Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Michael J. Owens"'
Autor:
Jason Lazar, Anna V. Rozenboym, Sasha L. Fulton, Lakshmi Thiramangalakdi, Haroon Kamran, Jean Tang, John G. Kral, Venkatesh Panthangi, Jeremy D. Coplan, Tarique D. Perera, Michael J. Owens, Yang Liu, Charles B. Nemeroff, Leonard A. Rosenblum, Louis Salciccioli
Publikováno v:
Neurobiology of Stress, Vol 8, Iss, Pp 202-210 (2018)
Neurobiology of Stress
Neurobiology of Stress
Background: Early life stress (ELS) in macaques in the form of insecure maternal attachment putatively induces epigenetic adaptations resulting in a “thrifty phenotype” throughout the life cycle. For instance, ELS induces persistent increases in
Autor:
Eric P. Smith, Leonard A. Rosenblum, Shariful A. Syed, Michael J. Owens, Olcay Batuman, Charles B. Nemeroff, Jeremy D. Coplan
Publikováno v:
Neuroscience Letters. 647:20-25
Introduction Early life stress (ELS) has been shown to play a role in establishing persistent maladaptive HPA axis modifications that may contribute to the pathogenesis of mood and anxiety disorders. Central glucocorticoid receptor (GR) messenger RNA
Publikováno v:
Neurotoxicology and Teratology. 39:100-109
Stress and/or antidepressants during pregnancy have been implicated in a wide range of long-term effects in the offspring. We investigated the long-term effects of prenatal stress and/or clinically relevant antidepressant exposure on male adult offsp
Autor:
Gretchen N. Neigh, Michael J. Owens, Christina L. Nemeth, Zachary N. Stowe, Sean D. Kelly, Emily E. Hardy, Chase H. Bourke
Publikováno v:
Physiologybehavior. 172
Prenatal stress has been linked to deficits in neurological function including deficient social behavior, alterations in learning and memory, impaired stress regulation, and susceptibility to adult disease. In addition, prenatal environment is known
Publikováno v:
Biological Psychiatry. 72:238-243
Background Neurochemical studies have pointed to a modulatory role in human aggression for a variety of central neurotransmitters; some seem to play an inhibitory role, whereas others seem to play a facilitory role in the modulation of aggression. La
Publikováno v:
Neuropharmacology. 60:1135-1141
Corticotropin-releasing factor (CRF) functions as one of the major mediators of the mammalian stress response and appears to play a key role in the pathophysiology of mood and anxiety disorders. Small molecule CRF₁ receptor antagonists may represen
Autor:
Joan Kaufman, Michael J. Owens, Joel Gelernter, Arie Kaffman, Tarique D. Perera, Eric L. Smith, Charles B. Nemeroff, Chadi G. Abdallah, Leonard A. Rosenblum, Jeremy D. Coplan, Andrew J. Dwork, Jack M. Gorman
Publikováno v:
Psychoneuroendocrinology. 36:289-293
Recent studies have indicated a gene by environment interaction between serotonin transporter gene (5-HTTLPR) polymorphism and childhood abuse on depressive symptoms. In addition, persistent elevation of cerebrospinal fluid (CSF) corticotropin-releas
Publikováno v:
Psychopharmacology. 192:385-396
Corticotropin-releasing factor (CRF) is the primary physiologic regulator of the hypothalamic-pituitary-adrenal (HPA) axis and serves to globally coordinate the mammalian stress response. Hyperactivity of central nervous system CRF neurotransmission,
Autor:
Zachary N. Stowe, Courtney A. Sholar, Steven J. Ryan, Gretchen N. Neigh, David E. Ehrlich, Nesha Jairam, Chase H. Bourke, Sydney A. Rowson, Michael J. Owens, Rimi Hazra, Christina L. Nemeth, Donald G. Rainnie
Depression during pregnancy has been linked to in utero stress and is associated with long-lasting symptoms in offspring, including anxiety, helplessness, attentional deficits, and social withdrawal. Depression is diagnosed in 10-20% of expectant mot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc6257e2a17cd548b2c3904bc2e8cbdf
https://europepmc.org/articles/PMC4537355/
https://europepmc.org/articles/PMC4537355/
Autor:
Dewleen G. Baker, Linda L. Carpenter, Paul S. Horn, Thomas D. Geracioti, Jeffrey R. Strawn, Gerard Sanacora, Becky Kinkead, Lawrence H. Price, Charles B. Nemeroff, Nosakhare N. Ekhator, Michael J. Owens
Publikováno v:
American Journal of Psychiatry. 163:637-643
Objective: The authors tested the hypothesis that concentrations of the paintransmitting neuropeptide substance P are elevated in the CSF of patients with major depression or posttraumatic stress disorder (PTSD), which have overlapping symptoms. The