Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Si‐Qing Zhang"'
Autor:
Gengyun Wen, Benjamin G. Neel, Toshiyuki Araki, Si Qing Zhang, Ruediger Klein, Liliana Minichiello, William G. Tsiaras
Publikováno v:
Zhang, S Q, Tsiaras, W G, Araki, T, Wen, G, Minichiello, L, Klein, R & Neel, B G 2002, ' Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2 ', Molecular and Cellular Biology, vol. 22, no. 12, pp. 4062-72 . https://doi.org/10.1128/MCB.22.12.4062-4072.2002
Receptor tyrosine kinases (RTKs) play distinct roles in multiple biological systems. Many RTKs transmit similar signals, raising questions about how specificity is achieved. One potential mechanism for RTK specificity is control of the magnitude and
Publikováno v:
Immunity. 12(3):301-311
The adapter protein RIP plays a crucial role in NF-kappaB activation by TNF. Here we show that triggering of the p55 TNF receptor induces binding of RIP to NEMO (IKKgamma), a component of the I-kappa-B-kinase (IKK) "signalosome" complex, as well as r
Autor:
Wentian Yang, Jincai Luo, Benjamin G. Neel, Si Qing Zhang, Burkhart Schraven, Gengyun Wen, Trever G. Bivona, Julie A. Thompson, Toshiyuki Araki, Mark R. Philips, Maria I. Kontaridis
Publikováno v:
Molecular cell. 13(3)
The protein-tyrosine phosphatase Shp2 plays an essential role in growth factor and integrin signaling, and Shp2 mutations cause developmental defects and/or malignancy. Previous work has placed Shp2 upstream of Ras. However, the mechanism of Shp2 act