Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Baogong Zhu"'
Autor:
Kathleen M. Mahoney, Seth Maleri, Gordon J. Freeman, Vikram R. Juneja, Xia Bu, Carol Reynolds, Kathleen A. McGuire, Philippe Armand, Jerome Ritz, Sarah R. Klein, Edward A. Greenfield, Ping Hua, Baogong Zhu, Melissa T. Bu, Arlene H. Sharpe
Publikováno v:
Cancer Immunol Res
PD-1 expression marks activated T cells susceptible to PD-1–mediated inhibition but not whether a PD-1–mediated signal is being delivered. Molecular predictors of response to PD-1 immune checkpoint blockade (ICB) are needed. We describe a monoclo
Autor:
Apoorvi, Chaudhri, Yanping, Xiao, Alyssa N, Klee, Xiaoxu, Wang, Baogong, Zhu, Gordon J, Freeman
Publikováno v:
Cancer Immunol Res
Programmed death ligand 1 (PD-L1)–mediated immune suppression regulates peripheral tolerance and is often co-opted by tumors to evade immune attack. PD-L1 binds to PD-1 but also binds to B7–1 (CD80) to regulate T-cell function. The binding intera
Autor:
Dana L. Hasselschwert, Arlene H. Sharpe, William C. Satterfield, Arash Grakoui, Benoit Callendret, Charles M. Rice, Michael J. Fuller, Lynn B. Dustin, Baogong Zhu, Rafi Ahmed, Christopher M. Walker, Gordon J. Freeman
Publikováno v:
Proceedings of the National Academy of Sciences. 110:15001-15006
Hepatitis C virus (HCV) persistence is facilitated by exhaustion of CD8+ T cells that express the inhibitory receptor programmed cell death 1 (PD-1). Blockade of PD-1 signaling improves in vitro proliferation of HCV-specific T lymphocytes, but whethe
Autor:
Brett Baker, Elizabeth W Mackey, Florencia Pereyra, Michael T. Waring, Mark A. Brockman, Daniel G. Kavanagh, Eric S. Rosenberg, Toshiyuki Miura, Kristin Moss, Ryan Ahern, Anthony D. Kelleher, Baogong Zhu, Sarah Palmer, Gordon J. Freeman, Daniel Kaufmann, Sylvie Le Gall, Almas Rathod, John Zaunders, Alicja Piechocka-Trocha, John M. Coffin, Bruce D. Walker
Publikováno v:
Nature Immunology. 8:1246-1254
In progressive viral infection, antiviral T cell function is impaired by poorly understood mechanisms. Here we report that the inhibitory immunoregulatory receptor CTLA-4 was selectively upregulated in human immunodeficiency virus (HIV)-specific CD4(
Autor:
David Masopust, James P. Allison, Rafi Ahmed, Gordon J. Freeman, Baogong Zhu, Daniel L. Barber, Arlene H. Sharpe, E. John Wherry
Publikováno v:
Nature. 439:682-687
Functional impairment of antigen-specific T cells is a defining characteristic of many chronic infections, but the underlying mechanisms of T-cell dysfunction are not well understood. To address this question, we analysed genes expressed in functiona
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
Autor:
Baogong Zhu, Jaikumar Duraiswamy, Quentin Eichbaum, Chantal DePierres, Philip J. R. Goulder, Gordon J. Freeman, Alasdair Leslie, Elizabeth W Mackey, Sharon Reddy, Zenele Mncube, Bruce D. Walker, Julia A. Brown, Marcus Altfeld, E. John Wherry, Paul Klenerman, Joseph D. Miller, Eshia Moodley, Hoosen M. Coovadia, Daniel Kaufmann, Rafi Ahmed, Photini Kiepiela, Cheryl L. Day
Publikováno v:
Nature. 443(7109)
Functional impairment of T cells is characteristic of many chronic mouse and human viral infections. The inhibitory receptor programmed death 1 (PD-1; also known as PDCD1), a negative regulator of activated T cells, is markedly upregulated on the sur