Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sander Barnhoorn"'
Autor:
Annelieke S. de Wit, Sander Barnhoorn, Mirjam M.C. Wamelink, Renata M. C. Brandt, César Payán-Gómez, Akos Gyenis, Jan H.J. Hoeijmakers, Wilbert P. Vermeij, Pier G. Mastroberardino, André B.P. van Kuilenburg, Donatella Caruso, Sara Sepe, Matteo Audano, René Leen, Roel C. Janssens, Nico Mitro, Cíntia R. Bombardieri, Chiara Milanese, Silvia Pedretti
Publikováno v:
Nature Communications, 10:4887. Nature Publishing Group
Nature Communications
Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature communications, 10(1):4887. Nature Publishing Group
Nature Communications, 10(1):4887. Nature Publishing Group
Milanese, C, Bombardieri, C N R, Sepe, S, Barnhoorn, S, Payán-Goméz, C S, Caruso, D, Audano, M, Pedretti, S, Vermeij, W P, Brandt, R M C, Gyenis, A, Wamelink, M M, de Wit, A S, Janssens, R C, Leen, R, van Kuilenburg, A B P, Mitro, N, Hoeijmakers, J H J & Mastroberardino, P G 2019, ' DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering ', Nature Communications, vol. 10, no. 1, 4887 . https://doi.org/10.1038/s41467-019-12640-5
Nature Communications
Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature communications, 10(1):4887. Nature Publishing Group
Nature Communications, 10(1):4887. Nature Publishing Group
Milanese, C, Bombardieri, C N R, Sepe, S, Barnhoorn, S, Payán-Goméz, C S, Caruso, D, Audano, M, Pedretti, S, Vermeij, W P, Brandt, R M C, Gyenis, A, Wamelink, M M, de Wit, A S, Janssens, R C, Leen, R, van Kuilenburg, A B P, Mitro, N, Hoeijmakers, J H J & Mastroberardino, P G 2019, ' DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering ', Nature Communications, vol. 10, no. 1, 4887 . https://doi.org/10.1038/s41467-019-12640-5
Accumulation of DNA lesions causing transcription stress is associated with natural and accelerated aging and culminates with profound metabolic alterations. Our understanding of the mechanisms governing metabolic redesign upon genomic instability, h
Autor:
Akos Gyenis, Raoul Kuiper, Sameh A. Youssef, M.E.T. Dollé, Renata M. C. Brandt, C. T. M. Van Oostrom, Wilbert P. Vermeij, Bhawani Nagarajah, B.C.J. van der Eerden, H. van Steeg, Jan Vijg, Dick Jaarsma, A. de Bruin, Cíntia R. Bombardieri, Anton J.M. Roks, Sandra Imholz, Sander Barnhoorn, Joris Pothof, H. Wu, S. M. Botter, Erwin Reiling, César Payán-Gómez, Jan H.J. Hoeijmakers, Jeroen L. A. Pennings
Publikováno v:
Nature, 537(7620), 427-431. Nature Publishing Group
Nature
Nature, 537(7620), 427
Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario
Nature
Nature, 537(7620), 427
Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario
Mice deficient in the DNA excision-repair gene Ercc1 (Ercc1?/-) show numerous accelerated ageing features that limit their lifespan to 4-6 months. They also exhibit a 'survival response', which suppresses growth and enhances cellular maintenance. Suc
Autor:
George A. Garinis, Veerle Darras, Robin P. Peeters, Hans van Toor, Ramona van Heerebeek, Martijn E.T. Dollé, Anita Boelen, Sander Barnhoorn, Joan Kwakkel, Renata M. C. Brandt, John J. Kopchick, Joost P.M. Melis, W. Edward Visser, Ellen Kaptein, Edward O. List, Theo J. Visser, Marco Medici, Ingrid van der Pluijm, Wilbert P. Vermeij, Alexandre Ottaviani, Gijsbertus T. J. van der Horst, Monique C. de Waard, Jan H.J. Hoeijmakers, Ronald R. de Krijger, Willy van Ham, Cíntia R. Bombardieri, Chantal Zevenbergen
Publikováno v:
PLoS ONE, 11(3). Public Library of Science
PLoS ONE, 11(3):e0149941. Public Library of Science
PLoS ONE
PLoS One (print), 11(3). Public Library of Science
PLoS ONE, Vol 11, Iss 3, p e0149941 (2016)
