Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Carl W. White"'
Autor:
Daniel M. Hinds, Heidi J. Nick, Tessa M. Vallin, Leslie A. Bloomquist, Sarah Christeson, Preston E. Bratcher, Emily H. Cooper, John T. Brinton, Angela Bosco-Lauth, Carl W. White
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 323:L525-L535
E-cigarette vaping is a major aspect of nicotine consumption, especially for children and young adults. Although it is branded as a safer alternative to cigarette smoking, murine and rat models of subacute and chronic e-cigarette vaping exposure have
Publikováno v:
Antioxidants & Redox Signaling. 10:277-286
Lipoic acid (LA) and its reduced product dihydrolipoic acid (DHLA) are potent antioxidants with capacity to scavenge reactive oxygen species (ROS) and recycle endogenous antioxidants. LA may increase cellular glutathione (GSH), an antioxidant lacking
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 292:L1345-L1351
Respiratory distress syndrome (RDS) secondary to preterm birth and surfactant deficiency is characterized by severe hypoxemia, lung injury, and impaired production of nitric oxide (NO) and vascular endothelial growth factor (VEGF). Since hypoxia-indu
Autor:
Louis J. Dell’Italia, Stephen F. Doran, Carl W. White, Ahmed Zaky, Wayne E. Bradley, Sadis Matalon, Aftab Ahmad, Ahmed Lazrak, Iram Zafar, Shama Ahmad
Publikováno v:
Physiological Reports
Victims of chlorine (Cl2) inhalation that die demonstrate significant cardiac pathology. However, a gap exists in the understanding of Cl2-induced cardiac dysfunction. This study was performed to characterize cardiac dysfunction occurring after Cl2 e
Autor:
Corrie B. Allen, Suzette R. Riddle, Carl W. White, Barbara K. Schneider, Raymond C. Rancourt, Shama Ahmad, Mihalis I. Panayiotidis
Publikováno v:
Antioxidants & Redox Signaling. 6:129-136
The effect of hyperoxia on levels of DNA damage and global DNA methylation was examined in lung epithelial-like A549 cells. DNA damage was assessed by the single-cell gel electrophoresis (comet assay) and DNA methylation status by the cytosine extens
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 283:L573-L584
Increased glucose utilization and hexokinase (HK)-II expression are adaptive features of lung cells exposed to hypoxia or hyperoxia. HK-II is the most regulated isoform of HK. Whether its overexpression could be protective against oxidative stress wa
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 281:L1021-L1027
Exposure of cultured cells to changing gaseous environments is used as a model for understanding both the immediate and long-term effects of such exposures on lung cells in vivo. We conducted experiments with polystyrene tissue culture flasks and pla
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 280:L779-L791
Glutamine is an important mitochondrial substrate implicated in the protection of cells from oxidant injury, but the mechanisms of its action are incompletely understood. Human pulmonary epithelial-like (A549) cells were exposed to 95% O2for 4 days i
Autor:
Shama Ahmad, B. Kelly Schneider, Mari Malkki, Corrie B. Allen, Samir S. Deeb, Carl W. White, Aftab Ahmad, Suzette R. Riddle
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 278:L407-L416
During adaptation to hypoxic and hyperoxic conditions, the genes involved in glucose metabolism are upregulated. To probe involvement of the transcription factor hypoxia-induced factor-1 (HIF-1) in hexokinase (HK) II expression in human pulmonary cel
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 276:L64-L74
We investigated the effects of gestational age and oxygen exposure on superoxide dismutase (SOD) activities in distal fetal lung tissue in primate models of bronchopulmonary dysplasia. During the final third of fetal life, lung coppper-zinc SOD (Cu,Z