Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Tomi P. Mäkelä"'
Autor:
Yajing, Gao, Yan, Yan, Sushil, Tripathi, Nalle, Pentinmikko, Ana, Amaral, Pekka, Päivinen, Eva, Domènech-Moreno, Simon, Andersson, Iris P L, Wong, Hans, Clevers, Pekka, Katajisto, Tomi P, Mäkelä
Publikováno v:
Gastroenterology. 158(5)
In addition to the Notch and Wnt signaling pathways, energy metabolism also regulates intestinal stem cell (ISC) function. Tumor suppressor and kinase STK11 (also called LKB1) regulates stem cells and cell metabolism. We investigated whether loss of
Autor:
Tomi P. Mäkelä, Kari Vaahtomeri, Yajing Gao, Sushil Tripathi, Iris P. L. Wong, Benoit Viollet, Eva Domenech-Moreno, Yan Yan, Nalle Pentinmikko, Timothy C. Wang, Gustavo Leone, Elina H. Niemelä, Saara Ollila, Kaisa Laajanen, Pekka Katajisto
Publikováno v:
Journal of Clinical Investigation
Journal of Clinical Investigation, 2018, 128 (1), pp.402-414. ⟨10.1172/JCI93597⟩
Journal of Clinical Investigation, American Society for Clinical Investigation, 2018, 128 (1), pp.402-414. ⟨10.1172/JCI93597⟩
Journal of Clinical Investigation, 2018, 128 (1), pp.402-414. ⟨10.1172/JCI93597⟩
Journal of Clinical Investigation, American Society for Clinical Investigation, 2018, 128 (1), pp.402-414. ⟨10.1172/JCI93597⟩
International audience; Germline mutations in the gene encoding tumor suppressor kinase LKB1 lead to gastrointestinal tumorigenesis in Peutz-Jeghers syndrome (PJS) patients and mouse models; however, the cell types and signaling pathways underlying t
Publikováno v:
EMBO reports. 14:741-747
Loss of primary cilia is frequently observed in tumour cells, including glioblastoma cells, and proposed to benefit tumour growth, but a causal link has not been established. Here, we show that CCRK (cell cycle-related kinase) and its substrate ICK (
Autor:
Lina Udd, Tomi P. Mäkelä
Publikováno v:
Familial Cancer. 10:425-435
The Peutz-Jeghers syndrome (PJS) culprit kinase LKB1 phosphorylates and activates multiple intracellular kinases regulating cell metabolism and polarity. The relevance of each of these pathways is highly variable depending on the tissue type, but typ
Autor:
Niklas Ekman, Marianne Tiainen, Tea Vallenius, Pekka Katajisto, Tomi P. Mäkelä, Kari Vaahtomeri, Anou Londesborough
Publikováno v:
Development. 135:2331-2338
Inactivation of the tumor suppressor kinase Lkb1 in mice leads to vascular defects and midgestational lethality at embryonic day 9-11 (E9-E11). Here, we have used conditional targeting to investigate the defects underlying the Lkb1(-/-) phenotype. En
Autor:
Tea Vallenius, Lina Udd, Kari Vaahtomeri, Tomi P. Mäkelä, Marianne Tiainen, Pekka Katajisto, Niklas Ekman
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1775:63-75
Inactivating germline mutations in the LKB1 gene underlie Peutz-Jeghers syndrome characterized by hamartomatous polyps and an elevated risk for cancer. Recent studies suggest the involvement of LKB1 also in more common human disorders including diabe
Autor:
Lina Udd, Jérôme Boudeau, Jose M. Lizcano, Simon A. Hawley, Olga Göransson, Rachel Toth, Tomi P. Mäkelä, Dario R. Alessi, D. Grahame Hardie, Maria Deak, Nick A. Morrice
Publikováno v:
The EMBO Journal. 23:833-843
We recently demonstrated that the LKB1 tumour suppressor kinase, in complex with the pseudokinase STRAD and the scaffolding protein MO25, phosphorylates and activates AMP-activated protein kinase (AMPK). A total of 12 human kinases (NUAK1, NUAK2, BRS
Autor:
Lauri A. Aaltonen, Virpi Launonen, Keijo Luukko, Nina Korsisaari, Tomi P. Mäkelä, Ari Ristimäki, Antti Ylikorkala, Mark Henkemeyer, Derrick J. Rossi, Reijo Salovaara
Publikováno v:
Proceedings of the National Academy of Sciences. 99:12327-12332
Inactivating germ-line mutations of LKB1 lead to Peutz–Jeghers syndrome (PJS). We have generated mice heterozygous for a targeted inactivating allele of Lkb1 and found that they develop severe gastrointestinal polyposis. In all cases, the polyps ar
Autor:
Tea Vallenius, Tomi P. Mäkelä
Publikováno v:
Journal of Cell Science. 115:2067-2073
In this report we have characterized a novel, ubiquitously expressed kinase, Clik1, that is predominantly nuclear and undergoes autophosphorylation. Yeast two-hybrid analysis indicated a highly specific association between Clik1 and CLP-36, which was
Autor:
Derrick J. Rossi, Kari Alitalo, Antti Ylikorkala, Nina Korsisaari, Keijo Luukko, Tomi P. Mäkelä, Mark Henkemeyer
Publikováno v:
Science. 293:1323-1326
The LKB1 tumor suppressor gene, mutated in Peutz-Jeghers syndrome, encodes a serine/threonine kinase of unknown function. Here we show that mice with a targeted disruption of Lkb1 die at midgestation, with the embryos showing neural tube defects, mes