Zobrazeno 1 - 10
of 32
pro vyhledávání: '"R. Mayeux"'
Autor:
Yang Z; Department of Biostatistics, Columbia University, New York City, NY, USA., Wang C; Department of Biostatistics, Columbia University, New York City, NY, USA.; Division of Nephrology Department of Medicine College of Physicians and Surgeons, Columbia University, New York City, NY, USA., Liu L; Department of Statistics, University of Pittsburgh, Pittsburgh, PA, USA., Khan A; Division of Nephrology Department of Medicine College of Physicians and Surgeons, Columbia University, New York City, NY, USA., Lee A; Department of Neurology College of Physicians and Surgeons, Columbia University, New York City, NY, USA., Vardarajan B; Department of Neurology College of Physicians and Surgeons, Columbia University, New York City, NY, USA., Mayeux R; Department of Neurology College of Physicians and Surgeons, Columbia University, New York City, NY, USA., Kiryluk K; Division of Nephrology Department of Medicine College of Physicians and Surgeons, Columbia University, New York City, NY, USA., Ionita-Laza I; Department of Biostatistics, Columbia University, New York City, NY, USA. ii2135@columbia.edu.
Publikováno v:
Nature genetics [Nat Genet] 2023 Jun; Vol. 55 (6), pp. 1057-1065. Date of Electronic Publication: 2023 May 11.
Autor:
Chung J; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, USA., Das A; Department of Human Genetics, The University of Chicago, Chicago, Illinois, USA., Sun X; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, USA., Sobreira DR; Department of Surgery/Section of Otolaryngology-Head and Neck Surgery, The University of Chicago, Chicago, Illinois, USA., Leung YY; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Igartua C; Department of Human Genetics, The University of Chicago, Chicago, Illinois, USA., Mozaffari S; Department of Human Genetics, The University of Chicago, Chicago, Illinois, USA., Chou YF; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Thiagalingam S; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, USA., Mez J; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA., Zhang X; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, USA., Jun GR; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, USA.; Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Stein TD; Department of Pathology & Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts, USA., Kunkle BW; Dr. John T. Macdonald Foundation of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA., Martin ER; Dr. John T. Macdonald Foundation of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA., Pericak-Vance MA; Dr. John T. Macdonald Foundation of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA., Mayeux R; Department of Neurology, Columbia University, New York City, New York, USA., Haines JL; Department of Population and Quantitative Health Sciences and Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, Ohio, USA., Schellenberg GD; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Nobrega MA; Department of Human Genetics, The University of Chicago, Chicago, Illinois, USA., Lunetta KL; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Pinto JM; Department of Surgery/Section of Otolaryngology-Head and Neck Surgery, The University of Chicago, Chicago, Illinois, USA., Wang LS; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Ober C; Department of Human Genetics, The University of Chicago, Chicago, Illinois, USA., Farrer LA; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, USA.; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.; Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.
Publikováno v:
Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2023 Mar; Vol. 19 (3), pp. 896-908. Date of Electronic Publication: 2022 Jun 30.
Autor:
Ma Y; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts.; Center for Translational & Computational Neuroimmunology, Multiple Sclerosis Clinical Care and Research Center, Division of Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, New York., Jun GR; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts.; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.; Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts., Chung J; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts., Zhang X; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts.; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts., Kunkle BW; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida., Naj AC; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., White CC; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's, Boston, Massachusetts.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois., De Jager PL; Center for Translational & Computational Neuroimmunology, Multiple Sclerosis Clinical Care and Research Center, Division of Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, New York.; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's, Boston, Massachusetts.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts., Mayeux R; Department of Neurology and Sergievsky Center, Columbia University, New York, New York., Haines JL; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio., Pericak-Vance MA; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida., Schellenberg GD; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Farrer LA; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts.; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.; Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts.; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts., Lunetta KL; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.
Publikováno v:
Aging cell [Aging Cell] 2019 Aug; Vol. 18 (4), pp. e12964. Date of Electronic Publication: 2019 May 29.
Autor:
Chung J; Bioinformatics Graduate Program, Boston University, Boston, MA, USA.; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Zhang X; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Allen M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Wang X; Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL, USA., Ma Y; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Beecham G; Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Montine TJ; Department of Pathology, University of Washington, Seattle, WA, USA., Younkin SG; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Golde TE; Center for Translational Research in Neurodegenerative Disease, McKnight Brain Institute, University of Florida, Gainesville, FL, USA., Price ND; Institute for Systems Biology, University of Washington, Seattle, WA, USA., Ertekin-Taner N; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Lunetta KL; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Mez J; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Mayeux R; Department of Neurology and Sergievsky Center, Columbia University, New York, NY, USA., Haines JL; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA., Pericak-Vance MA; Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Schellenberg G; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Jun GR; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.; Neurogenetics and Integrated Genomics, Andover Innovative Medicines Institute, Eisai Inc., Andover, MA, USA., Farrer LA; Bioinformatics Graduate Program, Boston University, Boston, MA, USA. farrer@bu.edu.; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA. farrer@bu.edu.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. farrer@bu.edu.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA. farrer@bu.edu.; Department of Ophthalmology, Boston University School of Medicine, Boston, MA, USA. farrer@bu.edu.; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA. farrer@bu.edu.
Publikováno v:
Alzheimer's research & therapy [Alzheimers Res Ther] 2018 Feb 20; Vol. 10 (1), pp. 22. Date of Electronic Publication: 2018 Feb 20.
Autor:
Sims R; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., van der Lee SJ; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Naj AC; Department of Biostatistics and Epidemiology/Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Bellenguez C; INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; University Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Badarinarayan N; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Jakobsdottir J; Icelandic Heart Association, Kopavogur, Iceland., Kunkle BW; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA., Boland A; CEA/Institut de Génomique, Centre National de Génotypage, Evry, France., Raybould R; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA., Martin ER; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.; Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miami, Florida, USA., Grenier-Boley B; INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; University Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Heilmann-Heimbach S; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany., Chouraki V; Boston University School of Medicine, Boston, Massachusetts, USA.; Framingham Heart Study, Framingham, Massachusetts, USA., Kuzma AB; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Sleegers K; Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium.; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium., Vronskaya M; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Ruiz A; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain., Graham RR; Immunology Biomarkers Group, Genentech, South San Francisco, California, USA., Olaso R; CEA/Institut de Génomique, Centre National de Génotypage, Evry, France., Hoffmann P; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany.; Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, Basel, Switzerland., Grove ML; School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA., Vardarajan BN; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.; Department of Neurology, Columbia University, New York, New York, USA., Hiltunen M; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland., Nöthen MM; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany., White CC; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA., Hamilton-Nelson KL; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA., Epelbaum J; UMR 894, Center for Psychiatry and Neuroscience, INSERM, Université Paris Descartes, Paris, France., Maier W; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Choi SH; Boston University School of Medicine, Boston, Massachusetts, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Beecham GW; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.; Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miami, Florida, USA., Dulary C; CEA/Institut de Génomique, Centre National de Génotypage, Evry, France., Herms S; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany.; Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, Basel, Switzerland., Smith AV; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Funk CC; Institute for Systems Biology, Seattle, Washington, USA., Derbois C; CEA/Institut de Génomique, Centre National de Génotypage, Evry, France., Forstner AJ; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany., Ahmad S; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Li H; Institute for Systems Biology, Seattle, Washington, USA., Bacq D; CEA/Institut de Génomique, Centre National de Génotypage, Evry, France., Harold D; School of Biotechnology, Dublin City University, Dublin, Ireland., Satizabal CL; Boston University School of Medicine, Boston, Massachusetts, USA.; Framingham Heart Study, Framingham, Massachusetts, USA., Valladares O; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Squassina A; Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Thomas R; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA., Qu L; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Sánchez-Juan P; Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IFIMAV), Santander, Spain., Morgan T; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Wolters FJ; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Zhao Y; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Garcia FS; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Denning N; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Fornage M; Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, Texas, USA., Malamon J; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Naranjo MCD; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Majounie E; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Mosley TH; Departments of Medicine, Geriatrics, Gerontology and Neurology, University of Mississippi Medical Center, Jackson, Mississippi, USA., Dombroski B; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Wallon D; Centre Hospitalier du Rouvray, Sotteville les Rouen, France.; INSERM U1079, Rouen University, IRIB, Normandy University, Rouen, France., Lupton MK; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Whitehead P; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA., Fratiglioni L; Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden., Medway C; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Jian X; Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, Texas, USA., Mukherjee S; Department of Medicine, University of Washington, Seattle, Washington, USA., Keller L; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden., Brown K; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Lin H; Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA., Cantwell LB; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Panza F; Neurodegenerative Disease Unit, Department of Basic Medicine, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy., McGuinness B; Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK., Moreno-Grau S; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain., Burgess JD; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA., Solfrizzi V; Geriatric Medicine-Memory Unit and Rare Disease Centre, University of Bari Aldo Moro, Bari, Italy., Proitsi P; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Adams HH; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Allen M; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA., Seripa D; Geriatric Unit and Gerontology-Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy., Pastor P; Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy., Cupples LA; Framingham Heart Study, Framingham, Massachusetts, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Price ND; Institute for Systems Biology, Seattle, Washington, USA., Hannequin D; INSERM U1079, Rouen University, IRIB, Normandy University, Rouen, France.; Department of Neurology, Rouen University Hospital, Rouen, France., Frank-García A; Department of Neurology, University Hospital La Paz, Universidad Autónoma de Madrid, Madrid, Spain.; Instituto de Investigación Sanitaria Hospital la Paz (IdiPAZ), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Levy D; Boston University School of Medicine, Boston, Massachusetts, USA.; Framingham Heart Study, Framingham, Massachusetts, USA.; National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA., Chakrabarty P; Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, Florida, USA., Caffarra P; Department of Neuroscience, University of Parma, Parma, Italy.; Center for Cognitive Disorders AUSL, Parma, Italy., Giegling I; Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany., Beiser AS; Framingham Heart Study, Framingham, Massachusetts, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Giedraitis V; Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden., Hampel H; AXA Research Fund and UPMC Chair, Paris, France.; Sorbonne Universités, Université Pierre et Marie Curie, Paris, France.; Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A) and Institut du Cerveau et de la Moelle Épinière (ICM), Département de Neurologie, Hôpital de la Pitié-Salpêtrière, Paris, France., Garcia ME; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland, USA., Wang X; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA., Lannfelt L; Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden., Mecocci P; Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy., Eiriksdottir G; Icelandic Heart Association, Kopavogur, Iceland., Crane PK; Department of Medicine, University of Washington, Seattle, Washington, USA., Pasquier F; Centre Hospitalier Universitaire de Lille, Epidemiology and Public Health Department, Lille, France.; INSERM UMRS 1171, CNR-Maj, Lille, France., Boccardi V; Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy., Henández I; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain., Barber RC; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA., Scherer M; Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Tarraga L; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain., Adams PM; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Leber M; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany., Chen Y; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Albert MS; Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA., Riedel-Heller S; Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany., Emilsson