Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Megumi Aimoto"'
Autor:
Megumi Aimoto, Akira Takahara, Mihoko Hagiwara-Nagasawa, Satoshi Kawakami, Kensuke Omura, Yoshinobu Nagasawa
Publikováno v:
Journal of Pharmacological Sciences, Vol 144, Iss 3, Pp 123-128 (2020)
We assessed the torsadogenic effects of a novel remyelinating drug clemastine for multiple sclerosis using an in vivo proarrhythmia model of acute atrioventricular block rabbit, since the drug has been demonstrated to suppress the human ether-a-go-go
Publikováno v:
Journal of Pharmacological Sciences, Vol 141, Iss 4, Pp 153-159 (2019)
Experimental evidence regarding the risk of proarrhythmic potential of acehytisine is limited. We assessed its electropharmacological effect together with proarrhythmic potential at intravenous doses of 4 and 10 mg/kg (n = 6) using isoflurane-anesthe
Publikováno v:
Biologicalpharmaceutical bulletin. 44(11)
Torsadogenic effects of ivabradine, an inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, were assessed in an in vivo proarrhythmia model of acute atrioventricular block rabbit. Ivabradine at 0.01, 0.1, and 1 mg/kg was i
Publikováno v:
Biologicalpharmaceutical bulletin. 44(8)
Aldosterone induces cardiac electrical and structural remodeling, which leads to the development of heart failure and/or atrial fibrillation (AF). However, it remains unknown whether aldosterone-induced remodeling may modulate the efficacy of anti-AF
Autor:
Kaori Sakai, Megumi Aimoto, Yoshinobu Nagasawa, Akira Takahara, Satoshi Kawakami, Rui Kurimoto
Publikováno v:
Journal of Pharmacological Sciences, Vol 143, Iss 1, Pp 39-44 (2020)
We investigated effects of isoflurane and sevoflurane on sparfloxacin-induced QT-interval prolongation in guinea pigs under the monitoring of electrocardiogram and monophasic action potential (MAP), which was compared with those of halothane or non-i
Autor:
Yoshinobu Nagasawa, Akira Takahara, Megumi Aimoto, Ryuichi Kambayashi, Kazuhiro Takada, Seiji Shibuta, Misako Nakajo, Mihoko Hagiwara
Publikováno v:
British Journal of Pharmacology. 174:2591-2605
Background and purpose Several rabbit proarrhythmia models have been recently developed by genetic or pharmacological methods to suppress the slow component of delayed rectifier K+ currents in the ventricle, leading to reduction of the repolarization
Autor:
Kensuke Omura, Naoki Omuro, Kaori Fujiwara, Kengo Kimura, Akira Takahara, Go Minemoto, Haruka Matsuzaki, Megumi Aimoto, K. Kobayashi, Satoshi Kawakami, Misa Oshiba, Yuichi Kenmotsu, Miki Shimizu, Yoshinobu Nagasawa
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 94:3-P2
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 93:3
Publikováno v:
Journal of Pharmacological Sciences, Vol 132, Iss 1, Pp 48-54 (2016)
We assessed electrophysiological effects of an atypical antipsychotic drug paliperidone in acute atrioventricular block rabbits. Intravenous administration of paliperidone at a clinically relevant dose (0.06 mg/kg) hardly affected the QT interval or