Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Susan S. Margulies"'
Autor:
Michael F. Beers, Gladys G. Lawrence, Jason D. Christie, Jennifer Pogoriler, Edward E. Morrisey, Y. Suzuki, William J. Zacharias, Edward Cantu, David M. Chenoweth, Dolinay Tamas, Chanat Aonbangkhen, Alec M. Stablow, Susan S. Margulies
Publikováno v:
Respiratory Research, Vol 19, Iss 1, Pp 1-14 (2018)
Respiratory Research
Respiratory Research
Background Acute respiratory distress syndrome (ARDS) is a severe form of lung injury characterized by damage to the epithelial barrier with subsequent pulmonary edema and hypoxic respiratory failure. ARDS is a significant medical problem in intensiv
Autor:
Dmitry A. Goncharov, Seung-Beom Hong, Melane L. James, Laura S. Schmidt, Masaya Baba, Andrew J. Gow, W. Marston Linehan, Hua Li, Susan H. Guttentag, Susan S. Margulies, Linda W. Gonzales, Vera P. Krymskaya, Elena A. Goncharova, Victoria Stepanova, Elena N. Atochina-Vasserman
Publikováno v:
Cell Reports, Vol 7, Iss 2, Pp 412-423 (2014)
Cell reports, vol 7, iss 2
Cell reports, vol 7, iss 2
Summary: Spontaneous pneumothoraces due to lung cyst rupture afflict patients with the rare disease Birt-Hogg-Dubé (BHD) syndrome, which is caused by mutations of the tumor suppressor gene folliculin (FLCN). The underlying mechanism of the lung mani
Publikováno v:
American Journal of Physiology-Cell Physiology. 299:C345-C353
Alveolar epithelial cells (AEC) maintain integrity of the blood-gas barrier with gasket-like intercellular tight junctions (TJ) that are anchored internally to the actin cytoskeleton. We hypothesize that stretch rapidly reorganizes actin (10 min) int
Publikováno v:
European Respiratory Journal. 32:854-861
The present study measured stretch-induced changes in transepithelial permeability to uncharged tracers (1.5-5.5 A) using cultured monolayers of alveolar epithelial type-I like cells. Cultured alveolar epithelial cells were subjected to uniform cycli
Autor:
Susan S. Margulies, Jacob L. Fisher
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 283:L737-L746
Na+-K+-ATPase pumps (Na+ pumps) in the alveolar epithelium create a transepithelial Na+ gradient crucial to keeping fluid from the pulmonary air space. We hypothesized that alveolar epithelial stretch stimulates Na+ pump trafficking to the basolatera
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 25:584-591
Previous studies have demonstrated that high tidal volumes can cause interstitial and alveolar edema, with degradation of pulmonary epithelial barrier integrity. Separate studies have shown that F-actin disruption and decreased intracellular ATP (ATP
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 305(2)
Alveolar epithelial cells (AECs) maintain the pulmonary blood-gas barrier integrity with gasketlike intercellular tight junctions (TJ) that are anchored internally to the actin cytoskeleton. We have previously shown that AEC monolayers stretched cycl
Autor:
Christian E. Overgaard, Susan S. Margulies, Michael Koval, Leslie A. Mitchell, Christina Ward
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 301(1)
Alveolar barrier function depends critically on the claudin family tight junction proteins. Of the major claudins expressed by alveolar epithelial cells, claudin (Cldn)-3 and Cldn-4 are the most closely related by amino acid homology, yet they differ
Publikováno v:
American journal of physiology. Cell physiology. 290(4)
We measured stretch-induced changes in transepithelial permeability in vitro to uncharged tracers 1.5–5.5 Å in radius to identify a critical stretch threshold associated with failure of the alveolar epithelial transport barrier. Cultured alveolar