V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland., Beekly D; National Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, USA., Braae A; Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, UK., Schmidt R; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria., Blacker D; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.; Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA., Masullo C; Department of Neurology, Catholic University of Rome, Rome, Italy., Schmidt H; Institute of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria., Doody RS; Alzheimer's Disease and Memory Disorders Center, Baylor College of Medicine, Houston, Texas, USA., Spalletta G; Experimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy., Longstreth WT Jr; Department of Neurology, University of Washington, Seattle, Washington, USA.; Department of Epidemiology, University of Washington, Seattle, Washington, USA., Fairchild TJ; Office of Strategy and Measurement, University of North Texas Health Science Center, Fort Worth, Texas, USA., Bossù P; Experimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy., Lopez OL; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Frosch MP; C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Charlestown, Massachusetts, USA., Sacchinelli E; Experimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy., Ghetti B; Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana, USA., Yang Q; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Huebinger RM; Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Jessen F; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany., Li S; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Kamboh MI; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Morris J; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.; Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, USA., Sotolongo-Grau O; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain., Katz MJ; Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA., Corcoran C; Department of Mathematics and Statistics, Utah State University, Logan, Utah, USA., Dunstan M; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Braddel A; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Thomas C; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Meggy A; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Marshall R; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Gerrish A; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Chapman J; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Aguilar M; Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain.; Memory Unit, Department of Neurology, Hospital Universitario Mútua Terrassa, Terrassa, Barcelona, Spain., Taylor S; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Hill M; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Fairén MD; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain., Hodges A; Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Vellas B; INSERM U558, University of Toulouse, Toulouse, France., Soininen H; Department of Neurology, Kuopio University Hospital, Kuopio, Finland., Kloszewska I; Elderly and Psychiatric Disorders Department, Medical University of Lodz, Lodz, Poland., Daniilidou M; Department of Health Sciences, Psychiatry for the Elderly, University of Leicester, Leicester, UK., Uphill J; Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK., Patel Y; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Hughes JT; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Lord J; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Turton J; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Hartmann AM; Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany., Cecchetti R; Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy., Fenoglio C; Department of Pathophysiology and Transplantation, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy., Serpente M; Department of Pathophysiology and Transplantation, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy., Arcaro M; Department of Pathophysiology and Transplantation, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy., Caltagirone C; Experimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy., Orfei MD; Experimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy., Ciaramella A; Experimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy., Pichler S; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Mayhaus M; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Gu W; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Lleó A; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain., Fortea J; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain., Blesa R; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain., Barber IS; Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, UK., Brookes K; Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, UK., Cupidi C; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., Maletta RG; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., Carrell D; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA., Sorbi S; NEUROFARBA (Department of Neuroscience, Psychology, Drug Research and Child Health), University of Florence, Florence, Italy.; IRCCS 'Don Carlo Gnocchi', Florence, Italy., Moebus S; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany., Urbano M; Geriatric Unit and Gerontology-Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy., Pilotto A; Geriatric Unit and Gerontology-Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy., Kornhuber J; Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany., Bosco P; Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Associazione Oasi Maria Santissima Srl, Troina, Italy., Todd S; Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK., Craig D; Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK., Johnston J; Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK., Gill M; Mercers Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland., Lawlor B; Mercers Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland., Lynch A; Mercers Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland., Fox NC; Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK., Hardy J; Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK., Albin RL; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.; Geriatric Research, Education and Clinical Center (GRECC), VA Ann Arbor Healthcare System (VAAAHS), Ann Arbor, Michigan, USA.; Michigan Alzheimer Disease Center, Ann Arbor, Michigan, USA., Apostolova LG; Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA.; Department of Neurology, Indiana University, Indianapolis, Indiana, USA.; Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, Indiana, USA., Arnold SE; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Asthana S; Geriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, Wisconsin, USA.; Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, Wisconsin, USA., Atwood CS; Geriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, Wisconsin, USA.; Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, Wisconsin, USA., Baldwin CT; Department of Medicine (Genetics Program), Boston University, Boston, Massachusetts, USA., Barnes LL; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.; Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA., Barral S; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.; Department of Neurology, Columbia University, New York, New York, USA., Beach TG; Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Phoenix, Arizona, USA., Becker JT; Departments of Psychiatry, Neurology, and Psychology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Bigio EH; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Bird TD; Department of Neurology, University of Washington, Seattle, Washington, USA.; VA Puget Sound Health Care System/GRECC, Seattle, Washington, USA., Boeve BF; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA., Bowen JD; Swedish Medical Center, Seattle, Washington, USA., Boxer A; Department of Neurology, University of California, San Francisco, San Francisco, California, USA., Burke JR; Department of Medicine, Duke University, Durham, North Carolina, USA., Burns JM; University of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, Kansas, USA., Buxbaum JD; Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, USA.; Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA.; Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA., Cairns NJ; Department of Pathology and Immunology, Washington University, St. Louis, Missouri, USA., Cao C; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, Florida, USA., Carlson CS; Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Carlsson CM; Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, Wisconsin, USA., Carney RM; Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, USA., Carrasquillo MM; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA., Carroll SL; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Diaz CC; Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, Florida, USA., Chui HC; Department of Neurology, University of Southern California, Los Angeles, California, USA., Clark DG; Department of Neurology, Medical University of South Carolina, Charleston, South Carolina, USA.; Department of Neurology, Ralph H. Johnson VA Medical Center, Charleston, South Carolina, USA., Cribbs DH; Department of Neurology, University of California, Irvine, Irvine, California, USA., Crocco EA; Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, USA., DeCarli C; Department of Neurology, University of California, Davis, Sacramento, California, USA., Dick M; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California, USA., Duara R; Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, Florida, USA., Evans DA; Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA., Faber KM; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA., Fallon KB; Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Fardo DW; Sanders-Brown Center on Aging, Department of Biostatistics, University of Kentucky, Lexington, Kentucky, USA., Farlow MR; Department of Neurology, Indiana University, Indianapolis, Indiana, USA., Ferris S; Department of Psychiatry, New York University, New York, New York, USA., Foroud TM; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA., Galasko DR; Department of Neurosciences, University of California, San Diego, La Jolla, California, USA., Gearing M; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA.; Emory Alzheimer's Disease Center, Emory University, Atlanta, Georgia, USA., Geschwind DH; Neurogenetics Program, University of California, Los Angeles, Los Angeles, California, USA., Gilbert JR; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.; Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miami, Florida, USA., Graff-Radford NR; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.; Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA., Green RC; Division of Genetics, Department of Medicine and Partners Center for Personalized Genetic Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Growdon JH; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA., Hamilton RL; Department of Pathology (Neuropathology), University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Harrell LE; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Honig LS; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA., Huentelman MJ; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA., Hulette CM; Department of Pathology, Duke University, Durham, North Carolina, USA., Hyman BT; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA., Jarvik GP; Department of Genome Sciences, University of Washington, Seattle, Washington, USA.; Department of Medicine (Medical Genetics), University of Washington, Seattle, Washington, USA., Abner E; Sanders-Brown Center on Aging, College of Public Health, Department of Epidemiology, University of Kentucky, Lexington, Kentucky, USA., Jin LW; Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, California, USA., Jun G; Department of Medicine (Genetics Program), Boston University, Boston, Massachusetts, USA.; Department of Biostatistics, Boston University, Boston, Massachusetts, USA.; Department of Ophthalmology, Boston University, Boston, Massachusetts, USA., Karydas A; Department of Neurology, University of California, San Francisco, San Francisco, California, USA., Kaye JA; Department of Neurology, Oregon Health &Science University, Portland, Oregon, USA.; Department of Neurology, Portland Veterans Affairs Medical Center, Portland, Oregon, USA., Kim R; Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, California, USA., Kowall NW; Department of Neurology, Boston University, Boston, Massachusetts, USA.; Department of Pathology, Boston University, Boston, Massachusetts, USA., Kramer JH; Department of Neuropsychology, University of California, San Francisco, San Francisco, California, USA., LaFerla FM; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California, USA., Lah JJ; Department of Neurology, Emory University, Atlanta, Georgia, USA., Leverenz JB; Cleveland Clinic Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, Ohio, USA., Levey AI; Department of Neurology, Emory University, Atlanta, Georgia, USA., Li G; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA.; VA Puget Sound Health Care System/GRECC, Seattle, Washington, USA., Lieberman AP; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA., Lunetta KL; Department of Biostatistics, Boston University, Boston, Massachusetts, USA., Lyketsos CG; Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland, USA., Marson DC; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Martiniuk F; Department of Medicine-Pulmonary, New York University, New York, New York, USA., Mash DC; Department of Neurology, University of Miami, Miami, Florida, USA., Masliah E; Department of Neurosciences, University of California, San Diego, La Jolla, California, USA.; Department of Pathology, University of California, San Diego, La Jolla, California, USA., McCormick WC; Department of Medicine, University of Washington, Seattle, Washington, USA., McCurry SM; School of Nursing Northwest Research Group on Aging, University of Washington, Seattle, Washington, USA., McDavid AN; Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., McKee AC; Department of Neurology, Boston University, Boston, Massachusetts, USA.; Department of Pathology, Boston University, Boston, Massachusetts, USA., Mesulam M; Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Miller BL; Department of Neurology, University of California, San Francisco, San Francisco, California, USA., Miller CA; Department of Pathology, University of Southern California, Los Angeles, California, USA., Miller JW; Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, California, USA., Morris JC; Department of Pathology and Immunology, Washington University, St. Louis, Missouri, USA.; Department of Neurology, Washington University, St. Louis, Missouri, USA., Murrell JR; Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana, USA.; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA., Myers AJ; Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, USA., O'Bryant S; Internal Medicine, Division of Geriatrics, University of North Texas Health Science Center, Fort Worth, Texas, USA., Olichney JM; Department of Neurology, University of California, Davis, Sacramento, California, USA., Pankratz VS; Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA., Parisi JE; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA., Paulson HL; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.; Michigan Alzheimer Disease Center, Ann Arbor, Michigan, USA., Perry W; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA., Peskind E; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA., Pierce A; Department of Neurology, University of California, Irvine, Irvine, California, USA., Poon WW; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California, USA., Potter H; Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA., Quinn JF; Department of Neurology, Oregon Health &Science University, Portland, Oregon, USA.; Department of Neurology, Portland Veterans Affairs Medical Center, Portland, Oregon, USA., Raj A; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, Florida, USA., Raskind M; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA., Reisberg B; Department of Psychiatry, New York University, New York, New York, USA.; Alzheimer's Disease Center, New York University, New York, New York, USA., Reitz C; Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.; Department of Neurology, Columbia University, New York, New York, USA.; Department of Epidemiology, Columbia University, New York, New York, USA., Ringman JM; Department of Neurology, University of California, Los Angeles, Los Angeles, California, USA., Roberson ED; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Rogaeva E; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada., Rosen HJ; Department of Neurology, University of California, San Francisco, San Francisco, California, USA., Rosenberg