Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Evan R. Simpson"'
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 145:179-186
Aromatase is the critical enzyme that converts androgens to estrogens. It is frequently highly expressed in the tumour bearing breast of women diagnosed with estrogen receptor positive tumours, resulting in dramatically increased local estrogen produ
Publikováno v:
Hormones and Cancer. 4:233-241
The dramatically increased prevalence of breast cancer after menopause is of great concern and is correlated with elevated local levels of estrogens. This is mainly due to an increase in aromatase expression driven by its proximal promoter II (PII).
Autor:
Isabel Tapia-Páez, J. Bruce Tomblin, Marco Zucchelli, Sudha K. Iyengar, Johannes Schumacher, Shelley D. Smith, Jaana Nopola-Hemmi, Markus M. Nöthen, Xiaotang Fan, Barbara A. Lewis, Jason Spencer, Bruce F. Pennington, Jeffrey W. Gilger, Per Hoffmann, Heidi Anthoni, Gerd Schulte-Körne, Catherine M. Stein, Davor Stanic, Sari Mäkelä, Marie-Estelle Hokkanen, Richard K. Olson, Evan R. Simpson, Mikko Taipale, George W. Hynd, Jan-Åke Gustafsson, Juha Kere, Heikki Lyytinen, Myriam Peyrard-Janvid, Wah Chin Boon, Bertram Müller-Myhsok, Eero Castrén, Jacqueline Schoumans, Magnus Nordenskjöld, Paavo H.T. Leppänen, Lara Sucheston
Publikováno v:
Behavior Genetics
Inspired by the localization, on 15q21.2 of the CYP19A1 gene in the linkage region of speech and language disorders, and a rare translocation in a dyslexic individual that was brought to our attention, we conducted a series of studies on the properti
Publikováno v:
Transgenic Research. 21:415-428
Aromatase converts androgens to estrogens and it is expressed in gonads and non-reproductive tissues (e.g. brain and adipose tissues). As circulating levels of estrogens in males are low, we hypothesize that local estrogen production is important for
Publikováno v:
Breast Cancer Research and Treatment. 123:591-596
AMP-activated protein kinase (AMPK) is recognized as a master regulator of energy homeostasis. In concert with the AMPK-kinase LKB1, it has been shown to provide a molecular link between obesity and postmenopausal breast cancer via its actions to inh
Publikováno v:
Cancer research. 75(4)
Obesity is a risk factor for postmenopausal breast cancer and the majority of these cancers are estrogen dependent. Aromatase converts androgens into estrogens and its increased expression in breast adipose stromal cells (ASC) is a major driver of es
Autor:
Kristy A. Brown, Kazuhiko Nakabayashi, Shigeyuki Ohtsu, Shuji Abe, Martin Wabitsch, Serdar E. Bulun, Heike Vollbach, Tsutomu Ogata, Evan R. Simpson, Maki Fukami, Takayoshi Tsuchiya, Makio Shozu, Henry G. Burger, Daizou Shihara, Akihiro Umezawa
Context:Genomic rearrangements at 15q21 have been shown to cause overexpression of CYP19A1 and resultant aromatase excess syndrome (AEXS). However, mutation spectrum, clinical consequences, and underlying mechanisms of these rearrangements remain to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98597f2d4d85250e7f770f7529d3b3ea
https://europepmc.org/articles/PMC5399493/
https://europepmc.org/articles/PMC5399493/
Autor:
Evan R. Simpson, Zheng Liu
Publikováno v:
Molecular and Cellular Endocrinology. 153:183-196
Bovine cholesterol side-chain cleavage cytochrome P450 (P450scc; product of the CYP11A gene) gene expression is regulated by gonadotropins via cAMP in the ovary, and by ACTH via cAMP in adrenal cortical cells. Previously, we characterized response el
Publikováno v:
Seminars in Reproductive Medicine. 17:0349-0358
Cessation of ovarian estrogen secretion is the key event during the climacteric. An enzyme termed aromatase in a number of human tissues and cells, including ovarian granulosa cells, the placental syncytiotrophoblast, adipose and skin fibroblasts, bo
Publikováno v:
Endocrinology. 139:1610-1617
The expression of aromatase is regulated in a tissue-specific fashion through alternative use of multiple promoter-specific first exons. To date, eight different first exons have been reported in human aromatase, namely I.1., I.2, I.3. I.4, I.5, PII,