Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Michael Meyer-Hermann"'
Autor:
Rodrigo García-Valiente, Elena Merino Tejero, Maria Stratigopoulou, Daria Balashova, Aldo Jongejan, Danial Lashgari, Aurélien Pélissier, Tom G. Caniels, Mathieu A. F. Claireaux, Anne Musters, Marit J. van Gils, María Rodríguez Martínez, Niek de Vries, Michael Meyer-Hermann, Jeroen E. J. Guikema, Huub Hoefsloot, Antoine H. C. van Kampen
Publikováno v:
npj Systems Biology and Applications, Vol 9, Iss 1, Pp 1-14 (2023)
Abstract Sequencing of B-cell and T-cell immune receptor repertoires helps us to understand the adaptive immune response, although it only provides information about the clonotypes (lineages) and their frequencies and not about, for example, their af
Externí odkaz:
https://doaj.org/article/44b6c99bb69541cc9cb23059ccbecc30
Autor:
Danial Lashgari, Elena Merino Tejero, Michael Meyer-Hermann, Mathieu A F Claireaux, Marit J van Gils, Huub C J Hoefsloot, Antoine H C van Kampen
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 6, p e1010168 (2022)
Affinity maturation is an evolutionary process by which the affinity of antibodies (Abs) against specific antigens (Ags) increases through rounds of B-cell proliferation, somatic hypermutation, and positive selection in germinal centres (GC). The pos
Externí odkaz:
https://doaj.org/article/70672d97fb054db9b22c405c149345c9
Autor:
Wadim Koslow, Martin J Kühn, Sebastian Binder, Margrit Klitz, Daniel Abele, Achim Basermann, Michael Meyer-Hermann
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 5, p e1010054 (2022)
We analyze the relaxation of non-pharmaceutical interventions (NPIs) under an increasing number of vaccinations in Germany. For the spread of SARS-CoV-2 we employ a SIR-type model that accounts for age-dependence and includes realistic contact patter
Externí odkaz:
https://doaj.org/article/ac58cf7e54644d0da100d85d8beaaf2f
Autor:
Michael Meyer-Hermann
Publikováno v:
Cell Reports, Vol 36, Iss 8, Pp 109552- (2021)
Summary: The selection of B cells (BCs) in germinal centers (GCs) is pivotal to the generation of high-affinity antibodies and memory BCs, but it lacks global understanding. Based on the idea of a single Tfh-cell signal that controls BC selection and
Externí odkaz:
https://doaj.org/article/469bd26b71974c9d918ecf485d0bf875
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 12, p e1008428 (2020)
In vivo imaging of cytotoxic T lymphocyte (CTL) killing activity revealed that infected cells have a higher observed probability of dying after multiple contacts with CTLs. We developed a three-dimensional agent-based model to discriminate different
Externí odkaz:
https://doaj.org/article/88dbb07c6df34d56a2265b76a3f5d014
Autor:
Dorothea Reimer, Michael Meyer-Hermann, Asylkhan Rakhymzhan, Tobit Steinmetz, Philipp Tripal, Jana Thomas, Martin Boettcher, Dimitrios Mougiakakos, Sebastian R. Schulz, Sophia Urbanczyk, Anja E. Hauser, Raluca A. Niesner, Dirk Mielenz
Publikováno v:
Cell Reports, Vol 32, Iss 6, Pp 108030- (2020)
Summary: Plasma cells secreting affinity-matured antibodies develop in germinal centers (GCs), where B cells migrate persistently and directionally over defined periods of time. How modes of GC B cell migration influence plasma cell development remai
Externí odkaz:
https://doaj.org/article/1b38f80a110a4861a41f6604627db27e
Autor:
Sebastian J Theobald, Christoph Kreer, Sahamoddin Khailaie, Agnes Bonifacius, Britta Eiz-Vesper, Constanca Figueiredo, Michael Mach, Marija Backovic, Matthias Ballmaier, Johannes Koenig, Henning Olbrich, Andreas Schneider, Valery Volk, Simon Danisch, Lutz Gieselmann, Meryem Seda Ercanoglu, Martin Messerle, Constantin von Kaisenberg, Torsten Witte, Frank Klawonn, Michael Meyer-Hermann, Florian Klein, Renata Stripecke
Publikováno v:
PLoS Pathogens, Vol 16, Iss 7, p e1008560 (2020)
Human cytomegalovirus (HCMV) causes serious complications to immune compromised hosts. Dendritic cells (iDCgB) expressing granulocyte-macrophage colony-stimulating factor, interferon-alpha and HCMV-gB were developed to promote de novo antiviral adapt
Externí odkaz:
https://doaj.org/article/c1d9d22801744c638a64acbe75f4086c
Autor:
Nadine S Schaadt, Ralf Schönmeyer, Germain Forestier, Nicolas Brieu, Peter Braubach, Katharina Nekolla, Michael Meyer-Hermann, Friedrich Feuerhake
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 2, p e1007385 (2020)
Our aim is to complement observer-dependent approaches of immune cell evaluation in microscopy images with reproducible measures for spatial composition of lymphocytic infiltrates. Analyzing such patterns of inflammation is becoming increasingly impo
Externí odkaz:
https://doaj.org/article/f3da8b72c7e947d9b0fbceaeeebb7623
Autor:
Michael Meyer-Hermann
Publikováno v:
Cell Reports, Vol 29, Iss 5, Pp 1066-1073.e5 (2019)
Summary: Broadly neutralizing antibodies are crucial for the control of many life-threatening viral infections like HIV, influenza, or hepatitis. Their induction is a prime goal in vaccine research. Using computer simulations, we identify strategies
Externí odkaz:
https://doaj.org/article/efd201cefb1f46adbc15c4954ee4fa4f
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 18, p 6473 (2020)
Immunological synapse (IS) formation is a key event during antigen recognition by T cells. Recent experimental evidence suggests that the affinity between T cell receptors (TCRs) and antigen is actively modulated during the early steps of TCR signali
Externí odkaz:
https://doaj.org/article/21c2f21b530044ecaebc61a7d428bf05