Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Tomi P. Mäkelä"'
Autor:
Tea Vallenius, Tomi P. Mäkelä
Publikováno v:
Journal of Cell Science. 115:2067-2073
In this report we have characterized a novel, ubiquitously expressed kinase, Clik1, that is predominantly nuclear and undergoes autophosphorylation. Yeast two-hybrid analysis indicated a highly specific association between Clik1 and CLP-36, which was
Autor:
Tomi P. Mäkelä, Nina Korsisaari
Publikováno v:
Journal of Biological Chemistry. 275:34837-34840
Cyclin-dependent kinase 7 (Cdk7) forms a trimeric complex with cyclin H and Mat1 to form the mammalian Cdk-activating kinase, CAK, as well as a part of the basal transcription factor TFIIH, where Cdk7 phosphorylates the C-terminal domain (CTD) of the
Publikováno v:
Proceedings of the National Academy of Sciences. 96:9248-9251
Germ-line mutations of LKB1 ( STK11 ) lead to Peutz–Jeghers syndrome characterized by gastrointestinal polyps and cancer of different organ systems. The mutations lead to loss or severe impairment of Lkb1 serine/threonine kinase activity. Therefore
Publikováno v:
Molecular biology of the cell. 12(12)
In normal cells, activation of cyclin-dependent kinases (cdks) requires binding to a cyclin and phosphorylation by the cdk-activating kinase (CAK). The Kaposi's sarcoma-associated herpesvirus encodes a protein with similarity to D-type cyclins. This
Autor:
Päivi M. Ojala, Tomi P. Mäkelä, Kazuhito Yamamoto, Stanley J. Korsmeyer, Peter Biberfeld, Esmeralda Castaños-Velez
Publikováno v:
Nature cell biology. 2(11)
v-cyclin encoded by Kaposi's sarcoma herpesvirus/human herpesvirus 8 (KSHV or HHV8) associates with cellular cyclin-dependent kinase 6 (CDK6) to form a kinase complex that promotes cell-cycle progression, but can also induce apoptosis in cells with h
Autor:
Robert A. Weinberg, Jaesang Kim, Jeffrey D. Parvin, L. J. Huber, Tomi P. Mäkelä, Phillip A. Sharp
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 92(11)
Phosphorylation of the carboxyl-terminal domain (CTD) of the large subunit of RNA polymerase II has been suggested to be critical for transcription initiation, activation, or elongation. A kinase activity specific for CTD is a component of the genera