatos, Helmut Mack, Pramila Bhatia
Publikováno v:
Biochemical Pharmacology. 83:406-418
Blockade of voltage-gated Ca²⁺ channels on sensory nerves attenuates neurotransmitter release and membrane hyperexcitability associated with chronic pain states. Identification of small molecule Ca²⁺ channel blockers that produce significant an
Autor:
Chih-Hung Lee, Ann Tovcimak, Michael W. Decker, Gerard B. Fox, Gricelda H. Simler, Prisca Honore, Jordan W. Brown, Chang Z. Zhu, Madhavi Pai, Nathan R. Rustay, Chih-Liang Chin, Chengmin Zhong, Joe Mikusa, Murali Gopalakrishnan, Victoria A. Komater, Donna M. Gauvin, Anita K. Salyers, Scott J. Baker, La Geisha Lewis, Peer B. Jacobson, Erica Gomez, Prasant Chandran
Publikováno v:
Biochemical Pharmacology. 82:967-976
Positive modulation of the neuronal nicotinic acetylcholine receptor (nAChR) α4β2 subtype by selective positive allosteric modulator NS-9283 has shown to potentiate the nAChR agonist ABT-594-induced anti-allodynic activity in preclinical neuropathi
Autor:
Arthur A. Hancock, Jill M. Wetter, Kennan C. Marsh, Prisca Honore, Gin C. Hsieh, Anita K. Salyers, Prasant Chandran, Timothy A. Esbenshade, Marlon D. Cowart, Joe Mikusa, Jorge D. Brioni, Erica J. Wensink, Madhavi Pai, Thomas R. Miller, Scott J. Baker, Chang Z. Zhu, David G. Witte
Publikováno v:
Pharmacology Biochemistry and Behavior. 95:41-50
The histamine H(4) receptor (H(4)R) is expressed primarily on cells involved in inflammation and immune responses. To determine the potential role of H(4)R in pain transmission, the effects of JNJ7777120, a potent and selective H(4) antagonist, were
Autor:
Vincent P. Hradil, Ann Tovcimak, Anita K. Salyers, Keith B. Ryther, Betty B. Yao, Prisca Honore, Tiffany Runyan Garrison, Bradley A. Hooker, Odile F. El Kouhen, Anthony V. Daza, Gin C. Hsieh, Yihong Fan, Erica J. Wensink, Michael Meyer, Megan E. Gallagher, Gerard B. Fox, Michael J. Dart, Chang Z. Zhu, Madhavi Pai, Chih-Liang Chin, Prasant Chandran, George K. Grayson, Chengmin Zhong
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 328:141-151
Studies demonstrating the antihyperalgesic and antiallodynic effects of cannabinoid CB(2) receptor activation have been largely derived from the use of receptor-selective ligands. Here, we report the identification of A-836339 [2,2,3,3-tetramethyl-cy
Autor:
Matthew S Johnson, Dong Liu, Robert J. Gregg, Irene Drizin, Michael F. Gross, Gricelda Hernandez, Kennan C. Marsh, James B. Thomas, Mark L. Chapman, Chang Z. Zhu, Brian E. Marron, Connie R. Faltynek, Shailen K. Joshi, Prisca Honore, Stephen Werness, Michael E. Kort, Douglas S. Krafte, Robert N. Atkinson, Rosemarie Roeloffs, William A. Carroll, Marc J. C. Scanio, Xu-Feng Zhang, Donna M. Gauvin, Michael J. Krambis, Michael F. Jarvis, Char-Chang Shieh, Lei Shi, Joseph P. Mikusa
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:6379-6386
The synthesis and pharmacological characterization of a novel furan-based class of voltage-gated sodium channel blockers is reported. Compounds were evaluated for their ability to block the tetrodotoxin-resistant sodium channel Na(v)1.8 (PN3) as well