Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Robert A. Lazarus"'
Autor:
Charles Eigenbrot, William F. Forrest, Yvonne Franke, Henry R. Maun, Peter Liu, Lawrence B. Schwartz, Robert A. Lazarus
Publikováno v:
Journal of Biological Chemistry. 293:9614-9628
Human β-tryptase, a tetrameric trypsin-like serine protease, is an important mediator of the allergic inflammatory responses in asthma. During acute hypersensitivity reactions, mast cells degranulate, releasing active tetramer as a complex with prot
Autor:
Kyle E. Landgraf, Clifford Quan, Charles Eigenbrot, Henry R. Maun, Jeffrey Tom, Micah Steffek, Lydia Santell, Robert A. Lazarus, Christine Yu
Publikováno v:
Nature Chemical Biology. 10:567-573
Stimulation of hepatocyte growth factor (HGF) signaling through the Met receptor is an attractive approach for promoting tissue repair and preventing fibrosis. Using structure-guided peptide phage display combined with an activity-based sorting strat
Autor:
Salina Louie, Shahram Misaghi, Cynthia Lam, Robert A. Lazarus, David E. Shaw, Lydia Santell, Brad Snedecor, Mandy Yim, Danming Tang, Pamela Chan, Blair Wilson
Publikováno v:
Biotechnology progress. 33(2)
While the most common causes of clonal instability are DNA copy number loss and silencing, toxicity of the expressed protein(s) may also induce clonal instability. Human DNase I (hDNase I) is used therapeutically for the treatment of cystic fibrosis
Publikováno v:
Nature Biotechnology. 35:28-29
Predicting the evolutionary ancestors of a protein drug provides a strategy for optimizing its pharmaceutical properties.
Autor:
Frederic J. de Sauvage, Suzie J. Scales, Henry R. Maun, Xiaohui Wen, Robert A. Lazarus, Sarah G. Hymowitz, Andreas Lingel
Publikováno v:
Journal of Biological Chemistry. 285:26570-26580
Proper hedgehog (Hh) signaling is crucial for embryogenesis and tissue regeneration. Dysregulation of this pathway is associated with several types of cancer. The monoclonal antibody 5E1 is a Hh pathway inhibitor that has been extensively used to elu
Autor:
Tony H. Dodge, Robert A. Lazarus, Dana L. Baker, Clark Q. Pan, Dominick Sinicropi, William S. Prince
Publikováno v:
Journal of Biological Chemistry. 273:18374-18381
The ability of recombinant human DNase I (DNase I) to degrade DNA to lower molecular weight fragments is the basis for its therapeutic use in cystic fibrosis (CF) patients and its potential use as a treatment for systemic lupus erythematosus (SLE). T
Autor:
Robert A. Lazarus, Michael T. Lipari, Charles Eigenbrot, John Ridgway, Lydia Santell, Paul Moran, Wendy Sandoval, Karen Billeci, Daniel Kirchhofer, Henry R. Maun
Hepatocyte growth factor (HGF), the ligand for the receptor tyrosine kinase Met, is secreted as single chain pro-HGF that lacks signaling activity. Pro-HGF acquires functional competence upon cleavage between R494 and V495, generating a disulfide-lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3825663ee8d93e2764cd13a16ec83a7
https://europepmc.org/articles/PMC1828710/
https://europepmc.org/articles/PMC1828710/
Autor:
Robert A. Lazarus, Clark Q. Pan
Publikováno v:
Biochemistry. 36(22)
Human deoxyribonuclease I (DNase I), an enzyme used to treat cystic fibrosis patients, has been engineered to more effectively degrade double-stranded DNA to lower molecular weight fragments by altering its functional mechanism from the native single
Autor:
Karen J. Toy, Andrea Herzka, Steven Shak, Anthony H. Dodge, Robert A. Lazarus, Ulmer Jana S, Dana L. Baker, Dominick Sinicropi
Human deoxyribonuclease I (DNase I), an enzyme recently approved for treatment of cystic fibrosis (CF), has been engineered to create two classes of mutants: actin-resistant variants, which still catalyze DNA hydrolysis but are no longer inhibited by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e2dd1ec3d817151e4814df4643e6a2
https://europepmc.org/articles/PMC38651/
https://europepmc.org/articles/PMC38651/