Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Olena Barbash"'
Autor:
Andrew Fedoriw, Leilei Shi, Shane O'Brien, Kimberly N. Smitheman, Yunfei Wang, Jiakai Hou, Christian Sherk, Satyajit Rajapurkar, Jenny Laraio, Leila J. Williams, Chunyu Xu, Guangchun Han, Qin Feng, Mark T. Bedford, Linghua Wang, Olena Barbash, Ryan G. Kruger, Patrick Hwu, Helai P. Mohammad, Weiyi Peng
Publikováno v:
Cancer Immunol Res
Protein arginine methyltransferases (PRMT) are a widely expressed class of enzymes responsible for catalyzing arginine methylation on numerous protein substrates. Among them, type I PRMTs are responsible for generating asymmetric dimethylarginine. By
Autor:
Tatiana Erazo, Chiara M. Evans, Daniel Zakheim, Karen L. Chu, Alice Yunsi Refermat, Zahra Asgari, Xuejing Yang, Mariana Da Silva Ferreira, Sanjoy Mehta, Marco Vincenzo Russo, Andrea Knezevic, Xi-Ping Zhang, Zhengming Chen, Myles Fennell, Ralph Garippa, Venkatraman Seshan, Elisa de Stanchina, Olena Barbash, Connie Lee Batlevi, Christina S. Leslie, Ari M. Melnick, Anas Younes, Michael G. Kharas
Publikováno v:
Nature communications. 13(1)
To identify drivers of sensitivity and resistance to Protein Arginine Methyltransferase 5 (PRMT5) inhibition, we perform a genome-wide CRISPR/Cas9 screen. We identify TP53 and RNA-binding protein MUSASHI2 (MSI2) as the top-ranked sensitizer and drive
Publikováno v:
Nature Medicine. 25:403-418
Epigenetic dysregulation is a common feature of most cancers, often occurring directly through alteration of epigenetic machinery. Over the last several years, a new generation of drugs directed at epigenetic modulators have entered clinical developm
Autor:
Tiziana Bonaldi, Cheryl M. Koh, Cheryl H. Arrowsmith, Christine Thompson, Heike Wollmann, Bas J. Wouters, Luca Pignata, Jia Yi Fong, Magdalena M. Szewczyk, Ari Melnick, Dalia Barsyte-Lovejoy, Daniele Musiani, Cheng Mun Wun, Alex Penson, Pierre-Alexis Goy, Jian Jin, Eirini P. Papapetrou, Mark D. Minden, Enrico Massignani, Genna M. Luciani, Omar Abdel-Wahab, Olena Barbash, Ernesto Guccione, Ruud Delwel, Diana Hp. Low, Michelle Ki, Alexander Rialdi, Kimihito Cojin Kawabata, Andriana G. Kotini, Timothy K. Hart, Megan C. Schwarz, Slim Mzoughi, Yudao Shen, Stanley Chun-Wei Lee
Publikováno v:
Cancer Cell, 36(2), 194-+. Cell Press
Cancer Cell
Cancer Cell
Cancer-associated mutations in genes encoding RNA splicing factors (SFs) commonly occur in leukemias, as well as in a variety of solid tumors, and confer dependence on wild-type splicing. These observations have led to clinical efforts to directly in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1abc1c9ad1c9c46107e079dc43598e0c
https://pure.eur.nl/en/publications/4ea6f5b5-7be9-43d4-bebe-69e3c9d77205
https://pure.eur.nl/en/publications/4ea6f5b5-7be9-43d4-bebe-69e3c9d77205
Autor:
Rocio Montes de Oca, Christopher L. Carpenter, Michael T. McCabe, Christine Thompson, Ann Boriack-Sjodin, Xi-Ping Zhang, Wendy A. Kellner, Kenneth W. Duncan, Melissa B. Pappalardi, Sarah Gerhart, Olena Barbash, Johnson Neil W, Ryan G. Kruger, BaoChau Le, Christina R. Majer, Elayne Penebre
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Evasion of the potent tumour suppressor activity of p53 is one of the hurdles that must be overcome for cancer cells to escape normal regulation of cellular proliferation and survival. In addition to frequent loss of function mutations, p53 wild-type
Autor:
Kelly Chiang, Agnieszka E. Zielinska, Abeer M. Shaaban, Maria Pilar Sanchez-Bailon, James Jarrold, Thomas L. Clarke, Jingxian Zhang, Adele Francis, Louise J. Jones, Sally Smith, Olena Barbash, Ernesto Guccione, Gillian Farnie, Matthew J. Smalley, Clare C. Davies
Publikováno v:
Cell Reports
Cell Reports, Vol 21, Iss 12, Pp 3498-3513 (2017)
Cell Reports, Vol 21, Iss 12, Pp 3498-3513 (2017)
Summary Breast cancer progression, treatment resistance, and relapse are thought to originate from a small population of tumor cells, breast cancer stem cells (BCSCs). Identification of factors critical for BCSC function is therefore vital for the de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::00806a6998cff3fa8612eb0980054ebf
https://ora.ox.ac.uk/objects/uuid:c8dac21c-ded6-4d62-9b35-2dc22ab73d57
https://ora.ox.ac.uk/objects/uuid:c8dac21c-ded6-4d62-9b35-2dc22ab73d57