Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Ana Martinez-Val"'
Autor:
Claire Koenig, Ana Martinez-Val, Previn Naicker, Stoyan Stoychev, Justin Jordaan, Jesper V. Olsen
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102536- (2023)
Summary: Tandem mass tags data-dependent acquisition (TMT-DDA) as well as data-independent acquisition-based label-free quantification (LFQ-DIA) have become the leading workflows to achieve deep proteome and phosphoproteome profiles. We present a mod
Externí odkaz:
https://doaj.org/article/9ba21261ada24d17b97598b856fe573d
Autor:
Marta Rojas-Torres, Lucía Beltrán-Camacho, Ana Martínez-Val, Ismael Sánchez-Gomar, Sara Eslava-Alcón, Antonio Rosal-Vela, Margarita Jiménez-Palomares, Esther Doiz-Artázcoz, Mario Martínez-Torija, Rafael Moreno-Luna, Jesper V. Olsen, Ma. Carmen Duran-Ruiz
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-20 (2024)
Abstract Background Critical limb-threatening ischemia (CLTI) constitutes the most severe manifestation of peripheral artery disease, usually induced by atherosclerosis. CLTI patients suffer from high risk of amputation of the lower extremities and e
Externí odkaz:
https://doaj.org/article/27bcbf1ec51e4b22868a84f0473da65b
Autor:
Jesper V. Olsen, Jos G. A. Smits, Sonia Minuzzo, Giulia Franciosa, Ana Martinez-Val, Stefano Indraccolo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, 12, 1-19
Nature Communications, 12, 1, pp. 1-19
Nature Communications
Franciosa, G, Smits, J G A, Minuzzo, S, Martinez-Val, A, Indraccolo, S & Olsen, J V 2021, ' Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures ', Nature Communications, vol. 12, no. 1, 2507 . https://doi.org/10.1038/s41467-021-22787-9
Nature Communications, 12, 1-19
Nature Communications, 12, 1, pp. 1-19
Nature Communications
Franciosa, G, Smits, J G A, Minuzzo, S, Martinez-Val, A, Indraccolo, S & Olsen, J V 2021, ' Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures ', Nature Communications, vol. 12, no. 1, 2507 . https://doi.org/10.1038/s41467-021-22787-9
Notch1 is a crucial oncogenic driver in T-cell acute lymphoblastic leukemia (T-ALL), making it an attractive therapeutic target. However, the success of targeted therapy using γ-secretase inhibitors (GSIs), small molecules blocking Notch cleavage an
Publikováno v:
Martinez-Val, A, Guzmán, U H & Olsen, J V 2022, ' Obtaining Complete Human Proteomes ', Annual Review of Genomics and Human Genetics, vol. 23, pp. 10.1-10.23 . https://doi.org/10.1146/annurev-genom-112921-024948
Proteins are the molecular effectors of the information encoded in the genome. Proteomics aims at understanding the molecular functions of proteins in their biological context. In contrast to transcriptomics and genomics, the study of proteomes provi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a7b8e064b9b2c0e8fbe09a058ee2f5
https://curis.ku.dk/ws/files/358428665/annurev_genom_112921_024948.pdf
https://curis.ku.dk/ws/files/358428665/annurev_genom_112921_024948.pdf
Autor:
Ana Martinez-Val, Dorte B. Bekker-Jensen, Sophia Steigerwald, Claire Koenig, Ole Østergaard, Adi Mehta, Trung Tran, Krzysztof Sikorski, Estefanía Torres-Vega, Ewa Kwasniewicz, Sólveig Hlín Brynjólfsdóttir, Lisa B. Frankel, Rasmus Kjøbsted, Nicolai Krogh, Alicia Lundby, Simon Bekker-Jensen, Fridtjof Lund-Johansen, Jesper V. Olsen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Martinez-Val, A, Bekker-Jensen, D B, Steigerwald, S, Koenig, C, Østergaard, O, Mehta, A, Tran, T, Sikorski, K, Torres-Vega, E, Kwasniewicz, E, Brynjólfsdóttir, S H, Frankel, L B, Kjøbsted, R, Krogh, N, Lundby, A, Bekker-Jensen, S, Lund-Johansen, F & Olsen, J V 2021, ' Spatial-proteomics reveals phospho-signaling dynamics at subcellular resolution ', Nature Communications, vol. 12, no. 1, 7113 . https://doi.org/10.1038/s41467-021-27398-y
Nature Communications