RN; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Sager MA; Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA., Saykin AJ; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA.; Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, Indiana, USA., Schneider JA; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.; Department of Pathology (Neuropathology), Rush University Medical Center, Chicago, Illinois, USA., Schneider LS; Department of Neurology, University of Southern California, Los Angeles, California, USA.; Department of Psychiatry, University of Southern California, Los Angeles, California, USA., Seeley WW; Department of Neurology, University of California, San Francisco, San Francisco, California, USA., Smith AG; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, Florida, USA., Sonnen JA; Department of Pathology, University of Washington, Seattle, Washington, USA., Spina S; Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana, USA., Stern RA; Department of Neurology, Boston University, Boston, Massachusetts, USA., Swerdlow RH; University of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, Kansas, USA., Tanzi RE; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA., Thornton-Wells TA; Translational Medicine, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA., Trojanowski JQ; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Troncoso JC; Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA., Van Deerlin VM; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Van Eldik LJ; Sanders-Brown Center on Aging, Department of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky, USA., Vinters HV; Department of Neurology, University of California, Los Angeles, Los Angeles, California, USA.; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA., Vonsattel JP; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Pathology, Columbia University, New York, New York, USA., Weintraub S; Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Department of Psychiatry, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Welsh-Bohmer KA; Department of Medicine, Duke University, Durham, North Carolina, USA.; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, USA., Wilhelmsen KC; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Williamson J; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA., Wingo TS; Department of Neurology, Emory University, Atlanta, Georgia, USA., Woltjer RL; Department of Pathology, Oregon Health &Science University, Portland, Oregon, USA., Wright CB; Evelyn F. McKnight Brain Institute, Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, USA., Yu CE; Department of Medicine, University of Washington, Seattle, Washington, USA., Yu L; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA., Garzia F; CEA/Institut de Génomique, Centre National de Génotypage, Evry, France., Golamaully F; CEA/Institut de Génomique, Centre National de Génotypage, Evry, France., Septier G; CEA/Institut de Génomique, Centre National de Génotypage, Evry, France., Engelborghs S; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium., Vandenberghe R; Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium.; Laboratory for Cognitive Neurology, Department of Neurology, University of Leuven, Leuven, Belgium., De Deyn PP; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium., Fernadez CM; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Benito YA; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Thonberg H; Department of Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden.; Department of Neurobiology, Care Sciences and Society, KIADRC, Karolinska Institutet, Stockholm, Sweden., Forsell C; Department of Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden.; Department of Neurobiology, Care Sciences and Society, KIADRC, Karolinska Institutet, Stockholm, Sweden., Lilius L; Department of Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden.; Department of Neurobiology, Care Sciences and Society, KIADRC, Karolinska Institutet, Stockholm, Sweden., Kinhult-Stählbom A; Department of Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden.; Department of Neurobiology, Care Sciences and Society, KIADRC, Karolinska Institutet, Stockholm, Sweden., Kilander L; Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden., Brundin R; Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden., Concari L; Department of Neuroscience, University of Parma, Parma, Italy.; Center for Cognitive Disorders AUSL, Parma, Italy., Helisalmi S; Department of Neurology, Kuopio University Hospital, Kuopio, Finland.; Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland., Koivisto AM; Department of Neurology, Kuopio University Hospital, Kuopio, Finland.; Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland., Haapasalo A; Department of Neurology, Kuopio University Hospital, Kuopio, Finland.; Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland., Dermecourt V; CHU Lille, Memory Center of Lille (Centre Mémoire de Ressources et de Recherche), Lille, France., Fievet N; INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; University Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.; University Paris Descartes, EA 4468, AP-HP, Hôpital Broca, Geriatrics Department, Paris, France., Hanon O; University Paris Descartes, EA 4468, AP-HP, Hôpital Broca, Geriatrics Department, Paris, France., Dufouil C; University of Bordeaux, Neuroepidemiology, Bordeaux, France.; INSERM, Neuroepidemiology, UMR 897, Bordeaux, France., Brice A; INSERM U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.; AP-HP, Department of Genetics, Pitié-Salpêtrière Hospital, Paris, France., Ritchie K; INSERM U1061, La Colombière Hospital, Montpellier, France., Dubois B; Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A), Département de Neurologie, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France.; Institut des Neurosciences Translationnelles de Paris (IHU-A-ICM), Institut du Cerveau et de la Moelle Épinière (ICM), Paris, France.; INSERM, CNRS, UMRS 975, Institut du Cerveau et de la Moelle Épinière (ICM), Paris, France.; Sorbonne Universités, Université Pierre et Marie Curie, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France., Himali JJ; Boston University School of Medicine, Boston, Massachusetts, USA., Keene CD; Department of Pathology, University of Washington, Seattle, Washington, USA., Tschanz J; Department of Mathematics and Statistics, Utah State University, Logan, Utah, USA., Fitzpatrick AL; Department of Epidemiology, University of Washington, Seattle, Washington, USA.; Department of Family Medicine, University of Washington, Seattle, Washington, USA., Kukull WA; Department of Epidemiology, University of Washington, Seattle, Washington, USA., Norton M; Department of Mathematics and Statistics, Utah State University, Logan, Utah, USA., Aspelund T; Icelandic Heart Association, Kopavogur, Iceland.; Centre for Public Health, University of Iceland, Reykjavik, Iceland., Larson EB; Department of Medicine, University of Washington, Seattle, Washington, USA.; Group Health Research Institute, Group Health, Seattle, Washington, USA., Munger R; Department of Mathematics and Statistics, Utah State University, Logan, Utah, USA., Rotter JI; Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA., Lipton RB; Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA., Bullido MJ; Instituto de Investigación Sanitaria Hospital la Paz (IdiPAZ), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain., Hofman A; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Montine TJ; Department of Pathology, University of Washington, Seattle, Washington, USA., Coto E; Molecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain., Boerwinkle E; School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA., Petersen RC; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA., Alvarez V; Molecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain., Rivadeneira F; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.; Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands., Reiman EM; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA.; Arizona Alzheimer's Consortium, Phoenix, Arizona, USA.; Banner Alzheimer's Institute, Phoenix, Arizona, USA.; Department of Psychiatry, University of Arizona, Phoenix, Arizona, USA., Gallo M; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., O'Donnell CJ; Framingham Heart Study, Framingham, Massachusetts, USA., Reisch JS; Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Bruni AC; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., Royall DR; Departments of Psychiatry, Medicine, and Family and Community Medicine and South Texas Veterans Health Administration Geriatric Research Education and Clinical Center (GRECC), University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA., Dichgans M; Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Sano M; Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA., Galimberti D; Department of Pathophysiology and Transplantation, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy., St George-Hyslop P; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada.; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK., Scarpini E; Department of Pathophysiology and Transplantation, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy., Tsuang DW; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA.; VA Puget Sound Health Care System/GRECC, Seattle, Washington, USA., Mancuso M; Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy., Bonuccelli U; Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy., Winslow AR; PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, USA., Daniele A; Institute of Neurology, Catholic University of Sacred Hearth, Rome, Italy., Wu CK; Departments of Neurology, Pharmacology, and Neuroscience, Texas Tech University Health Science Center, Lubbock, Texas, USA., Peters O; Department of Psychiatry, Charité University Medicine, Berlin, Germany., Nacmias B; NEUROFARBA (Department of Neuroscience, Psychology, Drug Research and Child Health), University of Florence, Florence, Italy.; IRCCS 'Don Carlo Gnocchi', Florence, Italy., Riemenschneider M; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Heun R; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Brayne C; Institute of Public Health, University of Cambridge, Cambridge, UK., Rubinsztein DC; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK., Bras J; Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK.; Department of Medical Sciences, Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal., Guerreiro R; Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK.; Department of Medical Sciences, Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal., Al-Chalabi A; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Shaw CE; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Collinge J; Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK., Mann D; Institute of Brain, Behaviour and Mental Health, Clinical and Cognitive Neuroscience Research Group, University of Manchester, Manchester, UK., Tsolaki M; 3rd Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Clarimón J; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain., Sussams R; Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK., Lovestone S; Department of Psychiatry, University of Oxford, Oxford, UK., O'Donovan MC; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Owen MJ; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Behrens TW; Immunology Biomarkers Group, Genentech, South San Francisco, California, USA., Mead S; Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK., Goate AM; Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA., Uitterlinden AG; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.; Department of Pathophysiology and Transplantation, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy., Holmes C; VA Puget Sound Health Care System/GRECC, Seattle, Washington, USA., Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.; Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, USA., Ingelsson M; Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden., Bennett DA; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA., Powell J; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Golde TE; Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, Florida, USA.; Florida Alzheimer's Disease Research Center, Gainesville, Florida, USA., Graff C; Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.; Department of Neurobiology, Care Sciences and Society, KIADRC, Karolinska Institutet, Stockholm, Sweden., De Jager PL; Center for Translational and Systems Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, New York, USA., Morgan K; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Ertekin-Taner N; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.; Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA., Combarros O; Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IFIMAV), Santander, Spain., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Department of Epidemiology, University of Washington, Seattle, Washington, USA.; Department of Health Services, University of Washington, Seattle, Washington, USA., Passmore P; Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK., Younkin SG; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.; Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA., Berr C; Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A), Département de Neurologie, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France.; Memory Research and Resources Center, CMRR of Montpellier, Department of Neurology, Hospital Gui de Chauliac, Montpellier, France.; Department of Neurology, Montpellier University, Montpellier, France., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Rujescu D; Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA., Dartigues JF; Memory Research and Resources Center, CMRR de Bordeaux, Bordeaux, France., DeStefano AL; Framingham Heart Study, Framingham, Massachusetts, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Ortega-Cubero S; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Neurogenetics Laboratory, Division of Neurosciences, Centre for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain.; Department of Neurology, Complejo Asistencial Universitario de Palencia, Palencia, Spain., Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Campion D; Centre Hospitalier du Rouvray, Sotteville les Rouen, France.; INSERM U1079, Rouen University, IRIB, Normandy University, Rouen, France., Boada M; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain., Kauwe JK; Departments of Biology and Neuroscience, Brigham Young University, Provo, Utah, USA., Farrer LA; Boston University School of Medicine, Boston, Massachusetts, USA.; Department of Medicine (Genetics Program), Boston University, Boston, Massachusetts, USA.; Department of Biostatistics, Boston University, Boston, Massachusetts, USA.; Department of Ophthalmology, Boston University, Boston, Massachusetts, USA.; Department of Neurology, Boston University, Boston, Massachusetts, USA., Van Broeckhoven C; Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium.; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium., Ikram MA; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Jones L; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Haines JL; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA., Tzourio C; INSERM U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.; University of Bordeaux, Neuroepidemiology, UMR 897, Bordeaux, France., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland, USA., Escott-Price V; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Mayeux R; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.; Department of Neurology, Columbia University, New York, New York, USA., Deleuze JF; CEA/Institut de Génomique, Centre National de Génotypage, Evry, France., Amin N; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Holmans PA; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Pericak-Vance MA; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.; Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miami, Florida, USA., Amouyel P; INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; University Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.; Centre Hospitalier Universitaire de Lille, Epidemiology and Public Health Department, Lille, France., van Duijn CM; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Ramirez A; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany., Wang LS; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Lambert JC; INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; University Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Seshadri S; Boston University School of Medicine, Boston, Massachusetts, USA.; Framingham Heart Study, Framingham, Massachusetts, USA., Williams J; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Schellenberg GD; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Publikováno v:
Nature genetics [Nat Genet] 2017 Sep; Vol. 49 (9), pp. 1373-1384. Date of Electronic Publication: 2017 Jul 17.
