Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Vishwanath R. Lingappa"'
Autor:
Jonathan C. Reed, Kent Matlack, Daryl J. Phuong, J. Victor Swain, Clarence R. Hurt, Beverly Freeman, Jaisri R. Lingappa, Dennis Solas, Dylan T. B. Ressler, Anatoliy Kitaygorodskyy, Vishwanath R. Lingappa
Publikováno v:
Journal of Virology
The success of antiretroviral treatment for HIV-1 is at risk of being undermined by the growing problem of drug resistance. Thus, there is a need to identify antiretrovirals that act on viral life cycle stages not targeted by drugs in use, such as th
Publikováno v:
Proceedings of the National Academy of Sciences. 98:7823-7828
Amino-terminal signal sequences target nascent secretory and membrane proteins to the endoplasmic reticulum for translocation. Subsequent interactions between the signal sequence and components of the translocation machinery at the endoplasmic reticu
Publikováno v:
Journal of Biological Chemistry. 269:7617-7622
Signal, stop transfer, and signal-anchor sequences direct a nascent polypeptide to a single topology with respect to the membrane of the endoplasmic reticulum. However, other types of sequences direct nascent proteins, either transiently or permanent
Autor:
Vishwanath R. Lingappa, M. C. Calayag, Antonio Frigeri, William R. Skach, Lan-Bo Shi, Alan S. Verkman
Publikováno v:
The Journal of Cell Biology
The Journal of cell biology, vol 125, iss 4
The Journal of cell biology, vol 125, iss 4
CHIP28 is a 28-kD hydrophobic integral membrane protein that functions as a water channel in erythrocytes and renal tubule epithelial cell membranes. We examined the transmembrane topology of CHIP28 in the ER by engineering a reporter of translocatio
Publikováno v:
Journal of Biological Chemistry. 268:23552-23561
Transmembrane topology of polytopic integral membrane proteins is established during protein synthesis at the endoplasmic reticulum membrane. For some polytopic proteins, sequential and independent signal, stop transfer, and/or signal anchor sequence
Autor:
S L Chuck, Vishwanath R. Lingappa
Publikováno v:
Journal of Biological Chemistry. 268:22794-22801
In contrast to typical secretory proteins, apolipoprotein B pauses at distinct points along the nascent chain during its translocation into the lumen of the endoplasmic reticulum. Specific pause transfer sequences mediate such discrete pauses in the
Publikováno v:
Nature. 346:382-385
Apolipoprotein B (apo B) is crucial for the transport of cholesterol in humans. It is a large secretory protein that mediates the uptake of low-density lipoproteins and renders several forms of lipid droplets soluble in the blood. The binding of lipi
Publikováno v:
Journal of Virology. 64:1414-1419
The coding region for the hepatitis B virus surface antigens contains three in-phase ATG codons which direct the synthesis of three related polypeptides. The 24-kilodalton major surface (or S) glycoprotein is initiated at the most distal ATG and is a
Publikováno v:
The Mount Sinai journal of medicine, New York. 72(3)
We review the important role that cell-free protein-synthesizing systems (CFPSS) have played in the history of modern biology, and highlight two recent applications that illustrate their continued utility for the exploration of otherwise intractable
Publikováno v:
The Journal of biological chemistry. 278(32)
An interaction between an N-terminal signal sequence and the translocon leads to the initiation of protein translocation into the endoplasmic reticulum lumen. Subsequently, folding and modification of the substrate rapidly ensue. The close temporal c