Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Madeleine Ennis"'
Publikováno v:
Kelly, C, Williams, M, Elborn, S, Ennis, M & Schock, B 2012, ' EXPRESSION OF THE INFLAMMATORY REGULATOR A20 CORRELATES WITH LUNG FUNCTION IN PATIENTS WITH CYSTIC FIBROSIS ' Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society .
Background: A20 and TAX1BP1 interact to negatively regulate NF--driven inflammation. A20 expression is altered in F508del/F508delpatients. Here we explore the effect of CFTR and CFTR genotype on A20 andTAX1BP1expression. The relationship with lung fu
Publikováno v:
European Respiratory Journal. 41:1058-1067
We hypothesised that primary bronchial epithelial cells (PBECs) from subjects with chronic obstructive pulmonary disease (COPD) respond differently to Pseudomonas aeruginosa lipopolysaccharide (LPS) after cigarette smoke extract (CSE) exposure than P
Publikováno v:
Pediatric Pulmonology. 43:202-462
Chronic lung disease associated with persistent infection and inflammation is the cause of death of most CF patients. The airways contain excess neutrophils as well as increased levels of pro-inflammatory cytokines. Bronchial epithelial cells play a
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 293:L69-L76
Proliferation of bronchial epithelial cells is an important biological process in physiological conditions and various lung diseases. The objective of this study was to determine how bronchial fibroblasts influence bronchial epithelial cell prolifera
Publikováno v:
Downey, D G, Brockbank, S, Martin, L, Ennis, M & Elborn, J 2007, ' The effect of treatment of cystic fibrosis pulmonary exacerbations on airways and systemic inflammation ' Pediatric Pulmonology, vol 42, no. 8, pp. 729-735 . DOI: 10.1002/ppul.20646
Background: Chronic infection in cystic fibrosis (CF) and airway inflammation leads to progressive lung injury Neutrophils are considered to be responsible for the onset and promotion of the inflammatory response within the CF lung. The relationship
Publikováno v:
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 15(4)
The effects of cigarette smoke extract (CSE) on airway epithelial cells (AECs) from cystic fibrosis (CF) and non-cystic fibrosis (non-CF) individuals are not fully understood. It has been suggested that CSE modulates inflammatory cytokine release fro
Autor:
Stuart Elborn, Charles G. Gallagher, Clare O'Connor, Barry J. Plant, Julia Courtney, Jackie Rendall, Kevin Morgan, Noor Kalsheker, Madeleine Ennis
Publikováno v:
Pediatric Pulmonology. 41:584-591
Modifier genes other than CFTR are thought to influence lung disease phenotype in cystic fibrosis (CF). In this study, we investigated the relationship between a polymorphism (1237 G A) in the 3′ enhancer region of the alpha-1-antitrypsin (AAT) gen
Autor:
Madeleine Ennis, Vanessa Brown
Publikováno v:
Current Respiratory Medicine Reviews. 1:1-6
A recent asthma audit demonstrated that, 1.4 million children (one in eight) in the UK today are receiving treatment for their asthma, and that this figure has increased six-fold in the last 25 years. The chronicity of asthma has been associated with
Autor:
Madeleine Ennis
Publikováno v:
Current Allergy and Asthma Reports. 3:159-165
Although the role of eosinophils, mast cells, and T cells in asthma has long been recognized, several reports suggest that neutrophils may also be involved. In most studies of people with mild asthma, neutrophil numbers in the airways are not differe
Publikováno v:
Chest. 122:955-959
Study objectives: Induced sputum is used to investigate pulmonary diseases. Low-output ultrasonic nebulizers have become available and have potential advantages over high-output nebulizers. We hypothesized that a low-output nebulizer would give compa