Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Qingzhen Yu"'
Autor:
Yiding Zhang, Zhen Chen, Ran Cheng, Tuo Shao, Yihan Shao, Qingzhen Yu, Jun-An Ma, Kuan Hu, Xiaoyun Deng, Akiko Hatori, Steven H. Liang, Lee Josephson, Hualong Fu, Kenneth Dahl, Neil Vasdev, Michael A. Schafroth, Masayuki Fujinaga, Lin Xie, Christopher J. Fowler, Shuyin Gu, Thomas Lee Collier, Lu Wang, Benjamin F. Cravatt, Jian Rong, Daisuke Ogasawara, Tomoteru Yamasaki, Bao Liang, Yuancheng Gou, Ming-Rong Zhang, Xiaofei Zhang, Katsushi Kumata, Genwei Zhang, Wakana Mori, Jingjin Chen
Publikováno v:
Journal of Medicinal Chemistry. 62:3336-3353
Monoacylglycerol lipase (MAGL) is a serine hydrolase that degrades 2-arachidonoylglycerol (2-AG) in the endocannabinoid system (eCB). Selective inhibition of MAGL has emerged as a potential therapeutic approach for the treatment of diverse pathologic
Autor:
Tuo Shao, Genwei Zhang, Stephen F. Traynelis, Lee Josephson, Wei Han, Steven H. Liang, Vasily Belov, Jian Rong, Xiaoyun Deng, Hongjie Yuan, Weiting Tang, Pilar Giffenig, Mikhail Papisov, James B. Daunais, April T. Davenport, Qingzhen Yu, Zhen Chen, Scott J. Myers, Yihan Shao, Xiaofei Zhang, Zijing Li, Hualong Fu, Lu Wang
Publikováno v:
ACS Chem Neurosci
GluN2B is the most studied subunit of N-methyl-D-aspartate receptors (NMDARs) and implicated in the pathologies of various central nervous system disorders and neurodegenerative diseases. As pan NMDAR antagonists often produce debilitating side effec
Autor:
Xiaofei, Zhang, Yiding, Zhang, Zhen, Chen, Tuo, Shao, Richard, Van, Katsushi, Kumata, Xiaoyun, Deng, Hualong, Fu, Tomoteru, Yamasaki, Jian, Rong, Kuan, Hu, Akiko, Hatori, Lin, Xie, Qingzhen, Yu, Weijian, Ye, Hao, Xu, Douglas J, Sheffler, Nicholas D P, Cosford, Yihan, Shao, Pingping, Tang, Lu, Wang, Ming-Rong, Zhang, Steven H, Liang
Publikováno v:
Theranostics
Selective modulation of metabotropic glutamate receptor 2 (mGlu2) represents a novel therapeutic approach for treating brain disorders, including schizophrenia, depression, Parkinson's disease (PD), Alzheimer's disease (AD), drug abuse and addiction.
Autor:
Qingzhen, Yu, Katsushi, Kumata, Hua, Li, Yiding, Zhang, Zhen, Chen, Xiaofei, Zhang, Tuo, Shao, Akiko, Hatori, Tomoteru, Yamasaki, Lin, Xie, Kuan, Hu, Gangqiang, Wang, Lee, Josephson, Shaofa, Sun, Ming-Rong, Zhang, Steven H, Liang
Publikováno v:
Bioorg Med Chem Lett
Transmembrane AMPA receptor regulatory proteins (TARPs) are a recently discovered family of proteins that modulate AMPA receptors activity. Based on a potent and selective TARP subtype γ−8 antagonist, 6-(methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)b
Autor:
Hsiao-Ying Wey, Jian Rong, April T. Davenport, James B. Daunais, Zhen Chen, Steven H. Liang, Tuo Shao, Yihan Shao, Qingzhen Yu, Xiaoyun Deng, Lee Josephson, Hualong Fu, Wen‐Wei Qiu, Wei Gao, Thomas Lee Collier, Xiaofei Zhang
Publikováno v:
ChemMedChem
Leucin-rich repeat kinase 2 (LRRK2) is a large protein that is involved in the pathogenesis of Parkinson’s disease (PD). It has been demonstrated that LRRK2 mutations mainly confers PD, which bring about increased kinase activity of LRRK2. As a con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582b12669d0f0c0b9515b5f58da6b66e
https://europepmc.org/articles/PMC6726558/
https://europepmc.org/articles/PMC6726558/
Autor:
Irina A. Pikuleva, Tuo Shao, Zhen Chen, Qingzhen Yu, Yihan Shao, Jiahui Chen, Xiaoyun Deng, Hualong Fu, Steven H. Liang, Jiyun Sun, Natalia Mast, Thomas Lee Collier, Lee Josephson, Jian Rong
Publikováno v:
Bioorg Med Chem Lett
Cholesterol 24-hydroxylase is a monooxygenase encoded by CYP46A1, which is specifically expressed in the brain where it controls cholesterol elimination by producing 24S-hydroxylcholesterol (24-HC) as the major metabolite. Selective blockade of CYP46