Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Anna Mae Diehl"'
Autor:
Franklin G. Berger, Balaraman Kalyanaraman, Anna Mae Diehl, Varun Chandrashekaran, Jacek Ziolenka, Diptadip Dattaroy, Firas Alhasson, James A. Carson, Ratanesh Seth, Saurabh Chatterjee
Publikováno v:
Redox Biology, Vol 13, Iss C, Pp 8-19 (2017)
Redox Biology
Redox Biology
Recent clinical studies found a strong association of colonic inflammation and Inflammatory bowel disease (IBD)-like phenotype with NonAlcoholic Fatty liver Disease (NAFLD) yet the mechanisms remain unknown. The present study identifies high mobility
Autor:
Thiago A. Pereira, Isaac S. Chan, Márcia Maria de Souza, Wing-Kin Syn, Vivian Resende, Steve S. Choi, Alba Otoni, Mariana Verdelho Machado, Anna Mae Diehl, Guilherme Vaz de Melo Trindade, Paula Vieira Teixeira Vidigal, Elisângela Trindade Santos, Izabela Voieta, William Evan Secor, Rafal P. Witek, Zilton A. Andrade, José Roberto Lambertucci, Guanhua Xie, Fausto Edmundo Lima Pereira
Publikováno v:
Clinical Science (London, England : 1979)
Schistosomal egg antigens induce host bile ductular cells to proliferate and produce osteopontin (OPN), a pro-fibrogenic factor that stimulates hepatic stellate cells to become myofibroblasts. The numbers of OPN-producing bile ductules correlate with
Autor:
Steve S. Choi, Jeongeun Hyun, Marzena Swiderska-Syn, Richard T. Premont, Youngmi Jung, Anna Mae Diehl, Bahar Salimian Rizi, George D. Dalton, Kuo Du, Gregory A. Michelotti, Eric Thelen
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Cirrhosis results from accumulation of myofibroblasts derived from quiescent hepatic stellate cells (Q-HSCs); it regresses when myofibroblastic HSCs are depleted. Hedgehog signaling promotes transdifferentiation of HSCs by activatin
Autor:
Anna Mae Diehl, Gregory A. Michelotti, Cynthia D. Guy, Thiago A. Pereira, Mariana Verdelho Machado, Ann Marie Zavacki, Dawn Piercy, Leandi Krüger, Manal F. Abdelmalek, Brittany N. Bohinc, Herbert Pang, Guanhua Xie, Marzena Swiderska-Syn, Ayako Suzuki
Publikováno v:
Endocrinology
Thyroid hormone (TH) is important for tissue repair because it regulates cellular differentiation. Intrahepatic TH activity is controlled by both serum TH levels and hepatic deiodinases. TH substrate (T4) is converted into active hormone (T3) by deio
Autor:
S Gautsch, Steve S. Choi, Dieter O. Fürst, Anna Mae Diehl, Michaela Granzow, Ganesh Ranabhat, Robert Schierwagen, Jonel Trebicka, Christian P. Strassburg, Frank Erhard Uschner, Esther Raskopf, Sabine Klein, Peter F.M. van der Ven, Tilman Sauerbruch
Publikováno v:
Scientific Reports
Liver cirrhosis but also portal vein obstruction cause portal hypertension (PHT) and angiogenesis. This study investigated the differences of angiogenesis in cirrhotic and non-cirrhotic PHT with special emphasis on the canonical (Shh/Gli) and non-can
Autor:
Heather Francis, Kathleen B. Schwarz, Steve S. Choi, Robert A. Anders, Cynthia D. Guy, Lee M. Bass, Shannon J. McCall, Alessia Omenetti, Peter F. Whitington, Gianfranco Alpini, Anna Mae Diehl, Maria Grazia Clemente
Publikováno v:
Hepatology. 53:1246-1258
Biliary atresia (BA) is notable for marked ductular reaction and rapid development of fibrosis. Activation of the Hedgehog (Hh) pathway promotes the expansion of populations of immature epithelial cells that coexpress mesenchymal markers and may be p
Autor:
Wing-Kin Syn, Alessia Omenetti, Rafal P. Witek, Youngmi Jung, Steve S. Choi, Gregory A. Michelotti, Anna Mae Diehl, Kolade M. Agboola, Cynthia A. Moylan, Gamze Karaca
Publikováno v:
Journal of Biological Chemistry. 285:36551-36560
Trans-differentiation of quiescent hepatic stellate cells (Q-HSCs), which exhibit epithelial and adipocytic features, into myofibroblastic-HSC (MF-HSCs) is a key event in liver fibrosis. Culture models demonstrated that Hedgehog (Hh) pathway activati
Autor:
Xiu-Rong Ren, Youngmi Jung, Alessia Omenetti, Vanessa Teaberry, Cynthia A. Moylan, Liu Yang, Anna Mae Diehl, Rafal P. Witek, Steve S. Choi, Jiangbo Wang, Thiago A. Pereira, Wing-Kin Syn, Gamze Karaca
Publikováno v:
Hepatology. 52:278-290
Chronic liver injury induces regenerative responses in the liver, including the activation of quiescent hepatic stellate cells (Q-HSC) to an activated, myofibroblastic phenotype that promotes scar formation and liver dysfunction.(1) Hepatic accumulat
Autor:
Youngmi Jung, Debra L. Sudan, Marcos Rojkind, Anna Mae Diehl, Liu Yang, Cynthia A. Moylan, Wing-Kin Syn, Jason K. Sicklick, Rafal P. Witek, Steve S. Choi, Alessia Omenetti, Gregory A. Michelotti
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 297:G1093-G1106
Myofibroblastic hepatic stellate cells (MF-HSC) are derived from quiescent hepatic stellate cells (Q-HSC). Q-HSC express certain epithelial cell markers and have been reported to form junctional complexes similar to epithelial cells. We have shown th
Autor:
Liu Yang, Anna Mae Diehl, Alessia Omenetti, Wing-Kin Syn, Alessandro Porrello, M. Eric Gershwin, Heather Francis, Steve S. Choi, Youngmi Jung, Rafal P. Witek, Marlyn J. Mayo, Gianfranco Alpini
Publikováno v:
Hepatology. 50:518-527
The mechanisms mediating hepatic accumulation of inflammatory cells in cholestatic liver disease remain enigmatic. Our thesis is that Hedgehog (Hh) pathway activation promotes hepatic accumulation of immune cells that interact with cholangiocytes. We