Zobrazeno 1 - 10
of 30
pro vyhledávání: '"John L. Brash"'
Publikováno v:
Journal of Biomaterials Science, Polymer Edition. 24:497-506
Measurements of platelet adhesion and fibrinogen adsorption from flowing whole blood to a series of polyethylene oxide (PEO)-based materials were carried out. A unique experimental design was used in which both quantities were measured in the same ex
Publikováno v:
Journal of Biomaterials Science, Polymer Edition. 23:1981-1993
In previous work using gold as a model substrate, we showed that modification of surfaces with poly(ethylene glycol) (PEG) and corn trypsin inhibitor (CTI) rendered them protein resistant and inhibitory against activated factor XII. Sequential attach
Publikováno v:
Langmuir : the ACS journal of surfaces and colloids. 31(44)
The lipoproteins (HDL, LDL, VLDL) are important components of blood present in high concentration. Surprisingly, their role in blood-biomaterial interactions has been largely ignored. In previous work apolipoprotein AI (the main protein component of
Publikováno v:
Langmuir. 28:2099-2106
Polyurethane (PU) was modified using isocyanate chemistry to graft polyethylene oxide (PEO) of various molecular weights (range 300-4600). An antithrombin-heparin (ATH) covalent complex was subsequently attached to the free PEO chain ends, which had
Publikováno v:
Acta Biomaterialia. 7:1993-1998
With the aim of minimizing thrombus formation in blood-contacting devices, tissue plasminogen activator (t-PA)-containing polyurethane (PU) materials have been developed. Cationic PU surfaces were prepared by grafting poly(dimethylaminoethyl methacry
Publikováno v:
Acta Biomaterialia. 7:954-958
We have developed a potentially fibrinolytic surface in which a bioinert polymer is used as a spacer to immobilize lysine such that the ε-amino group is free to capture plasminogen when in contact with blood. Adsorbed plasminogen can be activated to
Publikováno v:
Journal of Biomedical Materials Research Part A. :1223-1232
Protein-resistant polyurethane (PU) surfaces were prepared by sequentially grafting poly(2-hydroxyethyl methacrylate) (poly(HEMA)) and poly(oligo(ethylene glycol) methacrylate) (poly(OEGMA)) via surface-initiated atom transfer radical polymerization
Publikováno v:
Journal of Biomedical Materials Research Part A. :940-946
The objective of this work is to develop a blood contacting surface that possesses both resistance to nonspecific protein adsorption and clot lysing properties. Chemical modification of a polyurethane (PU) surface with poly(ethylene glycol) (PEG); an
Publikováno v:
Acta Biomaterialia. 5:1864-1871
Fibrinolytic polyurethane surfaces were prepared by conjugating lysine to the distal terminus of surface-grafted poly(ethylene glycol) (PEG). Conjugation was through the α-amino group leaving the e-amino group free. Lysine in this form is expected t
Publikováno v:
Journal of Biomedical Materials Research Part A. :178-185
A polyetherurethane (PU) was modified using fluorinated surface-modifying macromolecules (SMMs). A double radiolabel method was used simultaneously to measure the number of adhered platelets (51Cr) and the quantity of adsorbed Fg (125I), in a cone-an