Autor:
Huang KL; Department of Medicine and McDonnell Genome Institute, Washington University in St. Louis, Saint Louis, Missouri, USA., Marcora E; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York,New York, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York,New York, USA., Pimenova AA; Ronald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York,New York, USA., Di Narzo AF; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York,New York, USA., Kapoor M; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York,New York, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York,New York, USA., Jin SC; Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA., Harari O; Department of Psychiatry, Washington University in St. Louis, Saint Louis, Missouri, USA., Bertelsen S; Ronald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York,New York, USA., Fairfax BP; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Czajkowski J; Department of Genetics, Washington University in St. Louis, Saint Louis, Missouri, USA., Chouraki V; Department of Neurology, Boston University School of Medicine, Boston, Massachussets, USA., Grenier-Boley B; Inserm, U1167, RID-AGE -Risk factors and molecular determinants of aging-related diseases, Lille, France.; Univ. Lille - Excellence laboratory Labex DISTALZ, Lille, France.; Institut Pasteur de Lille, Lille, France., Bellenguez C; Inserm, U1167, RID-AGE -Risk factors and molecular determinants of aging-related diseases, Lille, France.; Univ. Lille - Excellence laboratory Labex DISTALZ, Lille, France.; Institut Pasteur de Lille, Lille, France., Deming Y; Department of Psychiatry, Washington University in St. Louis, Saint Louis, Missouri, USA., McKenzie A; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York,New York, USA., Raj T; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York,New York, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York,New York, USA., Renton AE; Ronald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York,New York, USA., Budde J; Department of Psychiatry, Washington University in St. Louis, Saint Louis, Missouri, USA., Smith A; Icelandic Heart Association, Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Fitzpatrick A; Department of Epidemiology, University of Washington, Seattle, Washington, USA., Bis JC; Department of Medicine, University of Washington, Seattle, Washington, USA., DeStefano A; Department of Biostatistics, Boston University School of Public Health, Boston, Massachussetts, USA., Adams HHH; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Ikram MA; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., van der Lee S; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Del-Aguila JL; Department of Psychiatry, Washington University in St. Louis, Saint Louis, Missouri, USA., Fernandez MV; Department of Psychiatry, Washington University in St. Louis, Saint Louis, Missouri, USA., Ibañez L; Department of Psychiatry, Washington University in St. Louis, Saint Louis, Missouri, USA., Sims R; Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Escott-Price V; Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Mayeux R; Taub Institute on Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, and Department of Neurology, Columbia University, New York,New York, USA., Haines JL; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA., Farrer LA; Department of Biostatistics, Boston University School of Public Health, Boston, Massachussetts, USA.; Department of Ophthalmology, Boston University School of Medicine, Boston, Massachussets, USA.; Department of Epidemiology, Boston University School of Public Health, Boston, Massachussetts, USA.; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA., Pericak-Vance MA; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.; Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, USA., Lambert JC; Inserm, U1167, RID-AGE -Risk factors and molecular determinants of aging-related diseases, Lille, France.; Univ. Lille - Excellence laboratory Labex DISTALZ, Lille, France.; Institut Pasteur de Lille, Lille, France., van Duijn C; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Launer L; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland, USA., Seshadri S; Department of Neurology, Boston University School of Medicine, Boston, Massachussets, USA., Williams J; Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Amouyel P; Inserm, U1167, RID-AGE -Risk factors and molecular determinants of aging-related diseases, Lille, France.; Univ. Lille - Excellence laboratory Labex DISTALZ, Lille, France.; Institut Pasteur de Lille, Lille, France.; Centre Hospitalier Universitaire de Lille, U1167, Lille, France., Schellenberg GD; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Zhang B; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York,New York, USA., Borecki I; Department of Genetics, Washington University in St. Louis, Saint Louis, Missouri, USA., Kauwe JSK; Department of Biology, Brigham Young University, Provo, Utah, USA., Cruchaga C; Department of Psychiatry, Washington University in St. Louis, Saint Louis, Missouri, USA., Hao K; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York,New York, USA., Goate AM; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York,New York, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York,New York, USA.
Publikováno v:
Nature neuroscience [Nat Neurosci] 2017 Aug; Vol. 20 (8), pp. 1052-1061. Date of Electronic Publication: 2017 Jun 19.
Autor:
Jun GR; Neurogenetics and Integrated Genomics, Andover Innovative Medicines Institute, Eisai Inc, Andover, MA, USA; Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine, Boston, MA, USA., Chung J; Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine, Boston, MA, USA., Mez J; Department of Neurology, Boston University Schools of Medicine, Boston, MA, USA., Barber R; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA., Beecham GW; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA., Bennett DA; Department of Neurological Sciences and Rush Alzheimer's Disease Center, Chicago, IL, USA., Buxbaum JD; Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA; Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA; Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA., Byrd GS; Department of Biology, North Carolina A&T State University, Greensboro, NC, USA., Carrasquillo MM; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Crane PK; Department of Medicine, University of Washington, Seattle, WA, USA., Cruchaga C; Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St Louis, MO, USA; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA., De Jager P; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Ertekin-Taner N; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Evans D; Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA., Fallin MD; Department of Mental Health, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Foroud TM; Department of Medical & Molecular Genetics, Indiana University, Indianapolis, IN, USA., Friedland RP; Department of Neurology, University of Louisville, Louisville, KY, USA., Goate AM; Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA., Graff-Radford NR; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Hendrie H; Department of Psychiatry, Indiana University, Indianapolis, IN, USA; Regenstrief Institute, Inc, Indianapolis, IN, USA., Hall KS; Regenstrief Institute, Inc, Indianapolis, IN, USA; Department of Medicine, Indiana University, Indianapolis, IN, USA., Hamilton-Nelson KL; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA., Inzelberg R; Department of Neurology and Neurosurgery, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel., Kamboh MI; University of Pittsburgh Alzheimer's Disease Research Center and Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA., Kauwe JSK; Department of Biology, Brigham Young University, Provo, UT, USA., Kukull WA; Department of Epidemiology, University of Washington, Seattle, WA, USA; National Alzheimer's Coordinating Center, University of Washington, Seattle, WA, USA., Kunkle BW; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA., Kuwano R; Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan., Larson EB; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA; Group Health, Group Health Research Institute, Seattle, WA, USA., Logue MW; Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine, Boston, MA, USA; Department of Neurological Sciences and Rush Alzheimer's Disease Center, Chicago, IL, USA; National Center for PTSD, Behavioral Science Division, Boston VA Healthcare System, Boston, MA, USA., Manly JJ; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA., Martin ER; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA., Montine TJ; Department of Pathology, Stanford University, Stanford, CA, USA., Mukherjee S; Department of Medicine, University of Washington, Seattle, WA, USA., Naj A; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Reiman EM; Arizona Alzheimer's Consortium, Phoenix, AZ, USA; Department of Psychiatry, University of Arizona, Phoenix, AZ, USA; Banner Alzheimer's Institute, Phoenix, AZ, USA; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA., Reitz C; The Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Department of Epidemiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA., Sherva R; Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine, Boston, MA, USA., St George-Hyslop PH; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Canada; Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Thornton T; Department of Medicine, University of Washington, Seattle, WA, USA., Younkin SG; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Vardarajan BN; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA., Wang LS; Arizona Alzheimer's Consortium, Phoenix, AZ, USA., Wendlund JR; PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, MA, USA., Winslow AR; PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, MA, USA., Haines J; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA., Mayeux R; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Department of Epidemiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA., Pericak-Vance MA; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA., Schellenberg G; Arizona Alzheimer's Consortium, Phoenix, AZ, USA., Lunetta KL; Department of Biostatistics, Boston University Schools of Public Health, Boston, MA, USA., Farrer LA; Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine, Boston, MA, USA; Department of Neurology, Boston University Schools of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University Schools of Public Health, Boston, MA, USA; Department of Ophthalmology, Boston University Schools of Medicine, Boston, MA, USA; Department of Epidemiology, Boston University Schools of Public Health, Boston, MA, USA. Electronic address: farrer@bu.edu.
