Zobrazeno 1 - 10
of 269
pro vyhledávání: '"Angelo M. De Marzo"'
Autor:
Joakin O. Mori, Elizabeth A. Platz, Jiayun Lu, Alexandria Brame, Misop Han, Corinne E. Joshu, Angelo M. De Marzo, Alan K. Meeker, Christopher M. Heaphy
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
BackgroundTelomeres are located at chromosomal termini and function to maintain genomic integrity. Telomere dysfunction is a well-recognized contributor to aging and age-related diseases, such as prostate cancer. Since telomere length is highly herit
Externí odkaz:
https://doaj.org/article/320c4606921c4c48b2696c1f46557873
Autor:
Tesa M. Severson, Yanyun Zhu, Angelo M. De Marzo, Tracy Jones, Jonathan W. Simons, William G. Nelson, Srinivasan Yegnasubramanian, Matthew L. Freedman, Lodewyk Wessels, Andries M. Bergman, Michael C. Haffner, Wilbert Zwart
Publikováno v:
Molecular Oncology, Vol 15, Iss 7, Pp 1942-1955 (2021)
The epigenomic regulation of transcriptional programs in metastatic prostate cancer is poorly understood. We studied the epigenomic landscape of prostate cancer drivers using transcriptional profiling and ChIP‐seq in four clonal metastatic tumors d
Externí odkaz:
https://doaj.org/article/56b5db94e7bb424f9f026fc02defd139
Autor:
Samuel R. Denmeade, Laura A. Sena, Jun Luo, Mark C. Markowski, Angelo M. De Marzo, Sushant Kachhap, Emmanuel S. Antonarakis
Publikováno v:
Clin Genitourin Cancer
Bipolar androgen therapy (BAT) is a novel treatment strategy for patients with metastatic castration-resistant prostate cancer (mCRPC). We retrospectively identified patients with mCRPC that achieved deep PSA responses to BAT. All patients with avail
Autor:
Erickson A, Carlos S. Moreno, Michelle M. Kouspou, Fred Saad, Michael S. Lewis, Onur Ertunc, Adeboye O. Osunkoya, Colm Morrissey, Bigler Sa, Tuomas Mirtti, Anne-Marie Mes-Masson, Stephen J. Freedland, Zhou X, Igor Vidal, Aud Svindland, Larry True, Tracy Jones, Ouellet, Mark Buzza, Wiley K, Tasken Ka, Pekka Taimen, Isla P. Garraway, Ariel H Achtman, Bova Sg, Angelo M. De Marzo, Bruce J. Trock, Dominique Trudel, Berge, Tarja Lamminen, Beatrice S. Knudsen
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 31:715-727
Background: The need to better understand the molecular underpinnings of the heterogeneous outcomes of patients with prostate cancer is a pressing global problem and a key research priority for Movember. To address this, the Movember Global Action Pl
Autor:
Srinivasan Yegnasubramanian, Jonathan W. Simons, William G. Nelson, Michael C. Haffner, Andries M. Bergman, Lodewyk F. A. Wessels, Tesa M. Severson, Matthew L. Freedman, Wilbert Zwart, Tracy Jones, Yanyun Zhu, Angelo M. De Marzo
Publikováno v:
Molecular Oncology, Vol 15, Iss 7, Pp 1942-1955 (2021)
Molecular Oncology
Molecular Oncology, 15(7), 1942-1955. Elsevier
Molecular Oncology
Molecular Oncology, 15(7), 1942-1955. Elsevier
The epigenomic regulation of transcriptional programs in metastatic prostate cancer is poorly understood. We studied the epigenomic landscape of prostate cancer drivers using transcriptional profiling and ChIP‐seq in four clonal metastatic tumors d
Autor:
Zhongyuan Zhang, W. Nathaniel Brennen, Angelo M. De Marzo, Alexandria Brame, Levent Trabzonlu, Sarah R. Amend, Denis Wirtz, Timothy E. G. Krueger, Ashley Kiemen, Amber E. de Groot, Kayla V. Myers, Kenneth J. Pienta, Vicente E Torres, Natalia H Nagy
Publikováno v:
Prostate
Background Tumor-associated macrophages (TAMs) are critical components of the tumor microenvironment (TME) in prostate cancer. Commonly used orthotopic models do not accurately reflect the complete TME of a human patient or the natural initiation and
Autor:
Lorelei A. Mucci, Alan K. Meeker, Edward Giovannucci, Meir J. Stampfer, Reza Zarinshenas, Angelo M. De Marzo, Elizabeth A. Platz, Misop Han, Tamara L. Lotan, Christine Davis, Corinne E. Joshu, Jiayun Lu, John R. Barber, Christopher M. Heaphy
Publikováno v:
The journal of pathology. Clinical research. 8(5)
PurposeCurrent biomarkers are inadequate prognostic predictors in localized prostate cancer making treatment decision-making challenging. Previously, we observed that the combination of more variable telomere length among prostate cancer cells and sh
Autor:
Srinivasan Yegnasubramanian, Janis M. Taube, Angelo M. De Marzo, Busra Ozbek, Carolina Gomes Alexandre, Onur Ertunc, Tracy Jones, Andrew Erickson, Jessica L. Hicks, Karen S. Sfanos, Gunes Guner, Igor Vidal
Background Most prostate cancers are "immune cold" and poorly responsive to immune checkpoint inhibitors. However, the mechanisms responsible for the lack of a robust antitumor adaptive immune response in the prostate are poorly understood, which hin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c591f71687247183a020de67df431d23
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/96552
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/96552
Autor:
William G. Nelson, Phyllis J. Goodman, Susan Chadid, Xiaoling Song, Bora Gurel, Scott M. Lippman, Ian M. Thompson, Howard L. Parnes, Elizabeth A. Platz, Jeannette M. Schenk, M. Scott Lucia, Marian L. Neuhouser, Angelo M. De Marzo
Publikováno v:
Nutr Cancer
Non-supplemental carotenoids and retinol may potentiate antioxidant and anti-inflammatory mechanisms. Chronic intraprostatic inflammation is linked to prostate carcinogenesis. We investigated the association of circulating carotenoids and retinol wit
Autor:
William G. Nelson, Jonathan I. Epstein, Martine Roudier, Michael C. Haffner, Srinivasan Yegnasubramanian, Lawrence D. True, Peter S. Nelson, Wilbert Zwart, Angelo M. De Marzo
Publikováno v:
Nat Rev Urol
From a clinical, morphological and molecular perspective, prostate cancer is a heterogeneous disease. Primary prostate cancers are often multifocal, having topographically and morphologically distinct tumour foci. Sequencing studies have revealed tha