Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Youyi Zhang"'
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Frontiers in Physiology
Frontiers in Physiology
Inflammation promotes the development of heart failure (HF). The inflammasome is a multimeric protein complex that plays an essential role in the innate immune response by triggering the cleavage and activation of the proinflammatory cytokines interl
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 44:648-655
Metformin is a well-known AMP-activated protein kinase (AMPK) activator, and it has been shown to inhibit organ fibrosis. Whether AMPKα2 mediates metformin protection against renal fibrosis remains unknown. Here, we aimed to investigate the role of
Autor:
Yao Song, Xiangbo An, Qiang Shen, Youyi Zhang, Jimin Wu, Hao Li, Jing-Jing Wang, Yunong Wu, Jing Shen, Jianshu Zhang, Han Xiao
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 43:1029-1037
Senescent hearts exhibit defective responses to β-adrenergic receptor (β-AR) over-activation upon stress, leading to more severe pathological cardiac remodelling. However, the underlying mechanisms remain unclear. Here, we investigated the role of
Autor:
Haijing Wang, Xiangbo An, Guan Yang, Youyi Zhang, Xiao Yang, Song Zuo, Yao Song, Linling Li, Zhenhua Li, Jing Wang, Xuan Cheng, Lantao Liu, Nian Liu
Publikováno v:
Cardiovascular Research. 111:56-65
Aims The H19 lncRNA, a highly abundant and conserved imprinted gene, has been implicated in many essential biological processes and diseases. However, the function of H19 in the heart remains unknown. In this study, we investigated the function and u
Publikováno v:
Cardiovascular Research. 110:258-267
Aims Overexpression of either member of the miR-199 family, miR-199a-5p or miR-199b-5p (hereinafter referred to as miR-199a or miR-199b), promotes pathological cardiac hypertrophy, but little is known about the role of endogenous miR-199 in cardiac d
Autor:
Xin You, Yang Li, Lei Zhou, Wen-Jing Wang, Yong Zhao, Chun Fan, Xiao-Li Tian, Xin He, Jie Dong, Fan Yang, Qiguang Wang, Juxian Yang, Ming Zhao, Jing-Wei Xiong, Youyi Zhang, Ting Zhao, Chong Wu, Gu-Yan Zheng, Huiqing Cao, Ying Li, Xiaonan Han, Fang-Yuan Hu, Xian-Min Meng, Zai Chang, Xianyang Zhu, Chunyan Cheng
Publikováno v:
Cardiovascular Research. 103:228-237
Aims Cardiac structural genes have been implicated as causative factors for congenital heart diseases (CHDs). NEXN is an F-actin binding protein and previously identified as a disease gene causing cardiomyopathies. Whether NEXN contributes to CHDs ae
Autor:
Weili Shen, Youyi Zhang, Maoqing Ye, Wei-Qing Han, Xiao-Hui Chen, Dong-Rui Chen, Pingjin Gao, Xiangbo An
Publikováno v:
Frontiers in Physiology
Chronic exercise training is known to protect the vasculature; however, the underlying mechanisms remain obscure. The present study hypothesized that exercise may improve aortic endothelial and mitochondrial function through an adenosine monophosphat
Publikováno v:
Cardiovascular Research. 114:S88-S89
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 41:58-66
1. Chronic injection with the β-adrenoceptor (β-AR) agonist isoproterenol (ISO) has been commonly used as an animal model of β-AR-induced cardiac remodelling and heart failure. This ISO-treated model usually exhibits significantly decreased consci
Autor:
Zijian Li, Chao Chen, Zhizhen Lu, Youyi Zhang, Yan Li, Hui Zhang, Wenqiang Liao, Yao Song, Xiaowei Ma
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 301:H1941-H1951
Li Y, Zhang H, Liao W, Song Y, Ma X, Chen C, Lu Z, Li Z, Zhang Y. α1-Adrenergic receptor (α1-AR) is a crucial mediator of cardiac hypertrophy. Although numerous intracellular pathways have been implicated in α1-AR-induced hypertrophy, its precise