Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Reinaldo N. Takahashi"'
Autor:
Cristina A J, Stern, Thiago R, da Silva, Ana M, Raymundi, Camila P, de Souza, Vinicius A, Hiroaki-Sato, Luiza, Kato, Francisco S, Guimarães, Roberto, Andreatini, Reinaldo N, Takahashi, Leandro J, Bertoglio
Publikováno v:
Neuropharmacology. 125
Pharmacological interventions able to modulate a fear memory while it is consolidated could have therapeutic value in tempering those maladaptively overconsolidated. Animal and human studies have shown the intensity of unconditioned stimulus delivere
Autor:
Rafael Mariano de Bitencourt, Juliana A.V. Kroon, Rimenez R. Souza, Fabricio Hoffmann Martins Do Monte, Reinaldo N. Takahashi
Publikováno v:
Behavioural Brain Research. 250:23-27
Previous studies have implicated cannabinoids in extinction of conditioned fear. We have recently showed that intraventricular infusion of the phytocannabinoid cannabidiol (CBD) facilitates fear extinction, but the brain regions underlying this effec
Autor:
Carla I. Tasca, Carina Akemi Nakamura, Tetsadê C. B. Piermartiri, Reinaldo N. Takahashi, Fabrício Luiz Assini
Publikováno v:
Behavioural Pharmacology. 23:292-301
The aim of this study was to characterize the interaction of adenosine A1-receptor and cannabinoid CB1-receptor antagonists in the water maze and object-location tasks, and to evaluate the participation of glutamatergic neurotransmission in the hippo
Publikováno v:
Psychopharmacology. 188:641-649
Rationale Previous studies demonstrated that pharmacological blockade of CB1 cannabinoid receptors decreases the extinction of conditioned fear and spatial memory in rodents. However, the effects of CB1 cannabinoid receptor activation in this respons
Publikováno v:
Neuroscience Letters. 380:270-275
Δ9-THC and synthetic cannabinoids produce memory impairment in humans as well as in laboratory animals. The high concentration of cannabinoid CB1 receptors and the presence of endocannabinoids in the hippocampus suggest that a cannabinoid neurochemi
Publikováno v:
Neuroscience letters. 470(1)
Evidence are that inhibition of cyclooxygenase 2 (COX-2) enhances endocannabinoid signaling, indicating a crosstalk between these two eicosanoid pathways. Aspirin, a non-selective COX inhibitor, acetylates COX-2 with generation of a lipoxygenase (LOX
Publikováno v:
Psychopharmacology. 194(2)
Our previous findings have shown rapid cross-tolerance between ethanol and Delta(9)-tetrahydrocannabinol and that intraperitoneal (i.p.) injection of cannabinoid receptor type 1 (CB1R) antagonist SR141716 (SR) does not interfere with tolerance to eit
WIN 55212-2 impairs contextual fear conditioning through the activation of CB1 cannabinoid receptors
Publikováno v:
Neuroscience letters. 397(1-2)
The memory deficits induced by cannabinoid agonists have been found in several behavioral paradigms. Nevertheless, there is evidence that not all types of memory are impaired after cannabinoid administration. The aim of this study was to investigate