Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Silke Schmidt"'
Autor:
D. A. S. Compston, J. L. Haines, Lisa F. Barcellos, Stephen L. Hauser, Margaret A. Pericak-Vance, Patricia P. Ramsay, Stacy J. Caillier, Jorge R. Oksenberg, Silke Schmidt, Stephen Sawcer, Pablo Gabatto
Publikováno v:
Genes & Immunity. 9:493-500
Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system with a strong genetic component. Variation in the major histocompatibility complex on chromosome 6p21, specifically the HLA-DRB1*15 haplotype, is the strongest g
Autor:
Michael A. Hauser, William K. Scott, Lana M. Olson, Anita Agarwal, Silke Schmidt, Kylee L. Spencer, Eric A. Postel, Paul Gallins, Jonathan L. Haines, Margaret A. Pericak-Vance
Publikováno v:
Human Molecular Genetics. 17:971-977
Age-related macular degeneration (AMD) impairs vision for approximately 7.5 million Americans. Both susceptibility variants and protective haplotypes in the complement factor H (CFH) gene modulate risk for AMD. Recently, deletion of the 'CFH-related'
Autor:
Jonathan L. Haines, Eric A. Postel, John R. Gilbert, Paul Gallins, Silke Schmidt, Nathalie Schnetz-Boutaud, Michael A. Hauser, Kylee L. Spencer, Margaret A. Pericak-Vance, William K. Scott, Anita Agarwal
Publikováno v:
Ophthalmology. 114:1151-1156
Objective To examine the potential gene–environment interaction between cigarette smoking and the complement factor H (CFH) T1277C polymorphism, 2 strong risk factors for age-related macular degeneration (AMD). Design Retrospective case–control s
Autor:
Eric A. Postel, Jonathan L. Haines, Paul Gallins, Silke Schmidt, Margaret A. Pericak-Vance, Cynthia A. Toth, Michael A. Hauser, Jennifer Caldwell, William K. Scott, Anita Agarwal
Publikováno v:
Ophthalmology. 113:1504-1507
Objective To determine if the complement factor H gene ( CFH ) determines risk for development of geographic atrophy (GA). Design Retrospective case–control study. Participants and Controls The independent case–control data set contained 647 age-
Autor:
Marylyn D. Ritchie, Alison A. Motsinger, Lori Steiner, Jorge R. Oksenberg, Stacy J. Caillier, Henry A. Erlich, Silke Schmidt, Simon G. Gregory, Bruce A.C. Cree, Margaret A. Pericak-Vance, David Brassat, J. L. Haines, Lisa F. Barcellos, Karen Walker, Stephen L. Hauser
Publikováno v:
Genes & Immunity. 7:310-315
Multiple sclerosis (MS) is a common disease of the central nervous system characterized by inflammation, myelin loss, gliosis, varying degrees of axonal pathology, and progressive neurological dysfunction. Multiple sclerosis exhibits many of the char
Autor:
Silke Schmidt, Lisa F. Barcellos, Karen DeSombre, Jacqueline B. Rimmler, Robin R. Lincoln, Patricia Bucher, Ann M. Saunders, Eric Lai, Eden R. Martin, Jeffery M. Vance, Jorge R. Oksenberg, Stephen L. Hauser, Margaret A. Pericak-Vance, Jonathan L. Haines, null Multiple Sclerosis Genetics Group
Publikováno v:
The American Journal of Human Genetics. 70:708-717
Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system, with a complex etiology that includes a strong genetic component. The contribution of the major histocompatibility complex (MHC) has been established in numerou
Autor:
Michael A. Hauser, Stephen K. Van Den Eeden, Jason Gibson, Daniela L. Grasso, Freya Kamel, Yutao Liu, Carol Haynes, Eugene Z. Oddone, Annjanette Stone, Lydia Coulter Kwee, Merit Cudkowicz, Sumitra Muralidhar, Silke Schmidt, Robert Lawson, Steven A. Schichman, Caroline M. Tanner, Lorene M. Nelson, Barbara Topol
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 3, p e32768 (2012)
PloS one, vol 7, iss 3
PLoS ONE, Vol 7, Iss 3, p e32768 (2012)
PloS one, vol 7, iss 3
Following reports of an increased incidence of amyotrophic lateral sclerosis (ALS) in U.S. veterans, we have conducted a high-density genome-wide association study (GWAS) of ALS outcome and survival time in a sample of U.S. veterans. We tested ∼1.3
Autor:
Khaled K, Abu-Amero, Essam A, Osman, Ahmed S, Dewedar, Silke, Schmidt, R Rand, Allingham, Saleh A, Al-Obeidan
Publikováno v:
Molecular Vision
Purpose To investigate whether single nucleotide polymorphisms (SNPs) in the lysyl oxidase-like 1 (LOXL1) gene are associated with pseudoexfoliation glaucoma (PEG) in the Saudi Arabian population. Methods The coding regions of LOXL1 were fully sequen
Autor:
Paul Sternberg, Nathalie Schnetz-Boutaud, Jeffrey A. Canter, Eric A. Postel, Brent Anderson, Michael A. Hauser, Lana M. Olson, Margaret A. Pericak-Vance, Jonathan L. Haines, Kylee L. Spencer, Silke Schmidt, Anita Agarwal
Publikováno v:
PLoS ONE, Vol 3, Iss 5, p e2091 (2008)
PLoS ONE
PLoS ONE
The objective of this study was to determine if MTND2*LHON4917G (4917G), a specific non-synonymous polymorphism in the mitochondrial genome previously associated with neurodegenerative phenotypes, is associated with increased risk for age-related mac
Autor:
Yutao, Liu, Silke, Schmidt, Xuejun, Qin, Jason, Gibson, Drew, Munro, Janey L, Wiggs, Michael A, Hauser, R Rand, Allingham
Publikováno v:
Molecular vision. 13
To investigate whether recently described polymorphisms in the optic atrophy 1 gene (OPA1) are associated with primary open-angle glaucoma (POAG) with elevated intraocular pressure in the Caucasian, African-American, and Ghanaian (West African) popul