Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kritton Shay-Winkler"'
Autor:
Jeffrey Robbins, Katherine E. Yutzey, James Gulick, Yang Yu, Na Xu, Hanna Osinska, Kritton Shay-Winkler, Patrick M. McLendon
Publikováno v:
Circ Res
Rationale: Compromised protein quality control can result in proteotoxic intracellular protein aggregates in the heart, leading to cardiac disease and heart failure. Defining the participants and understanding the underlying mechanisms of cardiac pro
Autor:
Keri Anne Drake, Prasad Devarajan, Brian J. Siroky, Kritton Shay-Winkler, Priyanka Parameswaran, LaTawnya Pleasant, Qing Ma, Jeffrey Robbins, Mahima Devarajan
Publikováno v:
American Journal of Physiology-Renal Physiology. 313:F699-F705
The early events that signal renal dysfunction in presymptomatic heart failure are unclear. We tested the hypothesis that functional and mechanistic changes occur in the kidney that precede the development of symptomatic heart failure. We employed a
Autor:
Shenuarin Bhuiyan, Iñigo Valiente-Alandi, Jeffrey Robbins, Burns C. Blaxall, Jeffery D. Molkentin, James Gulick, Qinghang Meng, Bidur Bhandary, Hanna Osinska, Kritton Shay-Winkler, Jeanne James
Publikováno v:
Circulation research. 123(12)
Rationale: Hypertrophic cardiomyopathy occurs with a frequency of about 1 in 500 people. Approximately 30% of those affected carry mutations within the gene encoding cMyBP-C (cardiac myosin binding protein C). Cardiac stress, as well as cMyBP-C mutat
Autor:
Bidur Bhandary, Jeffrey Robbins, Hanna Osinska, Qing Hang Meng, Na Xu, Kritton Shay-Winkler, James Gulick
Publikováno v:
Circulation Research. 123
Introduction: Impairment of protein quality control leads to the accumulation of intracellular misfolded protein aggregates, contributing to cardiac disease and heart failure. Essential protein quality control pathways, including proteasomal degradat
Autor:
James Gulick, Jeffrey Robbins, Jeanne James, James W. McNamara, Md. Shenuarin Bhuiyan, Qinghang Meng, Bidur Bhandary, Kritton Shay-Winkler, Sakthivel Sadayappan, Hanna Osinska
Publikováno v:
Circulation Research. 123
Background: Mutations in cardiac myosin binding protein C ( MYBPC3 ) account for more than one third of identified hypertrophic cardiomyopathy (HCM). Data from both human patients and mouse models suggest that cardiac fibrosis preceeds hypertrophy an
Autor:
Bidur Bhandary, Qinghang Meng, James Gulick, Hanna Osinska, Kritton Shay-Winkler, Jeffrey Robbins
Publikováno v:
Circulation Research. 121
Introduction: Transforming Growth Factor beta (TGFβ) is an important cytokine in mediating cardiac fibrosis. Cardiomyocyte-specific expression of a mutant αB-crystallin (CryAB R120G ) that is responsible for human Desmin Related Myopathy results in
Autor:
Qinghang Meng, Jeffrey Robbins, Monte S. Willis, Hanna Osinska, Kritton Shay-Winkler, Bidur Bhandary, Na Xu
Publikováno v:
Circulation Research. 121
Background: Hypertrophic cardiomyopathy is considered one of the most common genetic heart disorders, occurring with a frequency of about 1 in 200, with approximately 30% of those affected showing mutations within the cardiac myosin-binding protein C
Autor:
Jeffrey Robbins, James Gulick, Qinghang Meng, Shenuarin Bhuiyan, Bidur Bhandary, Hanna Osinska, Kritton Shay-Winkler
Publikováno v:
Circulation Research. 119
Introduction: Transforming Growth Factor Beta (TGFβ) is an important cytokine in mediating the fibrogenic response and, in particular, cardiac fibrosis. Extensive fibrosis accompanies the cardiac remodeling that occurs during development of the prot