Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Daniel S. Marsman"'
Publikováno v:
Carcinogenesis. 16:77-82
Transforming growth factor alpha (TGF alpha) is a mitogenic growth factor for hepatocytes that may play a role in the development of liver cancer in rodents and humans. Epidermal growth factor receptor (EGFR) is the receptor for TGF alpha; its expres
Autor:
Daniel S. Marsman, James A. Popp
Publikováno v:
Carcinogenesis. 15:111-117
The biological potential of hepatic foci and tumors induced by peroxisome proliferators such as Wy-14,643 has been poorly characterized. In this study, male F-344 rats (n = 20/group/time point) were fed Wy-14,643 (0.1%) for 22, 37 or 52 weeks ('W-22'
Autor:
Blair U. Bradford, Ronald G. Thurman, Heidi K. Bojes, Barbara J. Keller, Daniel S. Marsman, James A. Popp, Russell C. Cattley
Publikováno v:
Toxicology and Applied Pharmacology. 119:52-58
Wy-14,643 is a potent nongenotoxic hepatic carcinogen and peroxisome proliferator in rodents; however, the mechanism by which it causes tumors remains unknown. In previous work it was demonstrated that Wy-14,643 caused a dose-dependent uncoupling of
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1102:237-244
A number of plasticizers and lipid-lowering drugs induce peroxisomes and cause hepatocellular carcinoma in rodents by mechanisms which remain unknown. In this study, seven structurally dissimilar peroxisome proliferating agents were shown to uncouple
Publikováno v:
Carcinogenesis. 13(6)
Earlier studies indicated that the hepatocarcinogenic activity of two peroxisome proliferators (PP) Wy-14,643 and di(2-ethylhexyl)phthalate (DEHP) correlated to the degree of lipofuscin accumulation and sustained cell replication rather than the leve
Publikováno v:
Carcinogenesis. 12(3)
The carcinogenicity of the peroxisome proliferator WY-14,643 was compared in young (starting age 2 months) and old (starting age 15 months) rats. Old rats had a 5- to 7-fold higher yield of grossly visible hepatic tumors following 22 weeks of dietary
Autor:
James A. Popp, Daniel S. Marsman, Konrad E. Tomaszewski, Russell C. Cattley, Michael J. Olson, James G. Conway
Publikováno v:
Carcinogenesis. 10:513-519
Quantitative comparisons of the time course of biochemical and morphological changes induced by peroxisome proliferators resulting in low and high incidences of hepatic cancer have not been conducted previously under bioassay conditions. [4-Chloro-6-
Publikováno v:
Toxicology. 56:1-7
The ability of the peroxisome proliferator WY-14,643 to act as an initiator of hepatocarcinogenesis was examined using a modified growth-selection protocol in rats. Feeding rats 0.1% WY-14,643 in the diet for 3 weeks, coupled with partial hepatectomy