Publikováno v:
Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2017 Jul; Vol. 13 (7), pp. 727-738. Date of Electronic Publication: 2017 Feb 07.
Autor:
Desikan RS; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, United States of America., Fan CC; Department of Cognitive Science, University of California, San Diego, La Jolla, California, United States of America., Wang Y; Department of Neurosciences, University of California, San Diego, La Jolla, California, United States of America.; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Schork AJ; Department of Cognitive Science, University of California, San Diego, La Jolla, California, United States of America., Cabral HJ; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America., Cupples LA; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America., Thompson WK; Institute for Biological Psychiatry, Sankt Hans Psychiatric Hospital, Roskilde, Denmark., Besser L; National Alzheimer's Coordinating Center, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America., Kukull WA; National Alzheimer's Coordinating Center, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America., Holland D; Department of Neurosciences, University of California, San Diego, La Jolla, California, United States of America., Chen CH; Department of Radiology, University of California, San Diego, La Jolla, California, United States of America., Brewer JB; Department of Neurosciences, University of California, San Diego, La Jolla, California, United States of America.; Department of Radiology, University of California, San Diego, La Jolla, California, United States of America.; Shiley-Marcos Alzheimer's Disease Research Center, University of California, San Diego, La Jolla, California, United States of America., Karow DS; Department of Radiology, University of California, San Diego, La Jolla, California, United States of America., Kauppi K; Department of Radiology, University of California, San Diego, La Jolla, California, United States of America., Witoelar A; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Karch CM; Department of Psychiatry, Washington University, St. Louis, Missouri, United States of America., Bonham LW; Department of Neurology, University of California, San Francisco, California, United States of America., Yokoyama JS; Department of Neurology, University of California, San Francisco, California, United States of America., Rosen HJ; Department of Neurology, University of California, San Francisco, California, United States of America., Miller BL; Department of Neurology, University of California, San Francisco, California, United States of America., Dillon WP; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, United States of America., Wilson DM; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, United States of America., Hess CP; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, United States of America., Pericak-Vance M; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America., Haines JL; Department of Epidemiology and Biostatistics, Case Western University, Cleveland, Ohio, United States of America.; Institute for Computational Biology, Case Western University, Cleveland, Ohio, United States of America., Farrer LA; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America.; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America.; Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America.; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, United States of America., Mayeux R; Department of Neurology, Columbia University, New York, New York, United States of America.; Taub Institute on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, United States of America.; Gertrude H. Sergievsky Center, Columbia University, New York, New York, United States of America., Hardy J; Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, United Kingdom., Goate AM; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Hyman BT; Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, United States of America., Schellenberg GD; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America., McEvoy LK; Department of Radiology, University of California, San Diego, La Jolla, California, United States of America., Andreassen OA; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Dale AM; Department of Cognitive Science, University of California, San Diego, La Jolla, California, United States of America.; Department of Neurosciences, University of California, San Diego, La Jolla, California, United States of America.; Department of Radiology, University of California, San Diego, La Jolla, California, United States of America.
Publikováno v:
PLoS medicine [PLoS Med] 2017 Mar 21; Vol. 14 (3), pp. e1002258. Date of Electronic Publication: 2017 Mar 21 (Print Publication: 2017).
Autor:
Tosto G; From the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (G.T., J.M., R.O., N.S., Y.S., R.M.), Gertrude H. Sergievsky Center (G.T., J.M., N.S., Y.S., R.M.), and Department of Neurology (G.T., J.M., R.O., N.S., Y.S.), Columbia University College of Physicians and Surgeons, New York; New York Presbyterian Hospital (G.T., J.M., R.O., N.S., Y.S.), NY; Departments of Neurology and Medicine (T.D.B., D.T.), University of Washington, Seattle; Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN; Hope Center for Neurological Disorders (C.C.), Washington University, St Louis, MO; Department of Medical and Molecular Genetics (K.F., T.M.F.), Indiana University; Department of Neurology (M.F.), Indiana University Center for Alzheimer's Disease and Related Disorders, Indianapolis; Department of Neuroscience (A.M.G., S.B.), Mount Sinai School of Medicine, New York, NY; Department of Neurology (N.R.G.-R.), Mayo Clinic, Jacksonville, FL; School of Medicine (M.M., R.M.), Mother and Teacher Pontifical Catholic University, Santiago, Dominican Republic; Department of Medicine (R.L.) and Department of Epidemiology, Mailman School of Public Health (R.O., N.S.), Columbia University, New York; Division of Epidemiology (R.O.), New York State Psychiatric Institute, New York; Department of Neurology and Neurotherapeutics (R.R.), The University of Texas Southwestern Medical Center, Dallas; Department of Health Sciences Research (D.J.S.), Mayo Clinic, Rochester, MN; and Department of Psychiatry, Neurology and Epidemiology (R.A.S.), University of Pittsburgh, PA., Bird TD; From the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (G.T., J.M., R.O., N.S., Y.S., R.M.), Gertrude H. Sergievsky Center (G.T., J.M., N.S., Y.S., R.M.), and Department of Neurology (G.T., J.M., R.O., N.S., Y.S.), Columbia University College of Physicians and Surgeons, New York; New York Presbyterian Hospital (G.T., J.M., R.O., N.S., Y.S.), NY; Departments of Neurology and Medicine (T.D.B., D.T.), University of Washington, Seattle; Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN; Hope Center for Neurological Disorders (C.C.), Washington University, St Louis, MO; Department of Medical and Molecular Genetics (K.F., T.M.F.), Indiana University; Department of Neurology (M.F.), Indiana University Center for Alzheimer's Disease and Related Disorders, Indianapolis; Department of Neuroscience (A.M.G., S.B.), Mount Sinai School of Medicine, New York, NY; Department of Neurology (N.R.G.-R.), Mayo Clinic, Jacksonville, FL; School of Medicine (M.M., R.M.), Mother and Teacher Pontifical Catholic University, Santiago, Dominican Republic; Department of Medicine (R.L.) and Department of Epidemiology, Mailman School of Public Health (R.O., N.S.), Columbia University, New York; Division of Epidemiology (R.O.), New York State Psychiatric Institute, New York; Department of Neurology and Neurotherapeutics (R.R.), The University of Texas Southwestern Medical Center, Dallas; Department of Health Sciences Research (D.J.S.), Mayo Clinic, Rochester, MN; and Department of Psychiatry, Neurology and Epidemiology (R.A.S.), University of Pittsburgh, PA., Tsuang D; From the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (G.T., J.M., R.O., N.S., Y.S., R.M.), Gertrude H. Sergievsky Center (G.T., J.M., N.S., Y.S., R.M.), and Department of Neurology (G.T., J.M., R.O., N.S., Y.S.), Columbia University College of Physicians and Surgeons, New York; New York Presbyterian Hospital (G.T., J.M., R.O., N.S., Y.S.), NY; Departments of Neurology and Medicine (T.D.B., D.T.), University of Washington, Seattle; Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN; Hope Center for Neurological Disorders (C.C.), Washington University, St Louis, MO; Department of Medical and Molecular Genetics (K.F., T.M.F.), Indiana University; Department of Neurology (M.F.), Indiana University Center for Alzheimer's Disease and Related Disorders, Indianapolis; Department of Neuroscience (A.M.G., S.B.), Mount Sinai School of Medicine, New York, NY; Department of Neurology (N.R.G.-R.), Mayo Clinic, Jacksonville, FL; School of Medicine (M.M., R.M.), Mother and Teacher Pontifical Catholic University, Santiago, Dominican Republic; Department of Medicine (R.L.) and Department of Epidemiology, Mailman School of Public Health (R.O., N.S.), Columbia University, New York; Division of Epidemiology (R.O.), New York State Psychiatric Institute, New York; Department of Neurology and Neurotherapeutics (R.R.), The University of Texas Southwestern Medical Center, Dallas; Department of Health Sciences Research (D.J.S.), Mayo Clinic, Rochester, MN; and Department of Psychiatry, Neurology and Epidemiology (R.A.S.), University of Pittsburgh, PA., Bennett DA; From the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (G.T., J.M., R.O., N.S., Y.S., R.M.), Gertrude H. Sergievsky Center (G.T., J.M., N.S., Y.S., R.M.), and Department of Neurology (G.T., J.M., R.O., N.S., Y.S.), Columbia University College of Physicians and Surgeons, New York; New York Presbyterian Hospital (G.T., J.M., R.O., N.S., Y.S.), NY; Departments of Neurology and Medicine (T.D.B., D.T.), University of Washington, Seattle; Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN; Hope Center for Neurological Disorders (C.C.), Washington University, St Louis, MO; Department of Medical and Molecular Genetics (K.F., T.M.F.), Indiana University; Department of Neurology (M.F.), Indiana University Center for Alzheimer's Disease and Related Disorders, Indianapolis; Department of Neuroscience (A.M.G., S.B.), Mount Sinai School of Medicine, New York, NY; Department of Neurology (N.R.G.