Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Keizo Umegaki"'
Autor:
Keizo Umegaki, Mika Yoshimura, Hiroyuki Takenaka, Pang Daohua, Takatoshi Esashi, Kazumasa Shinozuka, Ken Watarai
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 27:277-282
SUMMARY 1. We examined the effects of Ginkgo biloba extract (GBE) on the development of hypertension, platelet activation and renal dysfunction in deoxycorticosterone acetate (DOCA)- salt hypertensive rats. Both DOCA-salt hypertensive rats and normot
Publikováno v:
Journal of Pharmacobio-Dynamics. 15:49-57
Platelets from stroke-prone spontaneously hypertensive rats (SHRSP) show severe hypofunctions accompanied by defective protein (P47) phosphorylation. To examine the mechanism of platelet hypofunctions, phospholipid metabolism in SHRSP was compared wi
Autor:
Keizo Umegaki, Tomio Ichikawa
Publikováno v:
Journal of nutritional science and vitaminology. 39(5)
Changes in platelet aggregability patterns and lipid peroxide levels and their relationship were examined in DOCA-salt hypertensive rats during the development of hypertension. In addition, the effect of vitamin E treatment on those changes was also
Publikováno v:
Thrombosis and haemostasis. 65(4)
SummaryEffects of vitamin E on platelet function and serum lipid peroxide levels were investigated in DOCA-salt hypertensive rats. In the hypertensive rats, ADP- and collagen-induced platelet aggregation in whole blood were markedly attenuated and ac
Publikováno v:
Journal of Hypertension. 7:13-19
In washed platelets both from DOCA-salt and renal hypertensive rats, there was a marked decrease in thrombin-induced aggregation and secretion responses compared with those of respective controls. Concomitantly, the platelets showed attenuated malond
Publikováno v:
Thrombosis and Haemostasis. 54:764-767
SummaryStroke was induced in stroke-prone spontaneously hypertensive rats (SHRSP) by NaCl loading. They were killed at 3 weeks and cerebral lesion was confirmed by autopsy. About 2/3 of them had strokes. Platelet count and thrombin-induced aggregatio
Publikováno v:
Stroke. 15:70-75
The aggregation properties of washed SHRSP platelets were investigated in comparison with normotensive WKY platelets at prehypertensive (4 weeks), early hypertensive (11 weeks) and late hypertensive (17 weeks) ages in the absence of plasma factors. T
Publikováno v:
Journal of Pharmacological Methods. 10:31-44
The basic characteristics of washed rat platelets in aggregation and biochemical responses to thrombin and collagen were investigated. Maximum aggregation response to thrombin and collagen was observed in the presence of 1–3 mM extracellular CA2+.
Publikováno v:
Hypertension. 14:304-315
The mechanism of platelet dysfunctions in stroke-prone spontaneously hypertensive rats (SHRSP) was investigated. Platelet aggregation was inversely correlated with blood pressure or heart weight/body weight ratios in various strains of spontaneously
Publikováno v:
FEBS Letters. (1):139-144
Aggregation and secretion of washed platelets from stroke-prone spontaneously hypertensive rats (SHRSP) were greatly reduced by the development of the hypertension compared with those of platelets from agematched normotensive Wistar-Kyoto rats (WKY).