Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Thirumalaisamy P. Velavan"'
Autor:
Moses Ikegbunam, Johnson A. Ojo, Kossiwa Kokou, Ugonna Morikwe, Chukwuemeka Nworu, Chibuzo Uba, Charles Esimone, Thirumalaisamy P. Velavan, Olusola Ojurongbe
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-6 (2021)
Abstract Background The occurrence of artemisinin resistance (ART)-associated polymorphism of Plasmodium falciparum K13-propeller (pfk13) gene before and after the introduction of artemisinin-based combination therapy (ACT) in two regions of Nigeria
Externí odkaz:
https://doaj.org/article/8a7192ce401c432e9b03a3673e625fba
Autor:
Louis Regis Dossou-Yovo, Francine Ntoumi, Felix Koukouikila-Koussounda, Jeannhey Christevy Vouvoungui, Ayodele Adedoja, David Nderu, Thirumalaisamy P. Velavan, Arsène Lenga
Publikováno v:
Malaria Journal, Vol 19, Iss 1, Pp 1-6 (2020)
Abstract Background Malaria in pregnancy is associated with considerable morbidity and mortality. Regular surveillance of artemisinin-based combination therapy tolerance, or molecular makers of resistance, is vital for effective malaria treatment, co
Externí odkaz:
https://doaj.org/article/a4ac3c2a27fb40daa4766a8f8ab04d66
Autor:
Moses N. Ikegbunam, Charles N. Nkonganyi, Bolaji N. Thomas, Charles O. Esimone, Thirumalaisamy P. Velavan, Olusola Ojurongbe
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-7 (2019)
Abstract Background A reversal of chloroquine (CQ) resistance following a period of withdrawal has raised the possibility of its re-introduction. This study evaluated the current prevalence of Pfcrt and Pfmdr1 alleles in Plasmodium falciparum isolate
Externí odkaz:
https://doaj.org/article/1b30c501f62749fe90b28ebd4cd6e91b
Autor:
Felix Koukouikila-Koussounda, Sankarganesh Jeyaraj, Christian N. Nguetse, Charles Nchotebah Nkonganyi, Kossiwa Clarisse Kokou, Mandingha K. Etoka-Beka, Francine Ntoumi, Thirumalaisamy P. Velavan
Publikováno v:
Malaria Journal, Vol 16, Iss 1, Pp 1-7 (2017)
Abstract Background Resistance to anti-malarial drugs hinders efforts on malaria elimination and eradication. Following the global spread of chloroquine-resistant parasites, the Republic of Congo adopted artemisinin-based combination therapy (ACT) in
Externí odkaz:
https://doaj.org/article/35b9427bb75349c4a5f957df450737ed
Autor:
Natasha Purington, Emily R. Ebel, Bikash Shakya, Marilou Tétard, Christian N. Nguetse, Elizabeth S. Egan, Thirumalaisamy P. Velavan, Peter G. Kremsner
Publikováno v:
Proceedings of the National Academy of Sciences. 117:9074-9081
Malaria caused by the apicomplexan parasite Plasmodium falciparum has served as a strong evolutionary force throughout human history, selecting for red blood cell polymorphisms that confer innate protection against severe disease. Recently, gain-of-f
Autor:
Volker M. Lauschke, Jeannot Fréjus Zinsou, Sanjeev Krishna, Peter G. Kremsner, Leyre Pernaute-Lau, Yitian Zhou, Ayola A. Adegnika, Thirumalaisamy P. Velavan, José Pedro Gil
Publikováno v:
Antimicrob Agents Chemother
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Antimicrobial Agents and Chemotherapy
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Antimicrobial Agents and Chemotherapy
Funding Information: T.P.V., P.G.K., and A.A.A. acknowledge financial support from the German Center for Infection Research (DZIF), Clinical Research Group, Lambarene, and a German Science Foundation grant (DFG Ku 775/17-1) for the German African Coo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6623383509ef5aec1b4cd83f4386825
https://hdl.handle.net/10362/131181
https://hdl.handle.net/10362/131181
Autor:
Francine Ntoumi, Christevy Vouvoungui, David Nderu, Felix Koukouikila-Koussounda, Simon Marie Peko, Simon Charles Kobawila, Thirumalaisamy P. Velavan
Publikováno v:
International Journal of Infectious Diseases, Vol 85, Iss, Pp 49-53 (2019)
Background: Cytochrome P450 (CYP) enzymes are essential in the metabolism of most drugs used today. Single nucleotide polymorphism(s) occurring in CYP genes can adversely affect drug pharmacokinetics, efficacy, and safety. Individuals carrying the CY
Autor:
Srinivas Reddy Pallerla, Bolaji N. Thomas, David Nderu, Thirumalaisamy P. Velavan, Sunday A. Adebusuyi, Abimbola O. Amoo, Kaossarath A. Fagbemi, Samuel A. Adedokun, Olusola Ojurongbe
Publikováno v:
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 85
Intermittent preventive treatment in pregnancy with sulphadoxine-pyrimethamine (IPTp-SP) is one of the main strategies for protecting pregnant women, fetus, and their new-born against adverse effects of P. falciparum infection. The development of the
Autor:
Christian N, Nguetse, Natasha, Purington, Emily R, Ebel, Bikash, Shakya, Marilou, Tetard, Peter G, Kremsner, Thirumalaisamy P, Velavan, Elizabeth S, Egan
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The clinical presentation of Plasmodium falciparum malaria as severe versus uncomplicated is influenced by host genetic factors. Recently, a gain-of-function mutation in the mechanosensitive ion channel PIEZO1 was shown to protect mice a
Autor:
Arsene Lenga, Francine Ntoumi, Ayodele Adedoja, Felix Koukouikila-Koussounda, Louis Regis Dossou-Yovo, David Nderu, Jeannhey Christevy Vouvoungui, Thirumalaisamy P. Velavan
Publikováno v:
Malaria Journal, Vol 19, Iss 1, Pp 1-6 (2020)
Malaria Journal
Malaria Journal
Background Malaria in pregnancy is associated with considerable morbidity and mortality. Regular surveillance of artemisinin-based combination therapy tolerance, or molecular makers of resistance, is vital for effective malaria treatment, control and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ac7de8a9c7eaf15b8feba5c2b4cdce
https://doi.org/10.21203/rs.2.17894/v2
https://doi.org/10.21203/rs.2.17894/v2