Zobrazeno 1 - 10
of 25
pro vyhledávání: '"George Hsiao"'
Autor:
Joen Rong Sheu, Cheng Ying Hsieh, Thanasekaran Jayakumar, Chao Chien Chang, Jie Jen Lee, George Hsiao, Cheng-Wen Chiang
Publikováno v:
Pharmaceutical Biology. 48:938-946
Vascular smooth muscle cells (VSMCs) play a major role in the pathogenesis of atherosclerosis and restenosis, and thus the excessive proliferation of VSMCs contributes to neointimal thickening during atherosclerosis and restenosis. PMC (2,2,5,7,8-pen
Publikováno v:
Pharmacological Research. 57:151-158
The amyloid beta peptide (Abeta), a mediator of neuronal and vascular degeneration in the pathogenesis of Alzheimer's disease and cerebral amyloid angiopathy may have peripheral actions. Platelets are enriched with Abeta and have been shown to enhanc
Autor:
Kuang H. Lin, Tsorng H. Fong, Chia H. Shen, Joen R. Sheu, Duen S. Chou, George Hsiao, Jie J. Lee
Publikováno v:
Cardiovascular Research. 75:782-792
Caffeic acid phenethyl ester (CAPE), which is derived from the propolis of honeybee hives, has been demonstrated to possess multiple pharmacological activities. In the present study, CAPE (6-25 microM) specifically inhibited collagen-induced platelet
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 25:1998-2004
Objective— Inosine is a naturally occurring nucleoside degraded from adenosine. Recent studies have demonstrated that inosine has potent immunomodulatory and neuroprotective effects. In the present study, we further investigated the inhibitory effe
Autor:
Gong Jhe Wu, Chien-Huang Lin, Ming Yi Shen, George Hsiao, Joen Rong Sheu, Duen Suey Chou, Yi Chang, Ta Liang Chen, Kuan Hung Lin
Publikováno v:
Journal of Biomedical Science. 11:764-772
The aim of this study was to systematically examine the inhibitory mechanisms of ketamine in platelet aggregation. In this study, ketamine concentration-dependently (100-350 microM) inhibited platelet aggregation both in washed human platelet suspens
Autor:
Tsorng-Harn Fong, Ming Y. Shen, Meng S. Lu, Yi Chang, Joen Rong Sheu, Ta-Liang Chen, Cheng-Ming Liu, George Hsiao
Publikováno v:
British Journal of Pharmacology. 143:193-201
1. The aim of this study was to identify the presence of matrix metalloproteinase-9 (MMP-9) in human platelets and systematically examine its inhibitory mechanisms of platelet activation. 2. In this study, we report on an efficient method for the qua
Publikováno v:
Journal of Agricultural and Food Chemistry. 52:4414-4418
The aim of this study was to systematically examine the inhibitory mechanisms of rutin, a well-known flavonoid in platelet aggregation. In this study, rutin concentration-dependently (250 and 290 microM) inhibited platelet aggregation in human platel
Autor:
Tsorng Harn Fong, George Hsiao, Hsin Yi Huang, Chen Ming Teng, Ming Yi Shen, Chien-Huang Lin, Joen Rong Sheu
Publikováno v:
Biochemical Pharmacology. 67:1411-1419
In the present study, the signal pathways involved in NO formation and iNOS expression in RAW 264.7 macrophages stimulated by LTA were investigated. We also compared the relative inhibitory activities and mechanisms of PMC, a novel potent antioxidant
Autor:
Yi Chang, Chien-Huang Lin, George Hsiao, Joen Rong Sheu, Duen Suey Chou, Ming Yi Shen, Lin Wen Lee
Publikováno v:
European Journal of Pharmacology. 487:159-166
Midazolam is widely used as a sedative and anesthetic induction agent. The aim of this study was to systematically examine the inhibitory mechanisms of midazolam in platelet aggregation. In this study, midazolam concentration-dependently (15 and 30 m
Autor:
Ming Shyan Chang, Chien-Huang Lin, Wen Sen Lee, George Hsiao, Horng Mo Lee, Joen Rong Sheu, Che-Ming Teng
Publikováno v:
British Journal of Pharmacology. 136:558-567
YC-1, an activator of soluble guanylate cyclase (sGC), has been shown to increase the intracellular cGMP concentration. This study was designed to investigate the signaling pathway involved in the YC-1-induced COX-2 expression in A549 cells. YC-1 cau