Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Conor J. Kearney"'
Autor:
Tirta M. Djajawi, Lizzy Pijpers, Akash Srivaths, David Chisanga, Kok Fei Chan, Simon J. Hogg, Liam Neil, Sarahi Mendoza Rivera, Nenad Bartonicek, Sarah L. Ellis, Terry C.C. Lim Kam Sian, Pouya Faridi, Yang Liao, Bhupinder Pal, Andreas Behren, Wei Shi, Stephin J. Vervoort, Ricky W. Johnstone, Conor J. Kearney
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113831- (2024)
Summary: Cancer immunotherapies have demonstrated remarkable success; however, the majority of patients do not respond or develop resistance. Here, we conduct epigenetic gene-targeted CRISPR-Cas9 screens to identify epigenomic factors that limit CD8+
Externí odkaz:
https://doaj.org/article/f34b9312d8234fce939c7254165dac3d
Autor:
Imran G. House, Emily B. Derrick, Kevin Sek, Amanda X.Y. Chen, Jasmine Li, Junyun Lai, Kirsten L. Todd, Isabelle Munoz, Jessica Michie, Cheok Weng Chan, Yu-Kuan Huang, Jack D. Chan, Emma V. Petley, Junming Tong, DatMinh Nguyen, Sven Engel, Peter Savas, Simon J. Hogg, Stephin J. Vervoort, Conor J. Kearney, Marian L. Burr, Enid Y.N. Lam, Omer Gilan, Sammy Bedoui, Ricky W. Johnstone, Mark A. Dawson, Sherene Loi, Phillip K. Darcy, Paul A. Beavis
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113793- (2024)
Externí odkaz:
https://doaj.org/article/3bc9e9ff1e6348e1add4deb56de520ff
Autor:
Imran G. House, Emily B. Derrick, Kevin Sek, Amanda X.Y. Chen, Jasmine Li, Junyun Lai, Kirsten L. Todd, Isabelle Munoz, Jessica Michie, Cheok Weng Chan, Yu-Kuan Huang, Jack D. Chan, Emma V. Petley, Junming Tong, DatMinh Nguyen, Sven Engel, Peter Savas, Simon J. Hogg, Stephin J. Vervoort, Conor J. Kearney, Marian L. Burr, Enid Y.N. Lam, Omer Gilan, Sammy Bedoui, Ricky W. Johnstone, Mark A. Dawson, Sherene Loi, Phillip K. Darcy, Paul A. Beavis
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 113014- (2023)
Summary: CXCL9 expression is a strong predictor of response to immune checkpoint blockade therapy. Accordingly, we sought to develop therapeutic strategies to enhance the expression of CXCL9 and augment antitumor immunity. To perform whole-genome CRI
Externí odkaz:
https://doaj.org/article/36f8c10bf54b436e8b3737f736a4464b
Autor:
Andrew J. Freeman, Stephin J. Vervoort, Kelly M. Ramsbottom, Madison J. Kelly, Jessica Michie, Lizzy Pijpers, Ricky W. Johnstone, Conor J. Kearney, Jane Oliaro
Publikováno v:
Cell Reports, Vol 28, Iss 11, Pp 2784-2794.e5 (2019)
Summary: Despite the clinical success of cancer immunotherapies, the majority of patients fail to respond or develop resistance through disruption of pathways that promote neo-antigen presentation on MHC I molecules. Here, we conducted a series of un
Externí odkaz:
https://doaj.org/article/099c8c10b0f84d1e805bd39d02fcff16
Autor:
Rebecca Feltham, Kunzah Jamal, Tencho Tenev, Gianmaria Liccardi, Isabel Jaco, Celia Monteiro Domingues, Otto Morris, Sidonie Wicky John, Alessandro Annibaldi, Marcella Widya, Conor J. Kearney, Danielle Clancy, Paul R. Elliott, Timo Glatter, Qi Qiao, Andrew J. Thompson, Alexey Nesvizhskii, Alexander Schmidt, David Komander, Hao Wu, Seamus Martin, Pascal Meier
Publikováno v:
Cell Reports, Vol 23, Iss 2, Pp 470-484 (2018)
Summary: Tumor necrosis factor (TNF) is an inflammatory cytokine that can signal cell survival or cell death. The mechanisms that switch between these distinct outcomes remain poorly defined. Here, we show that the E3 ubiquitin ligase Mind Bomb-2 (MI
Externí odkaz:
https://doaj.org/article/fc7892f65de842ac9dd037eab1a8ff41
Publikováno v:
Cell Reports, Vol 11, Iss 10, Pp 1535-1548 (2015)
The NLRP3 inflammasome is involved in caspase-1-dependent maturation of IL-1β in many contexts. A two-signal model has emerged for IL-1β maturation, with LPS providing “signal I” and diverse agents such as ATP, Nigericin, streptolysin O, uric a
Externí odkaz:
https://doaj.org/article/e5e0a8b11f5141f7bb64529a0f5a3077