-R.), Mayo Clinic, Jacksonville, FL; School of Medicine (M.M., R.M.), Mother and Teacher Pontifical Catholic University, Santiago, Dominican Republic; Department of Medicine (R.L.) and Department of Epidemiology, Mailman School of Public Health (R.O., N.S.), Columbia University, New York; Division of Epidemiology (R.O.), New York State Psychiatric Institute, New York; Department of Neurology and Neurotherapeutics (R.R.), The University of Texas Southwestern Medical Center, Dallas; Department of Health Sciences Research (D.J.S.), Mayo Clinic, Rochester, MN; and Department of Psychiatry, Neurology and Epidemiology (R.A.S.), University of Pittsburgh, PA., Boeve BF; From the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (G.T., J.M., R.O., N.S., Y.S., R.M.), Gertrude H. Sergievsky Center (G.T., J.M., N.S., Y.S., R.M.), and Department of Neurology (G.T., J.M., R.O., N.S., Y.S.), Columbia University College of Physicians and Surgeons, New York; New York Presbyterian Hospital (G.T., J.M., R.O., N.S., Y.S.), NY; Departments of Neurology and Medicine (T.D.B., D.T.), University of Washington, Seattle; Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN; Hope Center for Neurological Disorders (C.C.), Washington University, St Louis, MO; Department of Medical and Molecular Genetics (K.F., T.M.F.), Indiana University; Department of Neurology (M.F.), Indiana University Center for Alzheimer's Disease and Related Disorders, Indianapolis; Department of Neuroscience (A.M.G., S.B.), Mount Sinai School of Medicine, New York, NY; Department of Neurology (N.R.G.-R.), Mayo Clinic, Jacksonville, FL; School of Medicine (M.M., R.M.), Mother and Teacher Pontifical Catholic University, Santiago, Dominican Republic; Department of Medicine (R.L.) and Department of Epidemiology, Mailman School of Public Health (R.O., N.S.), Columbia University, New York; Division of Epidemiology (R.O.), New York State Psychiatric Institute, New York; Department of Neurology and Neurotherapeutics (R.R.), The University of Texas Southwestern Medical Center, Dallas; Department of Health Sciences Research (D.J.S.), Mayo Clinic, Rochester, MN; and Department of Psychiatry, Neurology and Epidemiology (R.A.S.), University of Pittsburgh, PA., Cruchaga C; From the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (G.T., J.M., R.O., N.S., Y.S., R.M.), Gertrude H. Sergievsky Center (G.T., J.M., N.S., Y.S., R.M.), and Department of Neurology (G.T., J.M., R.O., N.S., Y.S.), Columbia University College of Physicians and Surgeons, New York; New York Presbyterian Hospital (G.T., J.M., R.O., N.S., Y.S.), NY; Departments of Neurology and Medicine (T.D.B., D.T.), University of Washington, Seattle; Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN; Hope Center for Neurological Disorders (C.C.), Washington University, St Louis, MO; Department of Medical and Molecular Genetics (K.F., T.M.F.), Indiana University; Department of Neurology (M.F.), Indiana University Center for Alzheimer's Disease and Related Disorders, Indianapolis; Department of Neuroscience (A.M.G., S.B.), Mount Sinai School of Medicine, New York, NY; Department of Neurology (N.R.G.-R.), Mayo Clinic, Jacksonville, FL; School of Medicine (M.M., R.M.), Mother and Teacher Pontifical Catholic University, Santiago, Dominican Republic; Department of Medicine (R.L.) and Department of Epidemiology, Mailman School of Public Health (R.O., N.S.), Columbia University, New York; Division of Epidemiology (R.O.), New York State Psychiatric Institute, New York; Department of Neurology and Neurotherapeutics (R.R.), The University of Texas Southwestern Medical Center, Dallas; Department of Health Sciences Research (D.J.S.), Mayo Clinic, Rochester, MN; and Department of Psychiatry, Neurology and Epidemiology (R.A.S.), University of Pittsburgh, PA., Faber K; From the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (G.T., J.M., R.O., N.S., Y.S., R.M.), Gertrude H. Sergievsky Center (G.T., J.M., N.S., Y.S., R.M.), and Department of Neurology (G.T., J.M., R.O., N.S., Y.S.), Columbia University College of Physicians and Surgeons, New York; New York Presbyterian Hospital (G.T., J.M., R.O., N.S., Y.S.), NY; Departments of Neurology and Medicine (T.D.B., D.T.), University of Washington, Seattle; Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN; Hope Center for Neurological Disorders (C.C.), Washington University, St Louis, MO; Department of Medical and Molecular Genetics (K.F., T.M.F.), Indiana University; Department of Neurology (M.F.), Indiana University Center for Alzheimer's Disease and Related Disorders, Indianapolis; Department of Neuroscience (A.M.G., S.B.), Mount Sinai School of Medicine, New York, NY; Department of Neurology (N.R.G.-R.), Mayo Clinic, Jacksonville, FL; School of Medicine (M.M., R.M.), Mother and Teacher Pontifical Catholic University, Santiago, Dominican Republic; Department of Medicine (R.L.) and Department of Epidemiology, Mailman School of Public Health (R.O., N.S.), Columbia University, New York; Division of Epidemiology (R.O.), New York State Psychiatric Institute, New York; Department of Neurology and Neurotherapeutics (R.R.), The University of Texas Southwestern Medical Center, Dallas; Department of Health Sciences Research (D.J.S.), Mayo Clinic, Rochester, MN; and Department of Psychiatry, Neurology and Epidemiology (R.A.S.), University of Pittsburgh, PA., Foroud TM; From the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (G.T., J.M., R.O., N.S., Y.S., R.M.), Gertrude H. Sergievsky Center (G.T., J.M., N.S., Y.S., R.M.), and Department of Neurology (G.T., J.M., R.O., N.S., Y.S.), Columbia University College of Physicians and Surgeons, New York; New York Presbyterian Hospital (G.T., J.M., R.O., N.S., Y.S.), NY; Departments of Neurology and Medicine (T.D.B., D.T.), University of Washington, Seattle; Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN; Hope Center for Neurological Disorders (C.C.), Washington University, St Louis, MO; Department of Medical and Molecular Genetics (K.F., T.M.F.), Indiana University; Department of Neurology (M.F.), Indiana University Center for Alzheimer's Disease and Related Disorders, Indianapolis; Department of Neuroscience (A.M.G., S.B.), Mount Sinai School of Medicine, New York, NY; Department of Neurology (N.R.G.-R.), Mayo Clinic, Jacksonville, FL; School of Medicine (M.M., R.M.), Mother and Teacher Pontifical Catholic University, Santiago, Dominican Republic; Department of Medicine (R.L.) and Department of Epidemiology, Mailman School of Public Health (R.O., N.S.), Columbia University, New York; Division of Epidemiology (R.O.), New York State Psychiatric Institute, New York; Department of Neurology and Neurotherapeutics (R.R.), The University of Texas Southwestern Medical Center, Dallas; Department of Health Sciences Research (D.J.S.), Mayo Clinic, Rochester, MN; and Department of Psychiatry, Neurology and Epidemiology (R.A.S.), University of Pittsburgh, PA., Farlow M; From the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (G.T., J.M., R.O., N.S., Y.S., R.M.), Gertrude H. Sergievsky Center (G.T., J.M., N.S., Y.S., R.M.), and Department of Neurology (G.T., J.M., R.O., N.S., Y.S.), Columbia University College of Physicians and Surgeons, New York; New York Presbyterian Hospital (G.T., J.M., R.O., N.S., Y.S.), NY; Departments of Neurology and Medicine (T.D.B., D.T.), University of Washington, Seattle; Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN; Hope Center for Neurological Disorders (C.C.), Washington University, St Louis, MO; Department of Medical and Molecular Genetics (K.F., T.M.F.), Indiana University; Department of Neurology (M.F.), Indiana University Center for Alzheimer's Disease and Related Disorders, Indianapolis; Department of Neuroscience (A.M.G., S.B.), Mount Sinai School of Medicine, New York, NY; Department of Neurology (N.R.G.-R.), Mayo Clinic, Jacksonville, FL; School of Medicine (M.M., R.M.), Mother and Teacher Pontifical Catholic University, Santiago, Dominican Republic; Department of Medicine (R.L.) and Department of Epidemiology, Mailman School of Public Health (R.O., N.S.), Columbia University, New York; Division of Epidemiology (R.O.), New York State Psychiatric Institute, New York; Department of Neurology and Neurotherapeutics (R.R.), The University of Texas Southwestern Medical Center, Dallas; Department of Health Sciences Research (D.J.S.), Mayo Clinic, Rochester, MN; and Department of Psychiatry, Neurology and Epidemiology (R.A.S.), University of Pittsburgh, PA., Goate AM; From the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (G.T., J.M., R.O., N.S., Y.S., R.M.), Gertrude H. Sergievsky Center (G.T., J.M., N.S., Y.S., R.M.), and Department of Neurology (G.T., J.M., R.O., N.S., Y.S.), Columbia University College of Physicians and Surgeons, New York; New York Presbyterian Hospital (G.T., J.M., R.O., N.S., Y.S.), NY; Departments of Neurology and Medicine (T.D.B., D.T.), University of Washington, Seattle; Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN; Hope Center for Neurological Disorders (C.C.), Washington University, St Louis, MO; Department of Medical and Molecular Genetics (K.F., T.M.F.), Indiana University; Department of Neurology (M.F.), Indiana University Center for Alzheimer's Disease and Related Disorders, Indianapolis; Department of Neuroscience (A.M.G., S.B.), Mount Sinai School of Medicine, New York, NY; Department of Neurology (N.R.G.-R.), Mayo Clinic, Jacksonville, FL; School of Medicine (M.M., R.M.), Mother and Teacher Pontifical Catholic University, Santiago, Dominican Republic; Department of Medicine (R.L.) and Department of Epidemiology, Mailman School of Public Health (R.O., N.S.), Columbia University, New York; Division of Epidemiology (R.O.), New York State Psychiatric Institute, New York; Department of Neurology and Neurotherapeutics (R.R.), The University of Texas Southwestern Medical Center, Dallas; Department of Health Sciences Research (D.J.S.), Mayo Clinic, Rochester, MN; and Department of Psychiatry, Neurology and Epidemiology (R.A.S.), University of Pittsburgh, PA., Bertlesen S; From the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (G.T., J.M., R.O., N.S., Y.S., R.M.), Gertrude H. Sergievsky Center (G.T., J.M., N.S., Y.S., R.M.), and Department of Neurology (G.T., J.M., R.O., N.S., Y.S.), Columbia University College of Physicians and Surgeons, New York; New York Presbyterian Hospital (G.T., J.M., R.O., N.S., Y.S.), NY; Departments of Neurology and Medicine (T.D.B., D.T.), University of Washington, Seattle; Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN; Hope Center for Neurological Disorders (C.C.), Washington University, St Louis, MO; Department of Medical and Molecular Genetics (K.F., T.M.F.), Indiana University; Department of Neurology (M.F.), Indiana University Center for Alzheimer's Disease and Related Disorders, Indianapolis; Department of Neuroscience (A.M.G., S.B.), Mount Sinai School of Medicine, New York, NY; Department of Neurology (N.R.G.