Zobrazeno 1 - 10
of 39
pro vyhledávání: '"John M Coffin"'
Autor:
John M. Coffin, Rebecca Hoh, Jason W. Rausch, Brandon F. Keele, Frank Maldarelli, Sean C Patro, Christine M. Fennessey, Shuang Guo, Christopher Hautman, Leah D. Brandt, Brian T. Luke, Elias K. Halvas, Steven G. Deeks, Kevin W. Joseph, Wei Shao, Michael J. Bale, Adam A. Capoferri, Aurelie Niyongabo, Michele D. Sobolewski, Jonathan Spindler, Xiaolin Wu, Jeffrey M. Milush, Stephen H. Hughes, Ben Murrell, John W. Mellors, Castle Raley, Mary F. Kearney, Jenna M Hasson, Wei-Shau Hu, Ann Wiegand
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 51
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Understanding HIV-1 persistence despite antiretroviral therapy (ART) is of paramount importance. Both single-genome sequencing (SGS) and integration site analysis (ISA) provide useful information regarding the structure of persistent HIV DNA populati
Autor:
John M. Coffin, Stephen H. Hughes
Publikováno v:
Viruses
Viruses, Vol 13, Iss 2078, p 2078 (2021)
Viruses, Vol 13, Iss 2078, p 2078 (2021)
HIV infection is not curable with current antiretroviral therapy (ART) because a small fraction of CD4+ T cells infected prior to ART initiation persists. Understanding the nature of this latent reservoir and how it is created is essential to develop
Autor:
David Jetton, Rebecca E. Brown, Machika Kaku, John M. Coffin, Daria Wells, John K Yoon, Joseph R Holloway
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
In vivo clonal expansion of HIV-infected T cells is an important mechanism of viral persistence. In some cases, clonal expansion is driven by HIV proviral DNA integrated into one of a handful of genes. To investigate this phenomenon in vitro, we infe
Autor:
John M. Coffin, Wei Shao, Brandon F. Keele, Cristina Ceriani, Jason W. Rausch, Jeffrey M. Milush, Valerie F. Boltz, Frank Maldarelli, Rebecca Hoh, Steve Deeks, Michael J. Bale, Mary F. Kearney
Publikováno v:
Viruses, Vol 13, Iss 799, p 799 (2021)
Viruses, vol 13, iss 5
Viruses
Volume 13
Issue 5
Viruses, vol 13, iss 5
Viruses
Volume 13
Issue 5
The latent HIV-1 reservoir is comprised of stably integrated and intact proviruses with limited to no viral transcription. It has been proposed that latent infection may be maintained by methylation of pro-viral DNA. Here, for the first time, we inve
Autor:
Wei Shao, John M. Coffin, Stephen H. Hughes, Daria Wells, Michele D. Sobolewski, Xiaolin Wu, Jennifer M. Zerbato, Twan Sia, Frank Maldarelli, Michael J. Bale, John W. Mellors, Shuang Guo, Brian T. Luke, Mary F. Kearney
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009141 (2021)
PLoS Pathogens
PLoS Pathogens
HIV persists during antiretroviral therapy (ART) as integrated proviruses in cells descended from a small fraction of the CD4+ T cells infected prior to the initiation of ART. To better understand what controls HIV persistence and the distribution of
Autor:
John M. Coffin
Publikováno v:
Molecular biology of the cell. 32(2)
The simultaneous discovery in 1970 of reverse transcriptase in virions of retroviruses by Howard Temin and David Baltimore was perhaps the most dramatic scientific moment of the second half of the 20th century. Ten years previously, Temin’s observa
Autor:
Michele D. Sobolewskii, Shuang Guo, Wei Shao, John M. Coffin, Michael J. Bale, Jennifer M. Zerbato, Brian T. Luke, Frank Maldarelli, Mary F. Kearney, Xiaolin Wu, Daria Wells, John W. Mellors, Twan Sia, Stephen H. Hughes
HIV persists during antiretroviral therapy (ART) as integrated proviruses in cells descended from a small fraction of the CD4+ T cells infected prior to the initiation of ART. To better understand what controls HIV persistence and the distribution of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e33a876bfde7d4ec6be45e197aa590e7
https://doi.org/10.1101/2020.11.25.397653
https://doi.org/10.1101/2020.11.25.397653
Autor:
Stephen H. Hughes, Shawn Hill, Elizabeth M. Anderson, Francesco R. Simonetti, Eli Boritz, Mary F. Kearney, Frank Maldarelli, Daria Wells, Xiaolin Wu, Venigalla B. Rao, Catherine Rehm, Jennifer Bell, John M. Coffin, Robert J. Gorelick, Liliana Pérez, Monica A Gouzoulis
Publikováno v:
Viruses
Viruses, Vol 12, Iss 2, p 136 (2020)
Volume 12
Issue 2
Viruses, Vol 12, Iss 2, p 136 (2020)
Volume 12
Issue 2
Combination antiretroviral therapy (cART) controls but does not eradicate HIV infection
HIV persistence is the principal obstacle to curing infections. The proportion of defective proviruses increases during cART, but the dynamics of this proces
HIV persistence is the principal obstacle to curing infections. The proportion of defective proviruses increases during cART, but the dynamics of this proces
Autor:
John M. Coffin, Meagan Montesion, Ravi P. Subramanian, Charlotte Kuperwasser, Zachary H. Williams
Publikováno v:
Retrovirology, Vol 15, Iss 1, Pp 1-16 (2018)
Retrovirology
Retrovirology
Background Increased transcription of the human endogenous retrovirus group HERV-K (HML-2) is often seen during disease. Although the mechanism of its tissue-specific activation is unclear, research shows that LTR CpG hypomethylation alone is not suf
Autor:
Michael J. Bale, Sean C Patro, Wei Shao, Andrew Musick, Francesco R. Simonetti, Jonathan Spindler, Carolyn Reid, Mary F. Kearney, Brandon F. Keele, Stephen H. Hughes, John M. Coffin, Michele D. Sobolewski, Frank Maldarelli, Liliana Pérez, Daniel Crespo-Vélez, Eli Boritz, Adam A. Capoferri, Ann Wiegand, John W. Mellors
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Frontiers in Microbiology
Frontiers in Microbiology
Background HIV-1 proviruses can persist during ART in clonally-expanded populations of CD4+ T cells. To date, few examples of an expanded clones containing replication-competent proviruses exist, although it is suspected to be common. One such clone,