Martinez-Val, A, Bekker-Jensen, D B, Steigerwald, S, Koenig, C, Østergaard, O, Mehta, A, Tran, T, Sikorski, K, Torres-Vega, E, Kwasniewicz, E, Brynjólfsdóttir, S H, Frankel, L B, Kjøbsted, R, Krogh, N, Lundby, A, Bekker-Jensen, S, Lund-Johansen, F & Olsen, J V 2021, ' Spatial-proteomics reveals phospho-signaling dynamics at subcellular resolution ', Nature Communications, vol. 12, no. 1, 7113 . https://doi.org/10.1038/s41467-021-27398-y
Dynamic change in subcellular localization of signaling proteins is a general concept that eukaryotic cells evolved for eliciting a coordinated response to stimuli. Mass spectrometry-based proteomics in combination with subcellular fractionation can
Autor:
Ana, Martinez-Val, Dorte Breinholdt, Bekker-Jensen, Alexander, Hogrebe, Jesper Velgaard, Olsen
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2361
Data-independent acquisition (DIA) for liquid chromatography tandem mass spectrometry (LC-MS/MS) can improve the depth and reproducibility of the acquired proteomics datasets. DIA solves some limitations of the conventional data-dependent acquisition
Publikováno v:
Expert Review of Proteomics. 16:391-400
INTRODUCTION Pluripotency emerges transiently during embryogenesis in two main forms with different developmental potential, termed naive and primed states. Importantly, these pluripotent states can be recapitulated in vitro under specific culture co
Autor:
Fridtjof Lund-Johansen, Nicolai Krogh, Brynjólfsdóttir Sh, Simon Bekker-Jensen, Steigerwald S, Jesper V. Olsen, Rasmus Kjøbsted, Trung Tran, Adi Mehta, Kwasniewicz E, Sikorski K, Alicia Lundby, Dorte B. Bekker-Jensen, Torres-Vega E, Lisa B. Frankel, Ana Martinez-Val
Dynamic change in subcellular localization of signaling proteins is a general concept that eukaryotic cells evolved for eliciting a coordinated response to stimuli. Mass spectrometry (MS)-based proteomics in combination with subcellular fractionation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::311a686b81f8ea6138ac4c78211fef74
https://doi.org/10.1101/2021.02.02.425898
https://doi.org/10.1101/2021.02.02.425898
Autor:
Ana Martinez-Val, Fernando García, Isabel A. Calvo, Eduardo Zarzuela, Pilar Ximénez-Embún, Cian J. Lynch, Manuel Serrano, Javier Munoz
Publikováno v:
Nature Communications
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Embryonic stem cells (ESCs) can be maintained in the naïve state through inhibition of Mek1/2 and Gsk3 (2i). A relevant effect of 2i is the inhibition of Cdk8/19, which are negative regulators of the Mediator complex, responsible for the activity of
Autor:
Tejas Gandhi, Ana Martinez-Val, Christian D. Kelstrup, Lynn Verbeke, Dorte B. Bekker-Jensen, Oliver M. Bernhardt, Lukas Reiter, Alexander Hogrebe, Jesper V. Olsen
Publikováno v:
Bekker-Jensen, D B, Bernhardt, O M, Hogrebe, A, Martinez-Val, A, Verbeke, L, Gandhi, T, Kelstrup, C D, Reiter, L & Olsen, J V 2020, ' Rapid and site-specific deep phosphoproteome profiling by data-independent acquisition without the need for spectral libraries ', Nature Communications, vol. 11, no. 1, 787 . https://doi.org/10.1038/s41467-020-14609-1
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Quantitative phosphoproteomics has transformed investigations of cell signaling, but it remains challenging to scale the technology for high-throughput analyses. Here we report a rapid and reproducible approach to analyze hundreds of phosphoproteomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e453d00707c07c35b75c671a2f2b94a
https://curis.ku.dk/portal/da/publications/rapid-and-sitespecific-deep-phosphoproteome-profiling-by-dataindependent-acquisition-without-the-need-for-spectral-libraries(c58b93b3-99f8-4b09-897a-9c279dc8d2c3).html
https://curis.ku.dk/portal/da/publications/rapid-and-sitespecific-deep-phosphoproteome-profiling-by-dataindependent-acquisition-without-the-need-for-spectral-libraries(c58b93b3-99f8-4b09-897a-9c279dc8d2c3).html