-R.), Mayo Clinic, Jacksonville, FL; School of Medicine (M.M., R.M.), Mother and Teacher Pontifical Catholic University, Santiago, Dominican Republic; Department of Medicine (R.L.) and Department of Epidemiology, Mailman School of Public Health (R.O., N.S.), Columbia University, New York; Division of Epidemiology (R.O.), New York State Psychiatric Institute, New York; Department of Neurology and Neurotherapeutics (R.R.), The University of Texas Southwestern Medical Center, Dallas; Department of Health Sciences Research (D.J.S.), Mayo Clinic, Rochester, MN; and Department of Psychiatry, Neurology and Epidemiology (R.A.S.), University of Pittsburgh, PA., Graff-Radford NR; From the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (G.T., J.M., R.O., N.S., Y.S., R.M.), Gertrude H. Sergievsky Center (G.T., J.M., N.S., Y.S., R.M.), and Department of Neurology (G.T., J.M., R.O., N.S., Y.S.), Columbia University College of Physicians and Surgeons, New York; New York Presbyterian Hospital (G.T., J.M., R.O., N.S., Y.S.), NY; Departments of Neurology and Medicine (T.D.B., D.T.), University of Washington, Seattle; Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN; Hope Center for Neurological Disorders (C.C.), Washington University, St Louis, MO; Department of Medical and Molecular Genetics (K.F., T.M.F.), Indiana University; Department of Neurology (M.F.), Indiana University Center for Alzheimer's Disease and Related Disorders, Indianapolis; Department of Neuroscience (A.M.G., S.B.), Mount Sinai School of Medicine, New York, NY; Department of Neurology (N.R.G.-R.), Mayo Clinic, Jacksonville, FL; School of Medicine (M.M., R.M.), Mother and Teacher Pontifical Catholic University, Santiago, Dominican Republic; Department of Medicine (R.L.) and Department of Epidemiology, Mailman School of Public Health (R.O., N.S.), Columbia University, New York; Division of Epidemiology (R.O.), New York State Psychiatric Institute, New York; Department of Neurology and Neurotherapeutics (R.R.), The University of Texas Southwestern Medical Center, Dallas; Department of Health Sciences Research (D.J.S.), Mayo Clinic, Rochester, MN; and Department of Psychiatry, Neurology and Epidemiology (R.A.S.), University of Pittsburgh, PA., Medrano M; From the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (G.T., J.M., R.O., N.S., Y.S., R.M.), Gertrude H. Sergievsky Center (G.T., J.M., N.S., Y.S., R.M.), and Department of Neurology (G.T., J.M., R.O., N.S., Y.S.), Columbia University College of Physicians and Surgeons, New York; New York Presbyterian Hospital (G.T., J.M., R.O., N.S., Y.S.), NY; Departments of Neurology and Medicine (T.D.B., D.T.), University of Washington, Seattle; Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN; Hope Center for Neurological Disorders (C.C.), Washington University, St Louis, MO; Department of Medical and Molecular Genetics (K.F., T.M.F.), Indiana University; Department of Neurology (M.F.), Indiana University Center for Alzheimer's Disease and Related Disorders, Indianapolis; Department of Neuroscience (A.M.G., S.B.), Mount Sinai School of Medicine, New York, NY; Department of Neurology (N.R.G.-R.), Mayo Clinic, Jacksonville, FL; School of Medicine (M.M., R.M.), Mother and Teacher Pontifical Catholic University, Santiago, Dominican Republic; Department of Medicine (R.L.) and Department of Epidemiology, Mailman School of Public Health (R.O., N.S.), Columbia University, New York; Division of Epidemiology (R.O.), New York State Psychiatric Institute, New York; Department of Neurology and Neurotherapeutics (R.R.), The University of Texas Southwestern Medical Center, Dallas; Department of Health Sciences Research (D.J.S.), Mayo Clinic, Rochester, MN; and Department of Psychiatry, Neurology and Epidemiology (R.A.S.), University of Pittsburgh, PA., Lantigua R; From the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (G.T., J.M., R.O., N.S., Y.S., R.M.), Gertrude H. Sergievsky Center (G.T., J.M., N.S., Y.S., R.M.), and Department of Neurology (G.T., J.M., R.O., N.S., Y.S.), Columbia University College of Physicians and Surgeons, New York; New York Presbyterian Hospital (G.T., J.M., R.O., N.S., Y.S.), NY; Departments of Neurology and Medicine (T.D.B., D.T.), University of Washington, Seattle; Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN; Hope Center for Neurological Disorders (C.C.), Washington University, St Louis, MO; Department of Medical and Molecular Genetics (K.F., T.M.F.), Indiana University; Department of Neurology (M.F.), Indiana University Center for Alzheimer's Disease and Related Disorders, Indianapolis; Department of Neuroscience (A.M.G., S.B.), Mount Sinai School of Medicine, New York, NY; Department of Neurology (N.R.G.-R.), Mayo Clinic, Jacksonville, FL; School of Medicine (M.M., R.M.), Mother and Teacher Pontifical Catholic University, Santiago, Dominican Republic; Department of Medicine (R.L.) and Department of Epidemiology, Mailman School of Public Health (R.O., N.S.), Columbia University, New York; Division of Epidemiology (R.O.), New York State Psychiatric Institute, New York; Department of Neurology and Neurotherapeutics (R.R.), The University of Texas Southwestern Medical Center, Dallas; Department of Health Sciences Research (D.J.S.), Mayo Clinic, Rochester, MN; and Department of Psychiatry, Neurology and Epidemiology (R.A.S.), University of Pittsburgh, PA., Manly J; From the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (G.T., J.M., R.O., N.S., Y.S., R.M.), Gertrude H. Sergievsky Center (G.T., J.M., N.S., Y.S., R.M.), and Department of Neurology (G.T., J.M., R.O., N.S., Y.S.), Columbia University College of Physicians and Surgeons, New York; New York Presbyterian Hospital (G.T., J.M., R.O., N.S., Y.S.), NY; Departments of Neurology and Medicine (T.D.B., D.T.), University of Washington, Seattle; Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN; Hope Center for Neurological Disorders (C.C.), Washington University, St Louis, MO; Department of Medical and Molecular Genetics (K.F., T.M.F.), Indiana University; Department of Neurology (M.F.), Indiana University Center for Alzheimer's Disease and Related Disorders, Indianapolis; Department of Neuroscience (A.M.G., S.B.), Mount Sinai School of Medicine, New York, NY; Department of Neurology (N.R.G.-R.), Mayo Clinic, Jacksonville, FL; School of Medicine (M.M., R.M.), Mother and Teacher Pontifical Catholic University, Santiago, Dominican Republic; Department of Medicine (R.L.) and Department of Epidemiology, Mailman School of Public Health (R.O., N.S.), Columbia University, New York; Division of Epidemiology (R.O.), New York State Psychiatric Institute, New York; Department of Neurology and Neurotherapeutics (R.R.), The University of Texas Southwestern Medical Center, Dallas; Department of Health Sciences Research (D.J.S.), Mayo Clinic, Rochester, MN; and Department of Psychiatry, Neurology and Epidemiology (R.A.S.), University of Pittsburgh, PA., Ottman R; From the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (G.T., J.M., R.O., N.S., Y.S., R.M.), Gertrude H. Sergievsky Center (G.T., J.M., N.S., Y.S., R.M.), and Department of Neurology (G.T., J.M., R.O., N.S., Y.S.), Columbia University College of Physicians and Surgeons, New York; New York Presbyterian Hospital (G.T., J.M., R.O., N.S., Y.S.), NY; Departments of Neurology and Medicine (T.D.B., D.T.), University of Washington, Seattle; Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN; Hope Center for Neurological Disorders (C.C.), Washington University, St Louis, MO; Department of Medical and Molecular Genetics (K.F., T.M.F.), Indiana University; Department of Neurology (M.F.), Indiana University Center for Alzheimer's Disease and Related Disorders, Indianapolis; Department of Neuroscience (A.M.G., S.B.), Mount Sinai School of Medicine, New York, NY; Department of Neurology (N.R.G.-R.), Mayo Clinic, Jacksonville, FL; School of Medicine (M.M., R.M.), Mother and Teacher Pontifical Catholic University, Santiago, Dominican Republic; Department of Medicine (R.L.) and Department of Epidemiology, Mailman School of Public Health (R.O., N.S.), Columbia University, New York; Division of Epidemiology (R.O.), New York State Psychiatric Institute, New York; Department of Neurology and Neurotherapeutics (R.R.), The University of Texas Southwestern Medical Center, Dallas; Department of Health Sciences Research (D.J.S.), Mayo Clinic, Rochester, MN; and Department of Psychiatry, Neurology and Epidemiology (R.A.S.), University of Pittsburgh, PA., Rosenberg R; From the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (G.T., J.M., R.O., N.S., Y.S., R.M.), Gertrude H. Sergievsky Center (G.T., J.M., N.S., Y.S., R.M.), and Department of Neurology (G.T., J.M., R.O., N.S., Y.S.), Columbia University College of Physicians and Surgeons, New York; New York Presbyterian Hospital (G.T., J.M., R.O., N.S., Y.S.), NY; Departments of Neurology and Medicine (T.D.B., D.T.), University of Washington, Seattle; Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN; Hope Center for Neurological Disorders (C.C.), Washington University, St Louis, MO; Department of Medical and Molecular Genetics (K.F., T.M.F.), Indiana University; Department of Neurology (M.F.), Indiana University Center for Alzheimer's Disease and Related Disorders, Indianapolis; Department of Neuroscience (A.M.G., S.B.), Mount Sinai School of Medicine, New York, NY; Department of Neurology (N.R.G.-R.), Mayo Clinic, Jacksonville, FL; School of Medicine (M.M., R.M.), Mother and Teacher Pontifical Catholic University, Santiago, Dominican Republic; Department of Medicine (R.L.) and Department of Epidemiology, Mailman School of Public Health (R.O., N.S.), Columbia University, New York; Division of Epidemiology (R.O.), New York State Psychiatric Institute, New York; Department of Neurology and Neurotherapeutics (R.R.), The University of Texas Southwestern Medical Center, Dallas; Department of Health Sciences Research (D.J.S.), Mayo Clinic, Rochester, MN; and Department of Psychiatry, Neurology and Epidemiology (R.A.S.), University of Pittsburgh, PA., Schaid DJ; From the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (G.T., J.M., R.O., N.S., Y.S., R.M.), Gertrude H. Sergievsky Center (G.T., J.M., N.S., Y.S., R.M.), and Department of Neurology (G.T., J.M., R.O., N.S., Y.S.), Columbia University College of Physicians and Surgeons, New York; New York Presbyterian Hospital (G.T., J.M., R.O., N.S., Y.S.), NY; Departments of Neurology and Medicine (T.D.B., D.T.), University of Washington, Seattle; Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN; Hope Center for Neurological Disorders (C.C.), Washington University, St Louis, MO; Department of Medical and Molecular Genetics (K.F., T.M.F.), Indiana University; Department of Neurology (M.F.), Indiana University Center for Alzheimer's Disease and Related Disorders, Indianapolis; Department of Neuroscience (A.M.G., S.B.), Mount Sinai School of Medicine, New York, NY; Department of Neurology (N.R.G.