Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Ulf R, Rapp"'
Autor:
Angela Baljuls, Mirko Hekman, Ulf R. Rapp, Andreas Fischer, Werner Schmitz, Renate Metz, René P. Zahedi, Stefan Albert, Albert Sickmann, Roland Benz, Lisa Polzien, Ulrike Rennefahrt
Publikováno v:
Journal of Biological Chemistry. 284:28004-28020
BAD is a proapoptotic member of the Bcl-2 protein family that is regulated by phosphorylation in response to survival factors. Although much attention has been devoted to the identification of phosphorylation sites in murine BAD, little data are avai
Autor:
Stefan Wiese, Verena Pfeiffer, Ulf R. Rapp, Sandra Pleiser, Oleg Yu. Tyrsin, Rudolf Götz, Guadalupe Camarero, Chaomei Xiang
Publikováno v:
Molecular and Cellular Biology. 26:7103-7115
We have previously shown that mice lacking the protein kinase B-RAF have defects in both neural and endothelial cell lineages and die around embryonic day 12 (E12). To delineate the function of B-RAF in the brain, B-RAF KIN/KIN mice lacking B-RAF and
Publikováno v:
Journal of Biological Chemistry. 277:29510-29518
The c-Jun N-terminal kinases (JNKs) (also known as stress-activated protein kinases or SAPKs), members of the mitogen-activated protein kinase (MAPK) family, regulate gene expression in response to a variety of physiological and unphysiological stimu
Autor:
Peifeng Chen, Stephan Ludwig, Bruce W.M. Jordan, Egbert Flory, Frank Kirchhoff, Ulf R. Rapp, Andris Avots
Publikováno v:
Journal of Biological Chemistry. 275:20382-20390
To study the role of MAPK cascades in the regulation of naturally occurring human immunodeficiency virus type 1 long terminal repeats (HIV-1 LTRs), we analyzed several HIV-1 LTRs from patients at different stages of disease progression. One of these
Autor:
Egbert Flory, Bernd Neufeld, Angelika Hoffmeyer, Stephan Ludwig, Ulf R. Rapp, Anne Grosse-Wilde, Manfred Kunz
Publikováno v:
Journal of Biological Chemistry. 274:4319-4327
Tumor necrosis factor a (TNF-alpha) is a potent proinflammatory cytokine and plays a crucial role in early events of inflammation. TNF-alpha is primarily produced by monocytes and T lymphocytes. In particular, T-cell-derived TNF-alpha plays a critica
Autor:
Stephan Ludwig, Ulf R. Rapp, Eva B. Bröcker, Reinhard Gillitzer, Teizo Yoshimura, Manfred Kunz, Karin Kilian, Matthias Goebeler
Publikováno v:
Blood. 93:857-865
Monocyte chemoattractant protein-1 (MCP-1), a member of the C-C subfamily of chemokines, is important for the local recruitment of leukocytes to sites of inflammatory challenge. Here, we investigated endothelial signaling pathways involving members o
Autor:
Ulf R. Rapp, Anne M. Zimmer, Andreas Zimmer, Louis F. Stancato, Andrew C. Larner, Leszek Wojnowski, Heidi Hahn, Thomas William Beck
Publikováno v:
Mechanisms of Development. 76:141-149
The three mammalian Raf serine/threonine protein kinases mediate the transduction of proliferative and differentiative signals from a variety of cell surface receptors to the nucleus. We report here that Craf-1 is essential for mouse development, as
Autor:
Egbert Flory, Andris Avots, Ulf R. Rapp, Christoph K. Weber, Edgar Serfling, Angelika Hoffmeyer
Publikováno v:
Journal of Biological Chemistry. 273:10112-10119
T cell activation leads via multiple intracellular signaling pathways to rapid induction of interleukin-2 (IL-2) expression, which can be mimicked by costimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA) and ionomycin. We have identified a di
Publikováno v:
Cell. 87(4):629-638
A green fluorescent protein (GFP)–Raf-1 fusion protein was used to show that Bcl-2 can target this kinase to mitochondria. Active Raf-1 fused with targeting sequences from an outer mitochondrial membrane protein protected cells from apoptosis and r
Publikováno v:
Journal of Virology. 70:2260-2268
The serine/threonine protein kinase Raf-1 is a component of a conserved intracellular signaling cascade that controls responses to various extracellular stimuli. Transcription from several promoters, including the oncogene-responsive element in the p