Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Yong J. Lee"'
Publikováno v:
British Journal of Pharmacology. 157:1189-1202
Background and purpose: Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) triggers apoptotic death in a variety of cancer cells without marked toxicity to most normal cells. We previously reported that wogonin, a potent anticancer agen
Publikováno v:
Biochemical Pharmacology. 75:2345-2355
The aim of this study was to investigate the effect of quercetin, a flavonoid, on the apoptotic pathway in a human prostate cell line (LNCaP). We observed that treatment of cells for 24h with quercetin-induced cell death in a dose-dependent manner. A
Autor:
Yong J. Lee, Jinsang Yoo
Publikováno v:
Molecular Pharmacology. 72:1586-1592
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising cancer therapeutic agent because of its tumor selectivity. TRAIL is known to induce apoptosis in cancer cells but spare most normal cells. In this study, we examined wheth
Autor:
Yong J. Lee, Seok Joon Kwon
Publikováno v:
Clinical Cancer Research. 11:4694-4700
Purpose and Experimental Design: Tumor microenvironment is characterized by regions of fluctuating and chronic hypoxia, low extracellular pH, and nutrient depletion. Although it is well known that hypoxia stimulates the accumulation of hypoxia-induci
Autor:
Jedrzej Antosiewicz, Yan Zeng, Sanjay K. Srivastava, Karen L. Lew, Hui Xiao, Yong J. Lee, Dong Xiao, Simon C. Watkins, Anna Herman-Antosiewicz, Shivendra V. Singh, Donald L. Trump, Candace S. Johnson, Sunga Choi
Publikováno v:
Journal of Biological Chemistry. 280:19911-19924
We have shown previously that sulforaphane (SFN), a constituent of many edible cruciferous vegetables including broccoli, suppresses growth of prostate cancer cells in culture as well as in vivo by causing apoptosis, but the sequence of events leadin
Autor:
Ki M. Kim, Yong J. Lee
Publikováno v:
Oncogene. 24:355-366
We have previously shown that low extracellular pH (pHe) promotes cell killing by the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). In this study, we examined whether amiloride, an inhibitor of the Na(+)/H(+) antiporter capable of
Autor:
Jae J. Song, Yong J. Lee
Publikováno v:
Journal of Biological Chemistry. 279:30573-30578
The cellular target responsible for the nuclear export of Daxx has been identified as chromosomal region maintenance 1 (CRM1), which is a carrier protein for nuclear export and a receptor for the nuclear export signal (NES) of Daxx. Binding of Daxx t
Autor:
Shivendra V. Singh, Victor G. Vogel, Sunga Choi, Dong Xiao, Yong J. Lee, Daniel Johnson, Candace S. Johnson, Donald L. Trump
Publikováno v:
Oncogene. 23:5594-5606
Garlic-derived organosulfides (OSCs) including diallyl trisulfide (DATS) are highly effective in affording protection against chemically induced cancer in animals. Evidence is also mounting to indicate that some naturally occurring OSCs can suppress
Autor:
Yong J. Lee, Jae J. Song
Publikováno v:
Journal of Cellular Biochemistry. 89:653-662
Recently, acute total glucose deprivation has been shown to cause activation of ASK1-MEK-MAPK signal transduction and dissociation of glutaredoxin (GRX) from apoptosis signal-regulating kinase 1 (ASK1). In this study, we investigated whether clinical
Autor:
Eliot M. Rosen, Jeong-Keun Rih, Chi-Heum Cho, Kye-Im Jeon, Hee Jeong Kim, Itzhak D. Goldberg, Yong J. Lee, Insoo Bae
Publikováno v:
FEBS Letters. 544:246-251
Prostate cancer is one of the most common cancers in men and is the second leading cause of cancer-related deaths in the USA. Many anti-tumor agents against prostate cancer cells have been developed, but their unacceptable systemic toxicity to normal