Visser, W E, Bombardieri, C R, Zevenbergen, C, Barnhoorn, S, Ottaviani, A, van der Pluijm, I, Brandt, R, Kaptein, E, van Heerebeek, R, van Toor, H, Garinis, G A, Peeters, R P, Medici, M, van Ham, W, Vermeij, W P, de Waard, M C, de Krijger, R R, Boelen, A, Kwakkel, J, Kopchick, J J, List, E O, Melis, J P M, Darras, V M, Dolle, M E T, van der Horst, G T J, Hoeijmakers, J H J & Visser, T J 2016, ' Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging ', PLoS ONE, vol. 11, no. 3, e0149941 . https://doi.org/10.1371/journal.pone.0149941
PLoS ONE [E], 11(3). Public Library of Science
PLoS ONE, 11(3):e0149941. Public Library of Science
PLoS ONE
PLoS One (print), 11(3). Public Library of Science
PLoS ONE, Vol 11, Iss 3, p e0149941 (2016)
Visser, W E, Bombardieri, C R, Zevenbergen, C, Barnhoorn, S, Ottaviani, A, van der Pluijm, I, Brandt, R, Kaptein, E, van Heerebeek, R, van Toor, H, Garinis, G A, Peeters, R P, Medici, M, van Ham, W, Vermeij, W P, de Waard, M C, de Krijger, R R, Boelen, A, Kwakkel, J, Kopchick, J J, List, E O, Melis, J P M, Darras, V M, Dolle, M E T, van der Horst, G T J, Hoeijmakers, J H J & Visser, T J 2016, ' Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging ', PLoS ONE, vol. 11, no. 3, e0149941 . https://doi.org/10.1371/journal.pone.0149941
PLoS ONE [E], 11(3). Public Library of Science
DNA damage contributes to the process of aging, as underscored by premature aging syndromes caused by defective DNA repair. Thyroid state changes during aging, but underlying mechanisms remain elusive. Since thyroid hormone (TH) is a key regulator of
Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency
Autor:
Gijsbertus T. J. van der Horst, Ingrid van der Pluijm, Hervé Menoni, Wilbert P. Vermeij, Renata M. C. Brandt, Jan H.J. Hoeijmakers, Sander Barnhoorn, Monique C. de Waard, S.M. Botter, Dick Jaarsma, Priscilla K. Cooper, Altaf H. Sarker, Maria Tresini, Nicolaas G. J. Jaspers, Michael Weymaere, Lieneke M. Uittenboogaard
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004686 (2014)
PLoS Genetics
PLoS genetics, vol 10, iss 10
Barnhoorn, S; Uittenboogaard, LM; Jaarsma, D; Vermeij, WP; Tresini, M; Weymaere, M; et al.(2014). Cell-Autonomous Progeroid Changes in Conditional Mouse Models for Repair Endonuclease XPG Deficiency. PLoS Genetics, 10(10). doi: 10.1371/journal.pgen.1004686. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/5qz7h7b6
PLoS Genetics, 10(10):e1004686. Public Library of Science
Barnhoorn, S, Uittenboogaard, L M, Jaarsma, D, Vermeij, W P, Tresini, M, Weymaere, M, Menoni, H, Brandt, R M C, de Waard, M C, Botter, S M, Sarker, A H, Jaspers, N G J, van der Horst, G T J, Cooper, P K, Hoeijmakers, J H J & van der Pluijm, I 2014, ' Cell-Autonomous Progeroid Changes in Conditional Mouse Models for Repair Endonuclease XPG Deficiency ', PLoS Genetics, vol. 10, no. 10, e1004686 . https://doi.org/10.1371/journal.pgen.1004686
PLoS Genetics (print), 10(10). Public Library of Science
PLoS Genetics
PLoS genetics, vol 10, iss 10
Barnhoorn, S; Uittenboogaard, LM; Jaarsma, D; Vermeij, WP; Tresini, M; Weymaere, M; et al.(2014). Cell-Autonomous Progeroid Changes in Conditional Mouse Models for Repair Endonuclease XPG Deficiency. PLoS Genetics, 10(10). doi: 10.1371/journal.pgen.1004686. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/5qz7h7b6
PLoS Genetics, 10(10):e1004686. Public Library of Science
Barnhoorn, S, Uittenboogaard, L M, Jaarsma, D, Vermeij, W P, Tresini, M, Weymaere, M, Menoni, H, Brandt, R M C, de Waard, M C, Botter, S M, Sarker, A H, Jaspers, N G J, van der Horst, G T J, Cooper, P K, Hoeijmakers, J H J & van der Pluijm, I 2014, ' Cell-Autonomous Progeroid Changes in Conditional Mouse Models for Repair Endonuclease XPG Deficiency ', PLoS Genetics, vol. 10, no. 10, e1004686 . https://doi.org/10.1371/journal.pgen.1004686
PLoS Genetics (print), 10(10). Public Library of Science
As part of the Nucleotide Excision Repair (NER) process, the endonuclease XPG is involved in repair of helix-distorting DNA lesions, but the protein has also been implicated in several other DNA repair systems, complicating genotype-phenotype relatio