-R.), Mayo Clinic, Jacksonville, FL; School of Medicine (M.M., R.M.), Mother and Teacher Pontifical Catholic University, Santiago, Dominican Republic; Department of Medicine (R.L.) and Department of Epidemiology, Mailman School of Public Health (R.O., N.S.), Columbia University, New York; Division of Epidemiology (R.O.), New York State Psychiatric Institute, New York; Department of Neurology and Neurotherapeutics (R.R.), The University of Texas Southwestern Medical Center, Dallas; Department of Health Sciences Research (D.J.S.), Mayo Clinic, Rochester, MN; and Department of Psychiatry, Neurology and Epidemiology (R.A.S.), University of Pittsburgh, PA., Schupf N; From the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (G.T., J.M., R.O., N.S., Y.S., R.M.), Gertrude H. Sergievsky Center (G.T., J.M., N.S., Y.S., R.M.), and Department of Neurology (G.T., J.M., R.O., N.S., Y.S.), Columbia University College of Physicians and Surgeons, New York; New York Presbyterian Hospital (G.T., J.M., R.O., N.S., Y.S.), NY; Departments of Neurology and Medicine (T.D.B., D.T.), University of Washington, Seattle; Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN; Hope Center for Neurological Disorders (C.C.), Washington University, St Louis, MO; Department of Medical and Molecular Genetics (K.F., T.M.F.), Indiana University; Department of Neurology (M.F.), Indiana University Center for Alzheimer's Disease and Related Disorders, Indianapolis; Department of Neuroscience (A.M.G., S.B.), Mount Sinai School of Medicine, New York, NY; Department of Neurology (N.R.G.-R.), Mayo Clinic, Jacksonville, FL; School of Medicine (M.M., R.M.), Mother and Teacher Pontifical Catholic University, Santiago, Dominican Republic; Department of Medicine (R.L.) and Department of Epidemiology, Mailman School of Public Health (R.O., N.S.), Columbia University, New York; Division of Epidemiology (R.O.), New York State Psychiatric Institute, New York; Department of Neurology and Neurotherapeutics (R.R.), The University of Texas Southwestern Medical Center, Dallas; Department of Health Sciences Research (D.J.S.), Mayo Clinic, Rochester, MN; and Department of Psychiatry, Neurology and Epidemiology (R.A.S.), University of Pittsburgh, PA., Stern Y; From the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (G.T., J.M., R.O., N.S., Y.S., R.M.), Gertrude H. Sergievsky Center (G.T., J.M., N.S., Y.S., R.M.), and Department of Neurology (G.T., J.M., R.O., N.S., Y.S.), Columbia University College of Physicians and Surgeons, New York; New York Presbyterian Hospital (G.T., J.M., R.O., N.S., Y.S.), NY; Departments of Neurology and Medicine (T.D.B., D.T.), University of Washington, Seattle; Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN; Hope Center for Neurological Disorders (C.C.), Washington University, St Louis, MO; Department of Medical and Molecular Genetics (K.F., T.M.F.), Indiana University; Department of Neurology (M.F.), Indiana University Center for Alzheimer's Disease and Related Disorders, Indianapolis; Department of Neuroscience (A.M.G., S.B.), Mount Sinai School of Medicine, New York, NY; Department of Neurology (N.R.G.-R.), Mayo Clinic, Jacksonville, FL; School of Medicine (M.M., R.M.), Mother and Teacher Pontifical Catholic University, Santiago, Dominican Republic; Department of Medicine (R.L.) and Department of Epidemiology, Mailman School of Public Health (R.O., N.S.), Columbia University, New York; Division of Epidemiology (R.O.), New York State Psychiatric Institute, New York; Department of Neurology and Neurotherapeutics (R.R.), The University of Texas Southwestern Medical Center, Dallas; Department of Health Sciences Research (D.J.S.), Mayo Clinic, Rochester, MN; and Department of Psychiatry, Neurology and Epidemiology (R.A.S.), University of Pittsburgh, PA., Sweet RA; From the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (G.T., J.M., R.O., N.S., Y.S., R.M.), Gertrude H. Sergievsky Center (G.T., J.M., N.S., Y.S., R.M.), and Department of Neurology (G.T., J.M., R.O., N.S., Y.S.), Columbia University College of Physicians and Surgeons, New York; New York Presbyterian Hospital (G.T., J.M., R.O., N.S., Y.S.), NY; Departments of Neurology and Medicine (T.D.B., D.T.), University of Washington, Seattle; Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN; Hope Center for Neurological Disorders (C.C.), Washington University, St Louis, MO; Department of Medical and Molecular Genetics (K.F., T.M.F.), Indiana University; Department of Neurology (M.F.), Indiana University Center for Alzheimer's Disease and Related Disorders, Indianapolis; Department of Neuroscience (A.M.G., S.B.), Mount Sinai School of Medicine, New York, NY; Department of Neurology (N.R.G.-R.), Mayo Clinic, Jacksonville, FL; School of Medicine (M.M., R.M.), Mother and Teacher Pontifical Catholic University, Santiago, Dominican Republic; Department of Medicine (R.L.) and Department of Epidemiology, Mailman School of Public Health (R.O., N.S.), Columbia University, New York; Division of Epidemiology (R.O.), New York State Psychiatric Institute, New York; Department of Neurology and Neurotherapeutics (R.R.), The University of Texas Southwestern Medical Center, Dallas; Department of Health Sciences Research (D.J.S.), Mayo Clinic, Rochester, MN; and Department of Psychiatry, Neurology and Epidemiology (R.A.S.), University of Pittsburgh, PA., Mayeux R; From the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (G.T., J.M., R.O., N.S., Y.S., R.M.), Gertrude H. Sergievsky Center (G.T., J.M., N.S., Y.S., R.M.), and Department of Neurology (G.T., J.M., R.O., N.S., Y.S.), Columbia University College of Physicians and Surgeons, New York; New York Presbyterian Hospital (G.T., J.M., R.O., N.S., Y.S.), NY; Departments of Neurology and Medicine (T.D.B., D.T.), University of Washington, Seattle; Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN; Hope Center for Neurological Disorders (C.C.), Washington University, St Louis, MO; Department of Medical and Molecular Genetics (K.F., T.M.F.), Indiana University; Department of Neurology (M.F.), Indiana University Center for Alzheimer's Disease and Related Disorders, Indianapolis; Department of Neuroscience (A.M.G., S.B.), Mount Sinai School of Medicine, New York, NY; Department of Neurology (N.R.G.-R.), Mayo Clinic, Jacksonville, FL; School of Medicine (M.M., R.M.), Mother and Teacher Pontifical Catholic University, Santiago, Dominican Republic; Department of Medicine (R.L.) and Department of Epidemiology, Mailman School of Public Health (R.O., N.S.), Columbia University, New York; Division of Epidemiology (R.O.), New York State Psychiatric Institute, New York; Department of Neurology and Neurotherapeutics (R.R.), The University of Texas Southwestern Medical Center, Dallas; Department of Health Sciences Research (D.J.S.), Mayo Clinic, Rochester, MN; and Department of Psychiatry, Neurology and Epidemiology (R.A.S.), University of Pittsburgh, PA. rpm2@cumc.columbia.edu.
Publikováno v:
Neurology [Neurology] 2017 Mar 21; Vol. 88 (12), pp. 1180-1186. Date of Electronic Publication: 2017 Feb 17.
Autor:
Mez J; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA. Electronic address: jessemez@bu.edu., Chung J; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Jun G; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA; Department of Ophthalmology, Boston University School of Medicine, Boston, MA, USA., Kriegel J; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA., Bourlas AP; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA., Sherva R; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Logue MW; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Barnes LL; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Bennett DA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Buxbaum JD; Departments of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA; Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA., Byrd GS; Department of Biology, North Carolina A & T State University, Greensboro, NC, USA., Crane PK; Department of Medicine, University of Washington, Seattle, WA, USA., Ertekin-Taner N; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Evans D; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Fallin MD; Department of Mental Health, Johns Hopkins School of Public Health, Baltimore, MD, USA; Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD, USA; Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD, USA., Foroud T; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA., Goate A; Departments of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA; Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA., Graff-Radford NR; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Hall KS; Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA., Kamboh MI; Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA., Kukull WA; Department of Epidemiology, University of Washington, Seattle, WA, USA., Larson EB; Group Health, Group Health Research Institute, Seattle, WA, USA., Manly JJ; Department of Neurology and the Taub Institute, Columbia University, New York, NY, USA., Haines JL; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA., Mayeux R; Department of Neurology and the Taub Institute, Columbia University, New York, NY, USA., Pericak-Vance MA; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA., Schellenberg GD; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lunetta KL; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Farrer LA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA; Department of Ophthalmology, Boston University School of Medicine, Boston, MA, USA; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
Publikováno v:
Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2017 Feb; Vol. 13 (2), pp. 119-129. Date of Electronic Publication: 2016 Oct 20.