Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Esteban Nova"'
Publikováno v:
Archives of Biochemistry and Biophysics. 621:46-53
Amyloids are polypeptide aggregates involved in many pathologies including Alzheimer's disease. Amyloid assembly is a complex process affected by different interactions including hydrogen bonding, van der Waals forces and electrostatic interactions.
Autor:
Octavio Monasterio, Rosalba Lagos, Julio Benites, Julien Verrax, Pedro Buc Calderon, Daniel Maturana, Cristian Escobar, Jaime A. Valderrama, Eunices Gutierrez, Esteban Nova, Felipe Villanelo
Publikováno v:
Biochemical and biophysical research communications. 466(3)
Dihydroxynaphthyl aryl ketones 1-5 have been evaluated for their abilities to inhibit microtubule assembly and the binding to tubulin. Compounds 3, 4 and 5 displayed competitive inhibition against colchicine binding, and docking analysis showed that
Publikováno v:
Archives of biochemistry and biophysics. 465(2)
FtsZ (Filamentous temperature sensitivity Z) cell division protein from Escherichia coli binds the fluorescence probe DAPI. Bundling of FtsZ was facilitated in the presence of DAPI, and the polymers in solution remained polymerized longer time than t