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pro vyhledávání: '"Carmen Garnacho"'
Autor:
Carmen Garnacho
Publikováno v:
Scopus-Elsevier
Over the last half century, the delivery of pharmacologically active substances, such as synthetic drugs, natural compounds, gene material and many other pharmaceutical products, has been widely studied. Understanding the interactions of drug carrier
A Comparative Study on the Alterations of Endocytic Pathways in Multiple Lysosomal Storage Disorders
Publikováno v:
Molecular Pharmaceutics. 13:357-368
Many cellular activities and pharmaceutical interventions involve endocytosis and delivery to lysosomes for processing. Hence, lysosomal processing defects can cause cell and tissue damage, as in lysosomal storage diseases (LSDs) characterized by lys
Publikováno v:
Molecular Pharmaceutics. 12:1366-1376
Pharmaceutical intervention often requires therapeutics and/or their carriers to enter cells via endocytosis. Therefore, endocytic aberrancies resulting from disease represent a key, yet often overlooked, parameter in designing therapeutic strategies
Publikováno v:
Molecular Pharmaceutics
Drugs often use endocytosis to achieve intracellular delivery, either by passive uptake from the extracellular fluid or by active targeting of cell surface features such as endocytic receptors. An example is enzyme replacement therapy, a clinically p