Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Emma S. Jones"'
Autor:
Mark P. Del Borgo, Yan Wang, Pia Elizabeth Walters, Patrick Perlmutter, Marie-Isabel Aguilar, Iresha Spizzo, Lucinda M Hilliard, Robert E Widdop, Emma S Jones, Kate M. Denton, Morimer Khan, Sanja Bosnyak
Publikováno v:
Clinical Science. 129:505-513
We have previously shown that individual β-amino acid substitution in angiotensin (Ang) II reduced Ang II type 1 receptor (AT1R) but not Ang II type 2 receptor (AT2R)-binding and that the heptapeptide Ang III exhibited greater AT2R:AT1R selectivity
Autor:
Emma S Jones, Robert E Widdop, Kate M. Denton, U. Muscha Steckelings, Thomas Unger, Lucinda M Hilliard
Publikováno v:
Hilliard, L M, Jones, E S, Steckelings, U M, Unger, T, Widdop, R E & Denton, K M 2012, ' Sex-specific influence of angiotensin type 2 receptor stimulation on renal function : a novel therapeutic target for hypertension ', Hypertension, vol. 59, no. 2, pp. 409-414 . https://doi.org/10.1161/HYPERTENSIONAHA.111.184986
The renin-angiotensin system is a powerful regulator of arterial pressure and body fluid volume. Increasing evidence suggests that the angiotensin type 2 receptor (AT 2 R), which mediates the vasodilatory and natriuretic actions of angiotensin peptid
Autor:
Sanja Bosnyak, Emma S Jones, Marie-Isabel Aguilar, Arthur Christopoulos, Robert E Widdop, Walter G. Thomas
Publikováno v:
Clinical Science. 121:297-303
AT1R (angiotensin type 1 receptor) and AT2R (angiotensin type 2 receptor) are well known to be involved in the complex cardiovascular actions of AngII (angiotensin II). However, shorter peptide fragments of AngII are thought to have biological activi
Autor:
Walter G. Thomas, Robert E Widdop, Daniel Clayton, Emma S Jones, Nicholas Hausler, Julian Kirsch, Iresha Welungoda, Patrick Perlmutter, Sharon Unabia, Marie-Isabel Aguilar, Mark P. Del Borgo, Sanja Bosnyak
Publikováno v:
Hypertension. 57:570-576
Novel AT 2 R ligands were designed by substituting individual β-amino acid in the sequence of the native ligand angiotensin II (Ang II). Relative ATR selectivity and functional vascular assays (in vitro AT 2 R-mediated vasorelaxation and in vivo vas
Autor:
Ross A. D. Bathgate, Tim D. Hewitson, Mohsin Sarwar, Robert E Widdop, Martina Kocan, Bryna Sm Chow, Emma S Jones, Roger J. Summers, Belinda Wigg, Sanja Bosnyak, Chrishan S. Samuel
Publikováno v:
Kidney international
Fibrosis is a hallmark of chronic kidney disease, for which there is currently no effective cure. The hormone relaxin is emerging as an effective antifibrotic therapy; however, its mechanism of action is poorly understood. Recent studies have shown t
Publikováno v:
Journal of molecular and cellular cardiology. 37(5)
Ang II acting at AT(1)Rs has well documented effects on cardiovascular structure such as the promotion of cardiovascular hypertrophy and fibrosis, effects which are believed to be opposed by AT(2)R stimulation. AT(1) and AT(2)R expression are up regu